Conserved Protein Domain Family
DUF6401
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pfam19939: DUF6401 
Family of unknown function (DUF6401)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001580) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the ebelactone biosynthetic gene cluster from Kitasatospora aburaviensis. This family appears to be predominantly found in actinobacteria.
Links
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Statistics
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PSSM-Id: 498416
Aligned: 59 rows
Threshold Bit Score: 50.4104
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_091556527  35 PVLMTVVTQHTAAVRESVDS-----AGHPVDPDgvdsagrpvdliGLVTYARS--------VVAAAERSGCPlPApgEad 101 Micromonospora ...
WP_054293053  34 PVIAGALDRHIQAVRAQLDRdarlrEGLVTAPPl----------vLLAIYAEE--------IHQEAVKAGWE-PP----- 89  Kibdelosporangi...
WP_245959660  33 PALRRLFDQHLERIADTLRDeerlvDRAVPTTQl----------vLIAGHAYD--------IRRQALREGWQ-PPrtE-- 91  Prauserella fla...
WP_009152167  30 PAVRRQFDRHLEGVVETVAErerdlDRAVPASQl----------vLLASHAYD--------IRSRALREGWQ-PPrtA-- 88  Saccharomonospo...
WP_245992359  15 PALRRQFDQHLDSVVEAIRDgealvERAVPTTQl----------vLIAGYAYD--------IRQQALLAGWE-PPkaE-- 73  Prauserella mur...
WP_017984437  34 PSLWRAFGRHLAAVDDAVRCerdmvPRQEPVSRl----------vLLAGHAHD--------VWTEAAELDWQ-PPadP-- 92  Amycolatopsis m...
WP_092540642  39 PGLLALIDQHAAAVREALRT-----AGRRPDAA------------GLAAYARS--------LAAAAVRSGRPlPEpgAap 93  Actinoplanes de...
WP_091074688 136 PTLAHLLDQAAATLDDRLFGkgrskELPLI---------------RIEAYTNG--------LVDALSEPGRA-PSqhR-- 189 Micromonospora ...
PSK97365      55 PRLTAELDQHAAAVRESIERdgia-----------------lsrrSLTHYLHG--------FLDGCRERGWA-------- 101
WP_111178825  29 PGFSAAISDHVAWIREDLERggprtAGLLSRKT------------TLNAYLLGhahavvdcLVEAAMRPGGEsPAaaDp- 95  Nonomuraea arid...

WP_091556527 102 lscSDWLGAPWPLLRLLGVCALIEETTLPA 131 Micromonospora pattaloongensis
WP_054293053  90 ---IAWTSLDGLSLRLLACCAVAKDRPVAR 116 Kibdelosporangium phytohabitans
WP_245959660  92 ---ADWTTDEWFGLRLLACYELASREPRGP 118 Prauserella flavalba
WP_009152167  89 ---AEWSQDEWYGLRLLACYELASREPKGP 115 Saccharomonospora marina
WP_245992359  74 ---ADWAAGDWYGLRLLACYELASREPKGP 100 Prauserella muralis
WP_017984437  93 ---GDWTDREWTGLRLLACLRLAADEPHGP 119 Amycolatopsis methanolica
WP_092540642  94 asvAGWASAGFPLLRVVAVCLIAVSSNELN 123 Actinoplanes derwentensis
WP_091074688 190 ---YRGYSSD--MILIAALCQLYDRYDEVD 214 Micromonospora nigra
PSK97365     102 ---SDSVEFDWETIRLLAIGRMARESGFVS 128
WP_111178825  96 ---------DFVAVRLGAMFHLAFDGGLLR 116 Nonomuraea aridisoli
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