2QLV,2QLV,2V8Q,2V8Q,2QLV,2UV4,1JCN


Conserved Protein Domain Family
CBS
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smart00116: CBS 
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Domain in cystathionine beta-synthase and other proteins.
Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are associated with CBS-containing proteins including homocystinuria, Becker's and Thomsen disease.
Links
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Statistics
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PSSM-Id: 214522
Aligned: 60 rows
Threshold Bit Score: 35.9516
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2QLV_C      192 NMKSCQMTTPVIDVIQMLTQG-----RVSSVPIIDEn-----GYLINVYEAYDVLGLIK 240  baker's yeast
NP_442805   327 QMVTVNANQSLFEVAQLLDQQ-----KLSELLVVQPs-----GEVVGLLEKASIIKCLQ 375  Synechocystis sp. PCC 6803
YP_919813    94 DPPYVYTRSDLREVIELMVER-----GIGALAVVDEd-----LRVVGIVSERHVISLLA 142  Thermofilum pendens Hrk 5
ZP_06872922 259 KPVTITADKTLSEAIQLMRQE-----RVDSLLVVDGe-----HVLQGYVDVEIIDQCRK 307  Bacillus subtilis subsp. spizizenii ...
I40201        4 EFIRVTAVETVAEVIGRLRKEapdaeTIYYLYVVDEr-----EKLVGVVSLRDLIVAEE 57   Bacillus firmus
NP_595371   144 DFITIPHTTSLGRLAEILSSG------IRRVAVTNEq-----GELSFMASQRSIIRFLW 191  Schizosaccharomyces pombe 972h-
NP_595371    54 EIALIDPETSMEEASSILIDR-----DLSALPIVAAkg---sNEIATTFDYADLNSFLL 104  Schizosaccharomyces pombe 972h-
2QLV_C      116 DTASIHPSRPLFEACLKMLES-----RSGRIPLIDQdeethrEIVVSVLTQYRILKFVA 169  baker's yeast
XP_543685   128 PLVCISPNASLFDAVSSLIRN-----KIHRLPVIDPe----sGNTLYILTHKRILKFLK 177  dog
CAI15894    608 NLTYVYPHTRIQSLVSILRTT-----VHHAFPVVTEn----rGNEKEFMKGNQLISNNI 657  human
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