1GR3,1O91


Conserved Protein Domain Family
C1Q

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smart00110: C1Q 
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Complement component C1q domain.
Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.
Statistics
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PSSM-Id: 128420
View PSSM: smart00110
Aligned: 17 rows
Threshold Bit Score: 158.62
Threshold Setting Gi: 143811421
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GR3_A        25 GVTGMPVSAFTVILS-KAYPAig----tPIPFDKILYNRQQHYDPRTGIFTCQIPGIYYFSYHVHVKGT--HVWVGLYKN 97  human
AAV38897     108 NIKDQPRPAFSAIR--RNPPMgg----nVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWE--ICLSIVSSS 179 synthetic const...
ABG79664     108 NIRDQPRPAFSAIRQ--NPMTlg----nVVIFDKVLTNQESPYQNHTGRFICAVPGFYYFNFQVISKWD--LCLFIKSSS 179 synthetic const...
XP_002811367 113 RYKQKFQSVFTVTRQtHQPPApn----sLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTA---NLCVLLYRS 185 Sumatran orangutan
BAC53585      83 NCHSKGTSAFAVKAN-ELPPAps----qPVIFKEALHDAQGHFDLATGVFTCPVPGLYQFGFHIEAVQR--AVKVSLMRN 155 Siberian chipmunk
Q02105       114 RYKQKHQSVFTVTRQtTQYPEan----aLVRFNSVVTNPQGHYNPSTGKFTCEVPGLYYFVYYTSHTA---NLCVHLNLN 186 house mouse
AAV38388     115 DYKATQKIAFSATRTiNVPLRrd----qTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRG---NLCVNLMRG 187 synthetic const...
Q06576        83 KCSSRPKSAFAVKLS-ERPPEpf----qPIVFKEALYNQEGHFNMATGEFSCVLPGVYNFGFDIRLFQS--SVKIRLMRD 155 Siberian chipmunk
Q06575        65 KCPCRERSAFTVKFSg-RLPPps----ePVVFTEVLYNTQRDLKESTGVFNCVEPGNYHFSFDVELYHC--KVKIGLMKN 137 Siberian chipmunk
NP_062600     55 VRSGSAKVAFSAIRStNHEPSemsnrtmIIYFDQVLVNIGNNFDSERSTFIAPRKGIYSFNFHVVKVYNrqTIQVSLMLN 134 house mouse
1GR3_A        98 GTPVM---Y---TYDEYTKGYLDQASGSAIIDLTENDQVWLQLPNaesNGLYSSEYVHSSFSGFLVAPM 160 human
AAV38897     180 RGQVR---RslgFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPk-kGHIYQGSEADSVFSGFLIFPS 244 synthetic construct
ABG79664     180 GGQPRdslS---FSNTNNKGLFQVLAGGTVLQLRRGDEVWIEKDPa-kGRIYQGTEADSIFSGFLIFPS 244 synthetic construct
XP_002811367 186 GVKVV---T---FCGHTSKTN-QVNSGGVLLRLQVGEEVWLAVNDy--YDMVGIQGSDSVFSGFLLFPD 245 Sumatran orangutan
BAC53585     156 GTQVM-------EREAEAQDGYEHISGTAILQLGMEDRVWLENKLs-qTDLERGT-VQAVFSGFLIHEN 215 Siberian chipmunk
Q02105       187 LARVA---S---FCDHMFN-SKQVSSGGALLRLQRGDEVWLSVNDy--NGMVGIEGSNSVFSGFLLFPD 246 house mouse
AAV38388     188 RERAQ---KvvtFCDYAYNT-FQVTTGGMVLKLEQGENVFLQATDk--NSLLGMEGANSIFSGFLLFPD 250 synthetic construct
Q06576       156 GIQV----R---EKEAQANDSYKHAMGSVIMALGKGDKVWLESKLk-gTESEKG-ITHIVFFGYLLYGK 215 Siberian chipmunk
Q06575       138 HIQVM-------EKHQLSKNEYENASGAMIMPLRQGDKVWLEADVe-tEEPDQA-KVVIYFSGFLIss- 196 Siberian chipmunk
NP_062600    135 GWPVI---S---AFAGDQDVTREAASNGVLIQMEKGDRAYLKLER----GNLMGGWKYSTFSGFLVFPL 193 house mouse
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