Conserved Protein Domain Family
Peptidase_S80

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pfam20034: Peptidase_S80 
Peptidase S80 family
This family represents the protease responsible for the proteolysis of head proteins, a critical step in the morphogenesis of many tailed phages, Cleavage facilitates the conversion of the prohead to the mature capsid. All these cleavages are carried out by action at consensus S/A/G-X-E recognition sequences at 39 cleavage sites. Evidence of multiple processing sites in nine phiKZ proteins appears to represent a built-in mechanism by which the phage ensures that the majority of the propeptide regions are removed, and emphasizes the essential nature of processing in phiKZ-head morphogenesis. The family is classified by MEROPS as a serine peptidase.
Statistics
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PSSM-Id: 498481
Aligned: 18 rows
Threshold Bit Score: 283.401
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
YP_004958190   6 LGNIILAGTGKKGILAP-EANGTYLLNAGGFNIPNHAGITYPANEYvLDQINENSDLQRRVKMGYCKMEVEHPEpfiyvi 84 
2_pfamImport   1 YACTALVGTNKGGVLKP-DENGYYRMILGAFNIYNSAGLWYNYETS-KHIFDSSSSFMRRMSAGNLYSEEDHPQ------ 72 
YP_009290885   8 YNCVALAGVNKGATLKK-DADGYYYVLLGALNIFNSENIYYAYNES-KHVFERSNIFMRKVQAGNLFGEEDHPP------ 79 
YP_009278876   8 YNCVALAGVNAGASLQK-DSDGYYRVLLAALNVFNSEGVFYAFNES-KHVFDRSNVFMRKVQAGNLYGEEDHPP------ 79 
3_pfamImport   1 YESTVLQKSGKKGDLKK-DGE-YYEIVVGAFDCLNSREELYIFNNNiKRMYDPGGSFHRRMHKAVLRGEVEHPE------ 72 
YP_009010192   5 FECTVLKGVNNTGKIKR-LDNGYVEVVLGALEHPNSYGAVYDEGRA-REFLRQGSVFMRRISQGFLRGELGHPP------ 76 
YP_009212882   7 FSCQVLNGRNAAGTLKK-NSDGYYDMIVGALNMTNNKGEFYDYNYG-KKFFTEASDLVRMASKGVLRGEYGHPN------ 78 
YP_009820907   8 LVCTSYLGVNKKGIIRP-NADGAYTCVIGGFNCFNNTEEYYELERS-KPLFLENSLLQTNARNRSLKGEYGHPK------ 79 
Q2Z0N9         7 FENTLLANSGKRGILKPmDSSGYYRINAGGFNIPNRSGITYRVNDYiRECARPGSDFDRRVNEGQMYCEIGHPPqyykil 86  Pseudomonas pha...
YP_009612979   7 FGNVILAQSGKKGILRPiDDSGYYMLNAGGFNIPNRSGITYRANDYiYECMGPDSDLSRRVKRGEVYMELDHPPqyylek 86 
YP_004958190  85 engvkyRQPITDVLQWINRLRSYDPANICGLISEVLFNFDNpN--DVRAPIWNLIRCEPFGP---RREEFRESLANPRHN 159
2_pfamImport  73 ------WKDGQPLDMYVARIKRIEPKNICAHIRDIEVVPGD-MnkDGSQVMLIYGSVKPDRE---RGKFLKEALDNPDQN 142
YP_009290885  80 ------YEQGMSEAQWIERNEWIETKNVCMHIREVEVKPTD-QvcNGLPVMEIWGWVKPNRE---RGPLLAEALENPHQN 149
YP_009278876  80 ------WEQGMSDSAFMERNEWIETKNVSHHIREVELVNTT-QtcNGMPVVEVWGWVKPNRE---RGPLLAEALENPHQN 149
3_pfamImport  73 ------FKPGMSLDQYLNRIRQIPLTNSSHHFRQIRLESG--KdeNGKPIVLAIGSVRKSGE---KGHVFQDAIDNREEN 141
YP_009010192  77 ------QRECRDYNDYVERIHTILEKNVAIHIRKVWIDSNH-VlnDGRKCIAIMGEICPDGP---HAHVVERLLNNPSAN 146
YP_009212882  79 ------QETGQSDDKFVERLLRIDEKSACCHHKKIYLDFDRyKdgQGRPIVGIMSAVAPSGP---YGDALDKQINNGSEN 149
YP_009820907  80 ------PEIGQDATSFLQRALRIEETKVSHCFSKIWLEEAG-RdrRGRPVVMVMGDVIPCGP---YGDPLRKDFETPLVN 149
Q2Z0N9        87 vngevvRKQITDLFEWINRLRTIDFDNVCGHIRKVHWIFTG----GPNDPVYNDIEVIPWAKnphHKQLLQESLDNPDIN 162 Pseudomonas pha...
YP_009612979  87 ingqvvRTRITDVFEWILRLRTICMDRVCAHIRKIHWDITG----DRGAPIYNRVETTPFGP---FKEMFQQSLDTPDIN 159
YP_004958190 160 TAVSIRTQIS-PFRPGDTQKNVEFWTGYDWVSEPGMVHANKHMTAGCESflndfgl---ndnmqkfSTSEMIERLDGALA 235
2_pfamImport 143 VCFSLRALCDdKYINGRIERTITEFITFDWVVEPGLHVAHKYNAPGLESfa--------------cESREEMPIPIEAIE 208
YP_009290885 150 VCFSLRAIVReGRIGGQVVRRIDKLVTFDWVIEDGLQICNKYSAIQRGSkvaq----------estRTYVDRPISMEVLE 219
YP_009278876 150 VCFSLRAIVReKRVNGVVTRRIDKLITFDWVIEDGLQICNKYSAMQRGSkvaq----------estRMYLDRVITREALE 219
3_pfamImport 142 VCFSIRAMSKrWNDMGQVKREITSVITYDLVGEGGILCANKYDTPSMEC-----------------FSQEELPFTEADLV 204
YP_009010192 147 LAFSIRSMATdKYVAGKKRKYLDAIITWDVVNEPGLDVATKYNSPSCES-------------------FQDIERVAANLP 207
YP_009212882 150 VCFSIRCFSMpHKVGGRIIKEMKHVVTFDYVNEPGIAMATKYDSPSLES-------------------HASKIFTEGSVR 210
YP_009820907 150 VCFSVRALTDpQIWQRERRRVMTRVMTYDYVNLPGIEFATKYDSPTMEGfqkdve-----qeakaiMDAYDLPITAPMVD 224
Q2Z0N9       163 TAFSIRTVTK-PQNFGDKTREVDYWSTYDAVIEQGILRACKHLTAGLESllddysae-ggemefttTMEELFFICDQKMR 240 Pseudomonas pha...
YP_009612979 160 TSISVRTVTK-PQKVGDRTREVDYFTGYDYVPEPGMDRANKHMTAGLENylqdgalafgednelttDFDAMIYMVESTMS 238
YP_004958190 236 EADKNAEAlIRV--GGMEALDd-YRQIL 260
2_pfamImport 209 SLIAKKAQ-MQAqgIGLESDE--DYTRL 233
YP_009290885 220 DIIYNPTA-VST--VATES----RRGAL 240
YP_009278876 220 DILYSARE-KTL--VGTEST---RQNQL 241
3_pfamImport 205 AAEAWADKlEEK--LALESEPevSFTMI 230
YP_009010192 208 VIRAMAER-RTSqgVAVESSIaqTLDAV 234
YP_009212882 211 QSARNIRQ-RPG---SNESVSv-PLGAL 233
YP_009820907 225 ELVVRSGG-QHA--LAMLSGDs-PVVFL 248
Q2Z0N9       241 SPEVAERY------AGTESFVr-VQEML 261 Pseudomonas phage EL
YP_009612979 239 NPTVMQRF------EGTESLKe-LGDML 259
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