Conserved Protein Domain Family
DUF6417
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pfam19981: DUF6417 
Family of unknown function (DUF6417)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000087) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the lasalocid biosynthetic gene cluster from Streptomyces lasaliensis. This family appears to be predominantly found in Actinobacteria.
Links
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Statistics
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PSSM-Id: 498447
Aligned: 12 rows
Threshold Bit Score: 68.5999
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_067237649   1 MDDYDVfdLQDSDFAPV--------------------------------------------------------------- 17  Streptomyces lo...
1_pfamImport   1 APAEEA--LFPGAPRPAdaraarispdgldalawrharthtappspawaakaadpawreialqpaemlllrryahllpdl 78 
WP_109378876   1 MDDDEHldPEESGYAPV--------------------------------------------------------------- 17  Streptomyces sp...
WP_053764138   2 SDDYEHddLDDIEFAPV--------------------------------------------------------------- 18  Streptomyces
WP_063797295   2 NDDYEPpdLDDMDFAPA--------------------------------------------------------------- 18  Streptomyces
WP_043447034   1 MDDYRHieLDGIAFVPA--------------------------------------------------------------- 17  Streptomyces no...
WP_057578219   1 MDGYDHldLDEIDFAPV--------------------------------------------------------------- 17  Streptomyces sp...
KPI22839      56 ADRETRaeLSAWEGRPVrwavrlsatghdllayagvrpaptplepgpgerlve----------lapsqmtalrvfaglag 125
KUN77674       4 ADRETRaeLSALRGRPVrqavrlsahgrdvlayagrrrpgsgtpepgpgqrlve---------lrpsqmsalrtylrltg 74 
WP_100201616  54 VPAEEV--LRANSSRPTtaravritpdglnalawhqgrtdaappcpawtakaadpayreialqpremlllrrythllpgl 131 Streptomyces ca...
KRD18011       4 ANRETRaeLSAWEGRPVrcavrlaaaghdllaydcsrpdpvasqpgpgeglve----------lapsqmaalrvflaltd 73 
KPI23634       1 MDGYEHldLDEIDFAPM--------------------------------------------------------------- 17 

WP_067237649  18 -------------------EATGRRLALLTLEEAHDLLRLLVTLAQESGPVSpEADRLAKEIAARI-------------P 65  Streptomyces lo...
1_pfamImport  79 agapapaetlwealteahfDRDANRWRLQLDETGLAGLAHAVHLEALVGGVT-HRNRLRRAYDLGHph---------piP 148
WP_109378876  18 -------------------DPTAQRLALLTLEEAHDLLRLLLTVAQQEGPMSpEADRLAKEIAARI-------------P 65  Streptomyces sp...
WP_053764138  19 -------------------EHTVERLALLTLEEAHGLLRLLQAVAQQDGPVSpEADRLVREIAARI-------------P 66  Streptomyces
WP_063797295  19 -------------------EHTVECLARLTVEEAHDLLWLLQTMVLQDGQVSaEADRLAREIAAGI-------------P 66  Streptomyces
WP_043447034  18 -------------------ERTTERLALLSRDEAHDLLRLLSTIAEEGGPMSvEAGRLAREIAARI-------------P 65  Streptomyces no...
WP_057578219  18 -------------------EHDVERLRLLTLGEAYDLLHVLRTVAQEGGTVAgEADRLAREIGARI-------------P 65  Streptomyces sp...
KPI22839     126 elksppatglaeqvrtavyDLRTRRWQLRLTQEQMESAAYGFWLHRLTGSAA-EANRFGRDYGVLYs------------P 192
KUN77674      75 glhrrpaeglaeqvdaavfHRAGNRWRLLLTQRQMESAAYGFWLHRVAASAT-EANDFGREYDVTYr------------P 141
WP_100201616 132 aaapaaagtlwealieahlDTAANRWRLQLDGTGLAGLAHAAHLEALAGQVA-PRNRLHRAYDLTHpr---------pvP 201 Streptomyces ca...
KRD18011      74 rlrsrpapglaeqvrgavyDRGVSRWRLHLTQQQMESVAYGFWLHRLTGSAA-EANRFDRDYGVVYa------------P 140
KPI23634      18 -------------------EHDTERLRLLTLDEAHELIQVLRTTTEEGGSAAqEADRLAREIGALIgywprsaqivplrP 78 

WP_067237649  66 SEN 68  Streptomyces longwoodensis
1_pfamImport 149 AAC 151
WP_109378876  66 SEN 68  Streptomyces sp. NWU339
WP_053764138  67 SEN 69  Streptomyces
WP_063797295  67 SEN 69  Streptomyces
WP_043447034  66 SEN 68  Streptomyces nodosus
WP_057578219  66 SAD 68  Streptomyces sp. Root264
KPI22839     193 GSA 195
KUN77674     142 AHG 144
WP_100201616 202 PAP 204 Streptomyces carminius
KRD18011     141 QAQ 143
KPI23634      79 AAV 81
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