2F83,2F83,2F83,2F83


Conserved Protein Domain Family
APPLE

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smart00223: APPLE 
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APPLE domain
Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.
Statistics
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PSSM-Id: 128519
View PSSM: smart00223
Aligned: 19 rows
Threshold Bit Score: 64.3245
Threshold Setting Gi: 6225677
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2F83_A     20 CVTQlLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPS----E----DptrwfT-----CVLKDSVTETL 86  human
EDL35544  336 CHSKiYSGVDFEGEELNVTFVQGADVCQETCTKTIRCQFFIYSLLPQD----C----Kee-gcK-----CSLRLSTDGSP 401 house mouse
BAF85313  111 CHRDiYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFH----KaeyrN-----N-----CLLKYSPGGTP 176 human
AAC24506  237 CHSSfYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQAS----C----Neg-kgK-----CYLKLSSNGSP 302 human
AAA51985  110 CNKDiYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPslehR----N-----I-----CLLKHTQTGTP 175 human
CAA65843   61 CAQQ-FPNVDFNGDDIQTIYGIQPGECCTRCSETAGCKAYTFVNSNPG----Q----P-----A-----CYLK---SGTG 118 Phytophthora paras...
CAA65843  197 CSKQ-LTDKDYYGNDIKTVYVSLPSLCCDACASTAGCKAYTYINNNPG----Q----P-----V-----CYLK---SAAG 254 Phytophthora paras...
NP_499971  26 ileT-LKSVNSTASLIIRKSVDSLSQCTRFCSSVPNCTHFTFSNAEPI----E----K-----KnggfnCHLH---SKSP 88  nematode
2F83_A    110 CNKDiYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPslehR----N-----I-----CLLKHTQTGTP 175 human
2F83_A    291 CHSSfYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQAS----C----Neg-kgK-----CYLKLSSNGSP 356 human
2F83_A     87 PRVNR-T-AAISGysFKQC 103 human
EDL35544  402 TRITYgM-QGSSGysLRLC 419 house mouse
BAF85313  177 TAIKVlS-NVESGfsLKPC 194 human
AAC24506  303 TKILHgR-GGISGytLRLC 320 human
AAA51985  176 TRITKlD-KVVSGfsLKSC 193 human
CAA65843  119 TRTPS-V-GAVSG--ILtg 133 Phytophthora parasitica
CAA65843  255 TATTK-I-GAVSG--TLN- 268 Phytophthora parasitica
NP_499971  89 VLTTS-G-SRTVG--TKTC 103 nematode
2F83_A    176 TRITKlD-KVVSGfsLKSC 193 human
2F83_A    357 TKILH-GrGGISGytLRLC 374 human
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