2A5Y,3CRD,3YGS


Conserved Protein Domain Family
CARD

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smart00114: CARD 
Click on image for an interactive view with Cn3D
Caspase recruitment domain
Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.
Statistics
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PSSM-Id: 128424
View PSSM: smart00114
Aligned: 14 rows
Threshold Bit Score: 69.674
Threshold Setting Gi: 7767041
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2A5Y_B         2 LCEIECRALSTAHTRLIHDFEP-R---DALTYLEGKNIFTEDHSELISKMSTRLER---IANFLRIYRRQASELGPLIDF 74  nematode
NP_502538      2 MRQDRRSLLERNIMMFSSHLKV-D---EILEVLIAKQVLNSDNGDMINSCGTVREKr--REIVKAVQRRGDVAFDAFYDA 75  nematode
AAC83232     439 keSNDLLLIRKNRMALFQHLTC-Vi--PILDSLLTAGIINEQEHDVIKQKTQTSLQa--RELIDTILVKGNIAATVFRNS 513 human
BAG51861       1 MAE---GNHRKKPLKVLESLGK-DfltGVLDNLVEQNVLNWKEEEKKKYYDAKTEDk-vRVMADSMQEKQRMAGQMLLQT 75  human
NP_001081223   1 MTA-QLNKVRRAIIDGCNPAMI-S---DLLDDLREKNVLVDSEVEHIKESNNTNRDr-cRAMIDSVKKKGDDPSNILLES 74  African clawed ...
AAC50640       1 MDEADRRLLRRCRLRLVEELQV-D---QLWDVLLSRELFRPHMIEDIQRAGSGSRRdqaRQLIIDLETRGSQALPLFISC 76  human
AAA56992       1 MAVRAKRKQFINSVSIGTINGLlD---ELLEKRVLNQEEMDKIKLANITAMDKARDl--CDHVSKKGPQASQIFITYIC- 74  house mouse
NP_116764     32 MHPHHQETLKKNRVVLAKQLLL-S---ELLEHLLEKDIITLEMRELIQAKVGSFSQn--VELLNLLPKRGPQAFDAFCEA 105 human
EDL92358       4 MQERPSETIDRERKRLVETLQA-Ds-gLLLDALVARGVLTGPEYEALDALPDAERRv--RRLLLLVQSKGEAACQELLRC 79  Norway rat
ABB58703      69 STSVKKDNHKKKTVKMLEYLGK-DvlhGVFNYLAKHDVLTLKEEEKKKYYDAKIEDk-aLILVDSLRKNRVAHQMFTQTL 146 human
2A5Y_B        75 FNyNn-QSHLADFLED 89  nematode
NP_502538     76 LR-StgHEGLAEVLEP 90  nematode
AAC83232     514 LQ-Ea-EAVLYEHLFV 527 human
BAG51861      76 FF-Ni-DQISPNKKAH 89  human
NP_001081223  75 LV-Kn-HKTLAKSLGL 88  African clawed frog
AAC50640      77 LE-DtgQDMLASFLRT 91  human
AAA56992      75 ---Ne-DCYLAGILEL 86  house mouse
NP_116764    106 LR-EtkQGHLEDMLLT 120 human
EDL92358      80 AQ-Qt--VSMPDPAWD 92  Norway rat
ABB58703     147 LN-M--DQKITSVKPL 159 human
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