Conserved Protein Domain Family
WCOB

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pfam19913: WCOB (This model is not part of the current CDD release)
Wolframin C-terminal OB-fold domain
OB fold domain found at the C-terminus of the wolframin protein. Localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. Predicted to mediate protein-protein interactions.
Statistics
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PSSM-Id: 523791
Aligned: 39 rows
Threshold Bit Score: 78.894
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDS38516     763 WNTYEYELKVRMPSLGl----------LSKPSEITLKAQHAFGNFTQSLNNSDRIWFMGILRNflkpaastsssdlhsan 832 
XP_024508652 616 YNVYTYEIEVAGPYGEsk--------iNSNKGSIILTAGDIFGEVLQILEEGDVINFIGYFDQy---------------- 671 
EYC18079     658 HNVYTFDIEVSGPYGErm--------vSSAKGQLILSAGHVFYEMLRLVDEGDVVRFVAFFDQy---------------- 713 
KHN73021     136 HNTYSLEVEVSGPYGEhy--------iSSNKGLLTLSASNAFTEIFKILDEGDLIRFIGYFDHy---------------- 191 
JAJ45513     753 KFTLRIEVESKVPIQLsswfgd---pnsdkTLAVELLAGPRFQKLALRLSSGQEIRFRGTFSSp---------------- 813 
XP_046436815 758 KFTLRLEVESKIPIQLaswsgd---nnddkTLTVELLAGPRFQKLAFRLSPGQEIRFHGTLSSp---------------- 818 
3_pfamImport   1 WNRYTYEIEIKMSNEGvwgnsgdittlLTNSQDIIM------DNATKSLRENDHVWFSGQLSGnk--------------- 59  
XP_973480    717 YNSYTFEITTKVQSAIw-----------GKSPEVTLVVDDYFRNFTLGLKPNDHIWFKGTLFNnevv------------- 772 
ELT98538     672 LNRYQFEMWVTMVIDNd------------nMHDIRVEASHWFKDSMMKIQSGDTVRFRAALKS----------------- 722 
XP_009046104 633 HATYIFTLTVKID-----------------QVNLNIEAGNEFKDIILSLNPAIPVSFNATLNG----------------- 678 
EDS38516     833 lndlhmdlggataggtgtfgsgdrsdrsnmRLGRKNPLVELISVGCINCQNKELRSVH--LSDGL---KVNARMRDLLRG 907 
XP_024508652 672 ------------------------------PVFRYPPKLQLAQLECVTCKQLFKNKQNkrLKITRadsQKRRIWYNILHS 721 
EYC18079     714 ------------------------------PVFRYPPRLKLLQLECANCKQ-FQKGRNshLRVKNskmSRTGLWHQVFEA 762 
KHN73021     192 ------------------------------PIFRYPPKLRLLQLECLTCRQLLNRKDLknLRVVYvrmDRRRFWNRVLFT 241 
JAJ45513     814 ------------------------------SVGGLKPELVLSSLECLSCQSDSSFNGRadSSADQpvhELPDASIFVDKA 863 
XP_046436815 819 ------------------------------SVGGLKPELVLNSLECLTCQPDSTFNSHaeSNSHQpvgDLPDATIFIDRA 868 
3_pfamImport  60 ----------------------------fgILTAKNPFVQASTVGCLTCSKVQVINNNvrQ---------KSFDDELVKC 102 
XP_973480    773 --------------------------gsdgILGGFKTHVKLDEIGCLACSNNKLTNVKkeIESRF---DIKNVIDGLVLG 823 
ELT98538     723 ------------------------------EIGNIWPILKLFYVECENCPMEVIGESSafYQQTGwhiFV-----AIRDA 767 
XP_009046104 679 ------------------------------GLGTGAPSLKLLSLKSLDENLTLMMAVEeeD---------GFYYRAIHEA 719 
EDS38516     908 IKYLLNVIFNPLVIFK 923 
XP_024508652 722 FKFMFNFIFAPTLTMK 737 
EYC18079     763 FKFCFNFMFAPVVRVK 778 
KHN73021     242 FKFLFNFIFAPIFRMP 257 
JAJ45513     864 LQGAADFILPHFLRLN 879 
XP_046436815 869 LQGAVDFVLPHFLRLN 884 
3_pfamImport 103 AKRLFQFILYPIVLFK 118 
XP_973480    824 LKFVLNVILSPVVVFK 839 
ELT98538     768 IRAVWNFFMAPLLVFS 783 
XP_009046104 720 LSFTFNFIWFPIMEYV 735 
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