2BON


Conserved Protein Domain Family
DAGKc
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smart00046: DAGKc 
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Diacylglycerol kinase catalytic domain (presumed)
Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Links
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Statistics
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PSSM-Id: 214487
Aligned: 28 rows
Threshold Bit Score: 79.263
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2BON_A       33 LLILNGKSTDNLPLr----EAIMLLREEGMTIHVRVTWE--KGDAARYVEeARKFGVA----------TVIAGGGDGTIN 96  Escherichia coli
AAB81538      7 LLIHNGNAANKNIE-----KALGAVVPVLSHHLDEVIIKqtKKKDHAYHF-CRSIDDSv--------dTVFILGGDGTIH 72  Bacillus subtili...
NP_215013    74 SFLWAPDPGTMRLV-----TSIRKRGRRISVADVELTQG--GRTAVHAVVtLGEPEHFl--------pGVDGSGGASGTA 138 Mycobacterium tu...
CAB04761    201 LVVVNPESGPDSVD------PSEEIATALPQAHVRALDTd-HDFAAQLDA-WVAEANPr---------ALGVCGGDGTVV 263 Rhodococcus eryt...
CBI83226     10 LVFINPNSGTGKSLetfanTVGPKLDKSLIRYEVVVTTGpnHARNVLMTK--ADLGKFn---------GVLILSGDGLVF 78  nematode
ZP_05224135   4 VLIVNPTATSTTPAg---rDLLAHALKSRLQLSVEHTNH--RGHGTELA--QKAVADGv--------dLVVVHGGDGTVS 68  Mycobacterium in...
NP_013361   272 FVIINPFGGKGKAKk---lFMTKAKPLLLASRCSIEVVYt-KYPGHAIEI-AREMDIDky-------dTIACASGDGIPH 339 Saccharomyces ce...
NP_442724   128 HLIFNPVAGQGNVEre-ldLIKEHLQSEINLKITFTSAEv-NVTDQAKEI-VKRIKQAneqsdgegdsFIIASGGDGTVS 204 Synechocystis sp...
EGA56724    230 LVIINPHGGKGTAKn---lFLTKARPILVESGCKIEIAYt-KYARHAIDI-AKDLDISky-------dTIACASGDGIPY 297 Saccharomyces ce...
NP_593818   109 IVFINPHGGKGKAKhiwesEAEPVFSSAHSICEVVLTRR--KDHAKSIAK-NLDVGSYd---------GILSVGGDGLFH 176 Schizosaccharomy...

2BON_A       97 EVSTALIQCEGD-Di---PALGILPLGTANDFATSVGIPEALDK------------------------------------ 136 Escherichia coli
AAB81538     73 QCINAISALERk------PAVGILPGGTSNDFSRVLGIPQNLAK------------------------------------ 110 Bacillus subtili...
NP_215013   139 PLLSANPVVELMaPe---PPEGVVPIGPGHQLAGLVHLGEGCDV------------------------------------ 179 Mycobacterium tu...
CAB04761    264 AVASAAARHSL--------PLAVFPGGTLNHFARDAGVAEISDT------------------------------------ 299 Rhodococcus eryt...
CBI83226     79 EALNGILCREDAfrifptLPIGIVPSGSGNGLLCSVLSKYGTKMn----------------------------------- 123 nematode
ZP_05224135  69 GVVNGLLGRPGTlPsgpvPAVAVVPGGSANVLARSLGISADPVAatnqliqllddyqrrgtwrriglidcgerwavfntg 148 Mycobacterium in...
NP_013361   340 EVINGLYQRPDHvKafnnIAITEIPCGSGNAMSVSCHWTNNPSYstl--------------------------------- 386 Saccharomyces ce...
NP_442724   205 GVAAALVNTGI--------PLGIIPRGTANAFSVALGIPTQIPGacq--------------------------------- 243 Synechocystis sp...
EGA56724    298 EVINGLYRRPDRvDafnkLAVTQLPCGSGNAMSISCHWTNNPSYaal--------------------------------- 344 Saccharomyces ce...
NP_593818   177 EVINGLGERDDYlea-fkLPVCMIPGGSGNAFSYNATGQLKPALtaleilkgrptsf-------------dlmtfeqkgk 242 Schizosaccharomy...

2BON_A      137 ---ALKLAIAGDAI-AIDMAQVNK 156 Escherichia coli
AAB81538    111 ---AAEALMAGKKTsVDVCQMNDR 131 Bacillus subtilis subsp. subtilis str. 168
NP_215013   180 ---RPVLSTLRSAT-DGRPPVIQL 199 Mycobacterium tuberculosis H37Rv
CAB04761    300 ---ANAVETGHAVL-VDQAVVHTD 319 Rhodococcus erythropolis
CBI83226    124 ---EKSVMERALEIaTSPTAKAES 144 nematode
ZP_05224135 149 mgvDAEVVAAVEAE-RSKGGKVTA 171 Mycobacterium intracellulare ATCC 13950
NP_013361   387 -clIKSIETRIDLMcCSQPSYARE 409 Saccharomyces cerevisiae S288c
NP_442724   244 tinRGITKVVDTAL-CNDIPMLLL 266 Synechocystis sp. PCC 6803
EGA56724    345 -clVKSIETRIDLMcCSQPSYMNE 367 Saccharomyces cerevisiae FostersB
NP_593818   243 kaySFLTANYGIIA--DCDIGTEN 264 Schizosaccharomyces pombe 972h-
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