1V3F


Conserved Protein Domain Family
DEP
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smart00049: DEP 
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Domain found in Dishevelled, Egl-10, and Pleckstrin
Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).
Links
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Statistics
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PSSM-Id: 214489
Aligned: 44 rows
Threshold Bit Score: 37.6486
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1V3F_A         18 TSTGIRPSp-NMEQGSTYKKTFLGSSLVDWLISSNF-AASRLEAVTLASMLMEENFLRPVgvrsmgairSg--------- 86   house mouse
Q18239        488 EGSGLDIKd-RYWFKIPIPMSFLGTDLVEWLVKHVQgLETKKKAREFAEEMLKLGYIRPG---------V---------- 547  Caenorhabditi...
Q18467        279 PIDTQAWIq-HTNAMRGMPSIVEGSDLVEWLLDHVEgLRERKTARNFAADLLKLKYIAHV---------V---------- 338  Caenorhabditi...
O96838        324 QSNSLITL--HEEMQRDLPAQNCGQRLIEFLNSNNK-SANEVQAVAILNAMLAAGFLEPI---------Vpd-------- 383  fruit fly
Q9XTE2       1492 PYVGLKNTneKQMSVAHPANMFVVYDFALWLRYNVEeISKFEIAVNLIRRLADSKFIQVI---------Tskgkygsess 1562 Caenorhabditi...
XP_003354990  433 PESGLEVRd-RMWLKITIPNAFLGSDVVDWLYHHVEgFPERREARKYASGLLKAGLIRHT---------V---------- 492  pig
XP_002100876  379 PDSGLEIRd-RMWLKITIPNAFIGADAVNWVLENVEdVQDRREARRIVSAMLRSNYIKHT---------V---------- 438  Drosophila ya...
Q22227        427 PDSGLAVKn-RKWLKILVPMSFIGRDLVDWLVDHMAdIHNRKKARIYAARLLAAGLIRHV---------V---------- 486  Caenorhabditi...
NP_592988     214 lqeiplqDy-RVPILGTYPNTCSGNIIVSWLQENLP-VPTLVAAEAFGQDLIAQGFLRHM---------Gvgg------s 276  Schizosacchar...
EDN59103      218 PKTDYKLP----LISYSLSNTNNGGEITKFLLDHMS-LKDIDQAETFGQDLLNLGFLKYC---------Ngvgn-----t 278  Saccharomyces...

1V3F_A         87 -dLAEQFLDd--StALYTFAE 104  house mouse
Q18239        548 --GKQSFTK---E-CYYVMGD 562  Caenorhabditis elegans
Q18467        339 --NKVTFTE---Q-CYYVLGD 353  Caenorhabditis elegans
O96838        384 -pEQMDFDS---S-LHYKFSK 399  fruit fly
Q9XTE2       1563 lnSKKMFKF---K-AEYGFQL 1579 Caenorhabditis elegans
XP_003354990  493 --NKITFSe---Q-CYYVFGD 507  pig
XP_002100876  439 --NKLTFSe---Q-CYYVvne 453  Drosophila yakuba
Q22227        487 --SKLTFTE---K-CYYVFGD 501  Caenorhabditis elegans
NP_592988     277 fvNSTNFHYqwkD-KAFQFAG 296  Schizosaccharomyces pombe 972h-
EDN59103      279 fvNSKKFQYqwkN-TAYMFAN 298  Saccharomyces cerevisiae YJM789
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