Conserved Protein Domain Family
GASH
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pfam19994: GASH 
GTPase-associated system helical domain
This entry represents a Helical domain observed in the GAP1-N1 type of GTPase-centric ternary systems, a class of NTP-dependent biological conflict systems. GASH is one component of the GTPase-activated complex in these systems, potentially involved in the sensing of invasive elements.
Links
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Statistics
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PSSM-Id: 498458
Aligned: 14 rows
Threshold Bit Score: 197.733
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_058029518   5 LDSFLS--LGLIDSIDGNDERYAKIEQAAQKLAEY---YREEPEQLIP-----AILCGLNPNVSLDELPINKAKELLQNE 74  Pseudoalteromon...
WP_146678871   5 IQQFLD--AQLFN-IADNEERLEKLLASAESLSDA---FIENNSLLLQ-----FLRASLVPNVDENSLVLSQIEAHIKKD 73  Pirellula sp. S...
WP_038698918   2 LQSYLN--ATLLP--VTDEGDFRKLKKSADDLAKR---LLKNKHKILS-----FTLTALNSDVSVEDPDVIEVNEIIIKN 69  Sphingobacteriu...
WP_058248885   6 LQGFLV--KGLID-VGGDDTKLEKLSQAAKDLASA---LKKKPSKALS-----YSLIAFDPDAPEDDPVVQEALAALQKR 74  Tropicibacter n...
WP_009454311   6 LLKFLE--IGAID-LKGDDTKLERLRSTAKDLSAA---LRKAPSKTAC-----FTMVAADPNIAATDPTVEEAMASLRKQ 74  Alcaligenes sp....
WP_012406440   6 AQYLLR--LHSTIGITADAATIDRRSASIDALAAN---ITVEQTIAAA-----AVSTGLVADLAK----VRELLQPVSDS 71  Paraburkholderia
WP_119765519   2 SGNIGA--WYRGAAIGKDEERLTHRRTASVTLAAS---IEKMAARDVAgv--aAYGLGILTGSGAPSPYAATIIERMQGP 74  Sphingomonas ca...
WP_114878795   1 MYDIAE--HIRIFEANPSDDFVTKREAAIKTVISK---LRKSVSFDELleladDISTCLFDLKIAESSVCDQVIEALKSK 75  Sulfitobacter s...
WP_066538964   1 MKTLLRkcYQEVGIAGANATTFENRISAIEHLLSVddfFTNYEWMSLT-----KWAMGVVEDENTES-LLVRLEEEFCRT 74  Acutalibacter m...
WP_029095771   3 DYNFAD--QYRAAGLAPGSDIIRLRQSAFDDLREN---LNIDNILDLT-----RIYFGLTVPSGTDW-----FRNAFSEN 67  Budvicia aquatica

WP_058029518  75 WKAFLTAYTD--EPVNLYRSIILEACFLVSEENNN--------AAIIWLTACDAFPLLK-CGKEESLLRTFLQSLGRTAE 143 Pseudoalteromon...
WP_146678871  74 WSTFLSAQRE--RPTAINLAVGWQAARRASEKDTEl-------CALLWYGSANLLLDSK-VDPLSNLVIDFVKSQGVELE 143 Pirellula sp. S...
WP_038698918  70 WTTFSTNSKS--TPLTFIRAVIFETLNNISEDINi--------ALIIWLSSRNIYRYTKfTGNEKIIVEKFLSKLASNIN 139 Sphingobacteriu...
WP_058248885  75 WVTYRNTFAD--MPISVVRAILLDAIVDAATEDDRv-------GVCFVASARNALPLMP-VDSERDIWIDIVKKIERRVD 144 Tropicibacter n...
WP_009454311  75 WETVANAFAR--RPVGILRAILLDAIMQAARSDDAi-------AVAFVNTARNALVHAE-TANESEIWREAVSEIEKKVD 144 Alcaligenes sp....
WP_012406440  72 DPGFAPVQVD--KAAAVVCSAVTNKLLAGGGTRGLt-------AALVVLCASMGQATQHvDERLRAIAQQQLWAIQRTAA 142 Paraburkholderia
WP_119765519  75 QPSLSEEDAAaeGDARICTLAAIEKMIEDRAAKPNr-------LMRKEPAIVAAEAIVCaTRMRVVSAGSNLAGKLGELI 147 Sphingomonas ca...
WP_114878795  76 SSSFSAKENE--LQIAVCAALAVLKLIQDSPAASGrvttivflSFALWSALSDRKPIK--DEKLEKLRLEVLDSARDLTL 151 Sulfitobacter s...
WP_066538964  75 DNSFSLANT---KEMHILVEFLIFQYCQNSENTLLl-------SMVICGHCVGW------KTRSKLLYQKMIDYINNVRL 138 Acutalibacter m...
WP_029095771  68 DLSFSMIDNE--REAAVLAVCLLSASLSDGNINAGl-------VPIVTAIN---------RHRSPVLQPNFLNEAFHRLD 129 Budvicia aquatica

WP_058029518 144 QNAIV--SGPelsfrkekpIKLDAPSDLAiFDKDSDDNDLFELIAGA-AGPQytdergqnvttqnpnrywahsnpqawvr 220 Pseudoalteromon...
WP_146678871 144 RRAVAe-wSP---------YTAKTIKQVKaVAMVEVKNTLQIPLLKAsAAVDpstgsaveggnt-----hqpstdgnwaa 208 Pirellula sp. S...
WP_038698918 140 SEANLvwGLNsldirdsveITLQTV-----PAYLLNKVEFQKLLEDAsGPTNsedksnydspnt-----sfpdegaawsy 209 Sphingobacteriu...
WP_058248885 145 EVAEKewATPetisiksmkYQQPSIGSPKiTFGEVSEADLQIALRAA-AGPHdqsnnptngnry-----fpnqnpanwvs 218 Tropicibacter n...
WP_009454311 145 ARAEAewATPetitvdpfqYTAPSPVSTSyEAPTVNKSELRENIYSA-AGPWgasnsnqyhs----------sqpqhwap 213 Alcaligenes sp....
WP_012406440 143 PEAKYiaPQP---------------------------------------------------------------------- 152 Paraburkholderia
WP_119765519 148 SSA----------------------------------ETLLTQLDAG--------------------------------- 160 Sphingomonas ca...
WP_114878795 152 RSA----------------------------------------------------------------------------- 154 Sulfitobacter s...
WP_066538964 139 SLR-----------------QFNSDLSIRtIDIQIPIQTIITLLEPE--------------------------------- 168 Acutalibacter m...
WP_029095771 130 ELSikseq---------------------------------------------------------------------gcc 140 Budvicia aquatica

WP_058029518 221 dFASRMSEILTCEINNIEEQLVVNSKNSLesls---slkNSVEKALNEQRLTLQRQQKEFLNYQKQEQTRINVLWWAEAL 297 Pseudoalteromon...
WP_146678871 209 fFSKHASSGITNSIAQVTKAVLESVQSSI----------DDLSKKVTATSAELNRS-------HTAQSRRTELLWLSESL 271 Pirellula sp. S...
WP_038698918 210 eFAPRAAAGIKKIVDRSLEVIVKNIN-------------ENNIVVQNALKGGATKFQNDLVLQNRSLNLRSELLWWKEAG 276 Sphingobacteriu...
WP_058248885 219 eFGDMSGTAISDAINSAISEVAVSDPDLS----------EPFGNLVSAVSGYVDEALNSFSAATAGLQRRTKLLWWREAL 288 Tropicibacter n...
WP_009454311 214 iFADKMSVAIAEVLNGMAEELAPAPVDLS----------GPLSQLAKAVTTHVDKALASFSGATAGLQRRTNLLWWKEAL 283 Alcaligenes sp....
WP_012406440 153 ---QVTAEQIKALIDTLAAGNVANTTAPMqv------vaDGILAALAAQSAAVGKAFEALSVRQAIVEDETRMQWWVVGK 223 Paraburkholderia
WP_119765519 161 ---RRTRRVVKPTLTTLKGAAD-----------------------LEGVKAEAAKAIEGIWLDSHLDREELQALWWVFSG 214 Sphingomonas ca...
WP_114878795 155 ----------------NSGRVRAKIPDLKwpse---avaGEDDTRAQDFDAAAKSAIGALETNSSLDREELDLLWWVLGS 215 Sulfitobacter s...
WP_066538964 169 ---NEDDEAREEQIAQLTGELEKD----------------------NVQLHKLTEQIHELNSALLVQREESDILWWMLTE 223 Acutalibacter m...
WP_029095771 141 iTVDKIETPKECQISTDIDDFEESPTDILklaeivrtahEASSEASKTIVKQVTDVVYPLVERVDMLREEVSMLWWYIGG 220 Budvicia aquatica

WP_058029518 298 YSASQKESYRSYTPEMAAVLMPYDLLEEIQLPSPAS--VVFTLSEAVGKLPECSHE---RDYSFYEVLTEI-RNKRSQFD 371 Pseudoalteromon...
WP_146678871 272 YSTRLKKGYRELTPNETIVSLTSDVAEIATGLSPQS--VEYFLADKISRLLPS------DEIKLESFVREL-SGSAVRVA 342 Pirellula sp. S...
WP_038698918 277 YSVAMDAGYHEVNSSVIDIVMAFDYSNFIPIIYPKS--VDYFFRSTVKGIVSDGEDlvdLKQFFKGLIDNS-TYLKSLFP 353 Sphingobacteriu...
WP_058248885 289 YSPSAAKSYRELSPTTAAALMALDLFETVPLFTPAS--VSAFLGETVLRLGAETVE---AQKTICELVKEA-QDHDDLSP 362 Tropicibacter n...
WP_009454311 284 YSPSVHASYLDLPLFEASALMALDLHEQVPTYSPAS--VSAFLREAIRCLPAEKDDqdnGERDVASLVHDA-RTAAFMRP 360 Alcaligenes sp....
WP_012406440 224 ASAELFRPFAALPPFEAAARAASDLSAMVSRMRPAGpfAAPALLERVLHADDPARS---NAKPFAEAIVGI------PLA 294 Paraburkholderia
WP_119765519 215 FSPTLLQGYETLTKAKAAVASGIDLAGLLEWPGTKA--FAELATRASGANLHAP-----DAAPENGALSALtDDDLTPLT 287 Sphingomonas ca...
WP_114878795 216 WSGIAKSRLDSLSELNRALISGVELSKLLRRVPGDA--HRHLVLRGVRED---------KEFTLNEVLTEL-GELKQALA 283 Sulfitobacter s...
WP_066538964 224 WSETCQKSYRDMNQVEAALFSVYELNYHVKFALGPY--AAKQILIKMVSLAKPGGS---ESPTVASLIDSLdGSTLPEFE 298 Acutalibacter m...
WP_029095771 221 WSRKLNKPFADLDIGLAALMAGLDLAHLTQRKNGPI--AARAILQRVFIDCRSKPK---KEITLDSAIESLpDTLIGLLD 295 Budvicia aquatica

WP_058029518 372 SCWLETLTSRADEKNSNIGGLVVRALID-----ENCDLASLIEESFIPQE-------WRCSLPELSRAIFRQEQAYRL 437 Pseudoalteromonas...
WP_146678871 343 LP-TQLFIPIQGTKRIGLLEFAGALAAG-----QT-DIKKFIECTGFPKS-------KSMSASALARWVFREIKCAEC 406 Pirellula sp. SH-...
WP_038698918 354 EM--------SAESKIPLLNFIVGMIY------NKYDVEELESRVGINTD-------IDIRRVDLALWLFHDLQLQKT 410 Sphingobacterium ...
WP_058248885 363 LRAIAAKLADVPEGRGPLLALIGHPAHA-----NARREEDFQRLTGLSPS-------SKLDPVSWAGWLFRELQASKA 428 Tropicibacter nap...
WP_009454311 361 FRALATQYVPEPVGRGPLLSLIGHTQNS-----GVIEATTLRALVGVDAS-------TKMTPSEWGTYLFRELQSARA 426 Alcaligenes sp. E...
WP_012406440 295 ERPAILKNKPSTTNVPGAFPIMLAAEYSiesgdEEDWQPRFKRAAHVDVH-------TKITPVEFAEQLYREFLLWKL 365 Paraburkholderia
WP_119765519 288 HG--------SSTDEFPDLNVLIPLTAA-----------SFVRSTGADSSnalagmrQDLSYADLARQSFAECSLLTV 346 Sphingomonas cave...
WP_114878795 284 QGVNASDLIEENAAALPLLNAICVSPE-----------------GSIFGN-------RKLKVSDWGARALMEAALIRM 337 Sulfitobacter sp....
WP_066538964 299 EC--------NITEFQPILSALKAKKEVfhkerNSEWMKHYEMRCKKELDn------LSMTAVEFGQQLYREIELGRQ 362 Acutalibacter muris
WP_029095771 296 FP----EKLKSMEDLCPVSSAIVKYQVIg---gNAAWHAQFKKSTALDPT-------ILFTPIELSMQIYRESLLLSN 359 Budvicia aquatica
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