3EA3,1DJG,1AOD


Conserved Protein Domain Family
PLCXc
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smart00148: PLCXc 
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Phospholipase C, catalytic domain (part); domain X
Phosphoinositide-specific phospholipases C. These enzymes contain 2 regions (X and Y) which together form a TIM barrel-like structure containing the active site residues. Phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The bacterial enzyme appears to be a homologue of the mammalian PLCs.
Links
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Statistics
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PSSM-Id: 197543
Aligned: 18 rows
Threshold Bit Score: 146.657
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3EA3_A         19 DNIPLARISIPGTHDsgtfkL--------QNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIV-LHHGP-LYLY 88   Bacillus thur...
CAA58591      443 MSRPLNEYLISSSHN-----T--------YLLGKQFGGESSIEGYIRSLQAGCKCIEIDCWDGPNG-PV-VCHGHtFTSM 507  fission yeast
AAB39564      415 LDRPMHEYFISSSHN-----T--------YLMGRQVAGESSVEAYISALIKGCRCVEIDCWDGKDGRPI-VNHGHtMTRP 480  Botryotinia f...
XP_001169560  400 MTQPLSHYYINASHN-----T--------YLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPI-LCNRNnMTTH 465  chimpanzee
AAA74441      108 MTLPLSHYFIYTGHN-----S--------YLTGNQLSSDCSDVPIINALKRGVRVIELDIWPNASKDNIdVLHGRtLTTP 174  soybean
NP_015055     382 YSKPLNHYFIASSHN-----T--------YLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENG-PV-VCHGF-LTSA 445  Saccharomyces...
NP_190313     107 MHAPLSHYFIHTSLN-----S--------YFTGNVFGKYS-ILPIIEALEQGVRVVELDLWPDGRGSIC-VRPSWnFEKP 171  thale cress
ZP_06791181    27 DGKHLTEINIPGSHDsgsftL--------KDPVKSVWAKTQDKDYLTQMKSGVRFFDIRGRASADNMIS-VHHGM-VYLH 96   Staphylococcu...
AAS84871       54 dttnLAALSIPGTHD-----TmsyngditWTLTKPLAQTQTMSLY-QQLEAGIRYIDIRAKDNLN-----IYHGPiF-LN 121  Listeria mono...
1DJG_A        166 MDQPLSHYLVSSSHN-----T--------YLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPI-IYHGYtFTSK 231  Norway rat

3EA3_A         89 VTLHEFINEAKQFLKDNPSETIIMSLKKE---YEDMKGAEGSFSSTFEKNYFVDPIFLKTEG-----NIKLGDARGKIVL 160  Bacillus thur...
CAA58591      508 IKFNDVIDAIRKYAFVVSPYPLFISLEIHc-cPDQQRQMVSYMKQAFGDTLVMKPVTANESV-----LPSPEDLLNKILL 581  fission yeast
AAB39564      481 IMFSDVMYTIAKYAFVKSHFPLWISLEVHc-nDAQQAAMAQIIKEACGDLLVTEPLDPSSQV-----LPSPSQLMDRILI 554  Botryotinia f...
XP_001169560  466 VSFRSVIEVINKFAFVASEYPLILCLGNHc-sLPQQKVMAQQMKKVFGNKLYTEAPLPSESY-----LPSPEKLKRMIIV 539  chimpanzee
AAA74441      175 VELIRCLRSIKDHAFVASEYPVVITLEDHl-tPDLQAKVAEMVTETFGDLLFTPNSESVKE------FPSPESLKKRIII 247  soybean
NP_015055     446 IPLKTVIRVIKKYAFITSPYPLIISLEINc-nKDNQKLASLIMREVLAEQLYFVGTRTDK-------LPSPRELKHKILL 517  Saccharomyces...
NP_190313     172 LKLQECLDSIKEHAFTKCTYPLIITFKDGl-kPELQSKATQMIQQTFNHMVYHHDPH-SLEV-----FPSPQQLRNKILI 244  thale cress
ZP_06791181    97 HELGKFLDDAKYYLSAYPNETIVMSMKKd---YDSDSKVTKTFEEIFREYYYNNPQYQNLFYtgsnaNPTLKETKGKIVL 173  Staphylococcu...
AAS84871      122 ASLSGVLETITQFLKKNPKETIIMRLKDEqnsNDSFDYRIQPLINIYKDYFYTTPRTDTSNK-----IPTLKDVRGKILL 196  Listeria mono...
1DJG_A        232 ILFCDVLRAIRDYAFKASPYPVILSLENHc-sLEQQRVMARHLRAILGPILLDQPLDGVTTS-----LPSPEQlkgkill 305  Norway rat

3EA3_A        161 LKR 163  Bacillus thuringiensis
CAA58591      582 KVK 584  fission yeast
AAB39564      555 KVK 557  Botryotinia fuckeliana
XP_001169560  540 KGK 542  chimpanzee
AAA74441      248 STK 250  soybean
NP_015055     518 KSK 520  Saccharomyces cerevisiae S288c
NP_190313     245 SRR 247  thale cress
ZP_06791181   174 FNR 176  Staphylococcus aureus A9754
AAS84871      197 Lse 199  Listeria monocytogenes
1DJG_A        306 kgk 308  Norway rat
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