Conserved Protein Domain Family
DUF6421

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pfam19985: DUF6421 
Family of unknown function (DUF6421)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000877) is described by MIBiG as an example of the following biosynthetic class, other (unspecified), in particular the polyoxin A biosynthetic gene cluster from Streptomyces cacaoi subsp. asoensis. This family appears to be predominantly found in Actinobacteria.
Statistics
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PSSM-Id: 498450
Aligned: 21 rows
Threshold Bit Score: 768.448
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_120059685  32 SAAWLSLKAAATALQPLQAQDGSVPDAAD----HAEARGHVAAITAAIEELRPLFPHDDAYLAASVRDFATWADGGFGVP 107 Nocardioides ca...
WP_055896444  41 DPQWAALKAAAEAIRPHQVKDGSIPDESV----HAEAAHHVGVIVESLRHFAPRIPYDTDYLLAAARDFEAWRDGGFAVP 116 Yonghaparkia sp...
WP_106212739  30 SELWLGLKGAADGIRRLQAHDGSIPDAAQ----HSDARRHCENIATRLAAFARVFPHDSAYLLAAAADFGRWAGTGFGVP 105 Glaciihabitans ...
WP_119869372  23 SPEWLDLKSAAVELQGLQAQDGRIPEPAD----HARAGELTARLAASILRFRAVFPHDADYLTALARDFDRWAAEGFGVP 98  Frondihabitans ...
RKT79574     205 DPAWLRLKAAVSELRLLQQKDGSLRDDVDea-gHERARTLVAEVVAGIRGLAPSLPHDAAYLEALVLDFGRWVDGGFGVP 283
SNV19910      48 HPAWISIREAATSIQALQSSDGSITEATE----HAKARELITHITQGIEELAPLLPHDADYLTAVRSDLHTWANNGFTVP 123
WP_078978094  15 HPQWPVLKEAVADLRPLQAKDGSIEPSG-----HAAARVLVADITAAIAALAPLFPYDEAYLDAVVADFHRWAEADFARP 89  Embleya scabris...
WP_182311468  22 NPAWAVLKRAVEAIRPHQSKDGSIDFAADgapaRADVEKELARVVEAVQELAPALPHDADYLQALVKDLVKWGESGFAVP 101 Streptomyces
WP_014134848  30 HPAWPRLKDAVEALRPLQSKDGSIDLAAVp---RATVDPLVATVRDAVAELAPLFPHDAAYLDAVRADLAKWADTGYRQP 106 Kitasatospora s...
WP_042452484  21 HPAWLRLKAAVEAMRPLQSKDGSIDLNSRgastKDEADAQLAAITAAIGELAPLFPHDKAYLDAVVLDLMRWAASGYAVP 100 Streptacidiphil...
WP_120059685 108 DFLDSLVAFQPQEHRVDGLRHLVVFPMYTQNGSSDRHVEALLVEVIWPEFIAHLEAGDYGNRLFVPLRLLDFTSGYDTNS 187 Nocardioides ca...
WP_055896444 117 DFYDALDAFRPADQRRDGVAHLVVFPMYTQNGSTDRLVEAVVFEVIWPDFIAELEAGEYGNALYLGLRFADFTPGYDTNS 196 Yonghaparkia sp...
WP_106212739 106 DFLDALLAFQPQQNRVDGLRHLVIFPMYTQNGSTDRLVEAVLVEVIWPDFVGELEAGDYSNALFVPIRFLDFTDGYNTNS 185 Glaciihabitans ...
WP_119869372  99 DFLDSLTAFQPQRDRVDGLGHLVVFPMYTQNGSTSRLVEAVLVEVIWPEFIAELEAGPYSNALFVPIRFVDFTPGYDTNS 178 Frondihabitans ...
RKT79574     284 DFLDSLNAFAPAQHRVDGLTHLVVFPMYTQNGNPDRMVEAVLLEVIWPDFVAELEAGDYSNRLFLPIRFLDFTAGYDTNS 363
SNV19910     124 DFLDSLVAFHPELHRVDGLVHLVVFPMYTQNGSSERHLEAVLIQVIWPDFVAALEAGDYTNAAFVPIRFIDFTAGYDTNS 203
WP_078978094  90 DFLDSLVAFRPEQNRRDGLEHLVVFPMTTQNGNPNRNVEAVLLRVVWPQWLADLEATRYDNAMFVPLAFVDFTDGYDTDS 169 Embleya scabris...
WP_182311468 102 DFLDSLLAFRPASQRVDGLEHLVVFPMYTQNGNPDRNLEAVALRVVWPEWLSELERTRYDNPLFVPITFQDFTAGYDTNS 181 Streptomyces
WP_014134848 107 DFLDSLLAFRPNEQRVDGTGHLVVFPMYTQNGNPDRNLEAVLLKVVWPDWIAELERTRFDNPGYLGIAFEDFTAGYDTNS 186 Kitasatospora s...
WP_042452484 101 DFLDSLLAFQPAEQRVDGLAHLVVFPMYTQNGNPDRNLEAVLLHVVWPEWLSELERTRYDNPMFVPITFVDFTAGYDTNS 180 Streptacidiphil...
WP_120059685 188 AVLFPETVAV-------------RETP-QFTWGAIFQDREAARFRRVVGAASAITDLALPEGAARMLEDQALTEKAFVVW 253 Nocardioides ca...
WP_055896444 197 AVLFPESVAVtprvpagapegtpAQLP-VFTWGAIFADREAARYRRVVRAAAEITKLDLPEGARRMLDDQELTERTFVMW 275 Yonghaparkia sp...
WP_106212739 186 AVLFPESVAM-------------RAIP-TFTWGAIFADREAARFRRVLREASAITRLELPAAAARLLEDQALAEETFVMW 251 Glaciihabitans ...
WP_119869372 179 AVLFPESVAM-------------RAVP-TFTWGAIFADREAARFRRVLRAAAGITKLDLPSGAERLLDDQRLAEETFVLW 244 Frondihabitans ...
RKT79574     364 AVLFPETVAM-------------REVP-AFTWGGIFADREAARFRRVVAEAADVTRLSLPADAARLVADQQLAERTFVMW 429
SNV19910     204 AVLFPETVAV-------------RAIP-QFTWGGIFADREAARFRKVLAAACEITSLDPPEEARAFLDDQRLTEETFVMW 269
WP_078978094 170 AVLFPETVAV-------------REVP-RFTWGGIFCDREAARFRRVGTAAADTLGLELPPEAQALVESQQLAQNAFVLW 235 Embleya scabris...
WP_182311468 182 AVLFPETVAV-------------REVPdSFSWGGIFCDREAARFRAVSDAAVRTLGLELPEDAARLIADQELAMETFVLW 248 Streptomyces
WP_014134848 187 AVLFPETVAV-------------REAPeRFTWGGIFCDREAARFRAVTTSAVRQLGLDIPADAAGLLGDQDRTQQTFVLW 253 Kitasatospora s...
WP_042452484 181 AVLFPETVSV-------------REVPeRFTWGGIFCDREAARFRAVSNASVNTLGLTIPEDAAALLADQELAQQTFVLW 247 Streptacidiphil...
WP_120059685 254 DLIHDRTHMRGDLPFDPFMIKQRMPYFLYSLEELRCDLTAFRECVWVEQQltarrdesgsrdgvgglETIEVETLEHAKL 333 Nocardioides ca...
WP_055896444 276 DMIHDRAHMRGDLPFDPFMIKQRMPFFLYTLEELRCDLTAFREAVRLRRD-----------------DATDAVTREHAQL 338 Yonghaparkia sp...
WP_106212739 252 DLIHDRTHMRGDLPFDPFMIKQRMPYFLYSLEELRCDLTAFREAVRLQRA-----------------DATDEVTRDRAIL 314 Glaciihabitans ...
WP_119869372 245 DLIHDRTHMRGDLPFDPFMIKQRMPFFLYSLEELRCDLTAYREAVRLTRD-----------------VETDDVTRERAQL 307 Frondihabitans ...
RKT79574     430 DLIHDRTHMHGDLPFDPFMVKQRMPFFLYALEELRCDLTAFRESVKLE-----------------------AEGHPYARM 486
SNV19910     270 DLIHDRTHMRGDLPFDPFMIKQRMPYFLYSLEELRCDLTAFREALRIERIiaas----------pdvSDEQRSLARHARL 339
WP_078978094 236 DLIHDRSHMRGHMPFDPFMIKQRMPFWMYALEELRCDLTAFREAVALSA------------------EG-----EPTAPL 292 Embleya scabris...
WP_182311468 249 DLVHDRTHSHGDLPFDPFMIKQRQPFWMYALEELRCDLTAFKEAVKLEA------------------EG-----YPQGRN 305 Streptomyces
WP_014134848 254 DLVHDRTHSHGDLPFDPFMIKQRSPFWMYGLEELRCDLNTFKESVALEA------------------EG-----TPQGRD 310 Kitasatospora s...
WP_042452484 248 DLVHDRTHSHGDLPFDPFMIKQRSPFWMYGLEELRCDLTAFKAAVELEA------------------EG-----NEHGRN 304 Streptacidiphil...
WP_120059685 334 VQYAVIFDRIFRFAITGSRVRNYDGLGGQLLFAWLHQRGVLHWTDTSLAFDWDDVPAAVVALGDAIDELYWRSIDRPKTA 413 Nocardioides ca...
WP_055896444 339 VQYAVIFDRIFRFSITGTRTRNYDGVGGQLLFAWMHQKGVLHWTDTQLAIDWDAVPDVVVALSDAINELYWSSIDRPKGA 418 Yonghaparkia sp...
WP_106212739 315 VQYAVIFDRIFRFAITGTRVRNYDGLGGQLLFAWLHQHHVLHWTDTQLTIDWDGVPDAVLALGQRIDDLYWRSIDRPKAA 394 Glaciihabitans ...
WP_119869372 308 VQYAVLFDRIFRFAITGSRVRNYDGLGGQLLFAWLHQHHVLHWTDTSLAIDWDEVPDVVIALGHEIDDLYWRSIDRPKVA 387 Frondihabitans ...
RKT79574     487 VQYAVLFDRIFRFSITGSRVRNYDGLGGQLLFAWLHQRGVLHWTDNRLSVDWEAVTEPVLELGRAIEDLYWRSIDRPKAS 566
SNV19910     340 VQYAVIFDRIFRFTVTGGRNRNYDGLGGQLLFAWLHRKGVLHWTDTKLTFDWDRVPDMVNELGDAVNDLYWQSIDRPKVN 419
WP_078978094 293 VRYAVIFDRLFRFPVTGGRVRNYDGLGGQLLFAYLHRAGVLDWSDNRLTIDWDRITDAVLGLFDEVDRLYREGVDRSKVG 372 Embleya scabris...
WP_182311468 306 VQYAILFDRLFRFPVTGDRVRNYDGLGGQLLFAYLHKHDAVRWTDNTLRIDWKLASEVTNRLCAEIETLYRDGIDRPKVV 385 Streptomyces
WP_014134848 311 VQYAILFDRLFRFPVSGDRVRNYDGMGGQLLFAYLHKHDALRWRDNRLTIDWDRVAEVTNGLCAEIETLYRDGIDRPKTA 390 Kitasatospora s...
WP_042452484 305 VQYAILFDRMFRFPVSGGRVRNYDGLGGQLLFAYLHKHDALRWTDNKLHIDWQRAPQVTNDLCAEIEKLYRDGIDRPKTA 384 Streptacidiphil...
WP_120059685 414 HWLAAYELIRSTLTPNPASVWA-R----GLPDEIL------AGPTKGYTDAVLDDEFPLSMFYESLDKKMRPVIESTAGI 482 Nocardioides ca...
WP_055896444 419 HWLAAYELVSSTLTPHPASQWA-A----GLPRAVL------EGPLKGWTDLVMDDEFPLSMFFEALQKKMALVIESTAGI 487 Yonghaparkia sp...
WP_106212739 395 HWLAAYDLVSETLTPHPASRWAvR----DIP---L------EGPPRGLTDAVMDDEFPLSMFYEALHKKMSPVIESTAGI 461 Glaciihabitans ...
WP_119869372 388 HWLAAYDLVSSTLTPHPASRWAaR----DLP---L------AGPPKGYTDAVLDDEFPLSMFYEALAKKMAAVIESTAGI 454 Frondihabitans ...
RKT79574     567 HWLAAYALVSSVVTPHPSSAWA-RhaagDLTALPL------DGPPKGLTDAVLPDEFPLSMFFEALAKKMKPVIESTAGI 639
SNV19910     420 HWFAAYDLVASVLEPHVASKWAtR----DLP---L------NGTPRELTDAVLDDEFPLSMFFEAYEKKVRDVIASTKGI 486
WP_078978094 373 HWLAGYRLVAEYVPSHPGSVWA-K----GTAALPM------DGPPKALVDAVLPDEFPLSMFYEALNRRLRDVIASTRGI 441 Embleya scabris...
WP_182311468 386 HWLAAYELVSTYVSPHPASVWA-K----GPEALPL------DEPPRRLVDQVLADEFPLSMFYEALNKKLRDVIASTRGI 454 Streptomyces
WP_014134848 391 HWIAAYQLVSRYLTPHPASTWA-K----GPEALPLdla-ddRALRKALCDAVHPDEFPLSMFYEALSKKLRRVIAGTKGI 464 Kitasatospora s...
WP_042452484 385 HWLAAYELVATYLTPHPASTWA-K----GAEALPFaqhteaKALNKALCDAVLPDEFPLSMFFEALSKKLSGVIASTSGM 459 Streptacidiphil...
WP_120059685 483 VGT 485 Nocardioides cavernaquae
WP_055896444 488 TGA 490 Yonghaparkia sp. Root332
WP_106212739 462 TGV 464 Glaciihabitans tibetensis
WP_119869372 455 TGT 457 Frondihabitans sp. 762G35
RKT79574     640 TGR 642
SNV19910     487 TGE 489
WP_078978094 442 TAD 444 Embleya scabrispora
WP_182311468 455 TAR 457 Streptomyces
WP_014134848 465 TGT 467 Kitasatospora setae
WP_042452484 460 TGT 462 Streptacidiphilus jiangxiensis
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