Conserved Protein Domain Family
DUF6308
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pfam19827: DUF6308 
Family of unknown function (DUF6308)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000699) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the hygromycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. hygroscopicus. This family appears to be predominantly found in Actinobacteria.
Links
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Statistics
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PSSM-Id: 498315
Aligned: 52 rows
Threshold Bit Score: 111.543
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_073889504  18 VAFWIKDYFDETanreaaalgKGPVYAYPAYDRLATGSG-PNELNDGDLLAPLVLNAGPS-IKAVYSLQRVRPALERSLA 95  unclassified St...
WP_239697864   6 AAQWIRQYFDAEanraaavaaKGRPYAFPAYDRMNTGSG-PNELNDGDLLAPVLLNVAPK-LHAVLNLQAVRPDMEAVLA 83  Streptomyces sp...
WP_043123499  16 AKAWATEYL------------TSPRSSYPAYDAYEGSGTdSPLLGDADLLAPALLNVSQNpVPTYYSLKDLTPTLNELLQ 83  Sinomonas humi
WP_009774374  16 AKALVAEYVS-----------KSGGWAYPAYDAY-EGSG-GTTVGDADLLAPLLLNVRNLsLDAYYAMQALLPEINSQLS 82  Janibacter sp. ...
RNL51870      25 ARRMVWEYVS-----------EYGNWSYPAYDGYLRDAP-TTDVRQQDLLAAALLNAGQQpIPTYYGLLKLLPEINRRLA 92 
WP_005270173  17 ATDYVRVYTAN----------TTRTWSYPAYDGY-PGSP-AETVELPDLLAASLLNAGQKpIVSYYAFEELLPEINKRLM 84  Arthrobacter cr...
SDI97154      27 AKEWANTYFVG----------RPGTSAYPAYDEY-PGSP-GESIGKQDLLAVVLLNVSNKpLPVYYGLESLIPFLNERLD 94 
WP_110106309  17 AKAFARKYLS-----------GEGIWAYPAYDAY-PGHP-GTDVGHADLLAVALLNAHQRpLDSYYGLESLIPLINERLS 83  Arthrobacter ps...
WP_036332766  11 ACDHTRQYLT-----------DGSGWGHPAYERYEARRA-LGPLTDADLLAPPLLNVQPFdLGVYESLQAVRPQLQESLD 78  Modestobacter c...
WP_124797905  25 VLTAAREYLAA----------QGGRFGYPAYDAFEAGGG-PGRISDGDFLAPALLNAPVN-IKAFYSLESIRLQLEGWLK 92  Nakamurella ant...

WP_073889504  96 EIPTNLTLHTAVEKGthTKLLGDLVSVLDPfgaLPGVQLTTLVKVLHRKRPLLIPLFDDNVRRcYWtreptagypmTRVr 175 unclassified St...
WP_239697864  84 AIPPRLTLQDAVASGvhTEPLRRIGELLDDpalLRGVGGTILMKIMHRKRPLFLPLYDTQVYAcYCgpga--qypiRKSp 161 Streptomyces sp...
WP_043123499  84 NVPTQLALDEATEDD--LASVAALFGVLDSr--PAFVGMTTLSKVLSRKRPGLIPVFDVAVRHcYTecdga-pvpvEKA- 157 Sinomonas humi
WP_009774374  83 ELA-GMTLLEADDET--LSKLADLLALHETr-qIPGVLLTTFSKVLHRMAPELIPLYDDHIRRcYMelgqp-viptAKKg 157 Janibacter sp. ...
RNL51870      93 DPRLKGTLKEAEDDT--LEAIAELYGILDEh-pQHQVQLTKLSKVLHRKRPELLPLYDENIRRcYFefgdhvrvepVKR- 168
WP_005270173  85 VPELTGTLAEATPAM--LEALADLFGVLDDh-kVKHVGMTKLAKVLHRKRPDLIPLYDENIRRcYSdlgtk-pvpvVKR- 159 Arthrobacter cr...
SDI97154      95 DPAIHGDLASASTET--INAIVHLLNVIEEr-pTDHVQLTTLSKVLHRKRSALIPLFDDNIAYcYSkcdga-pvpyVKKg 170
WP_110106309  84 DPALQGSLAEANAAT--LDAIARLFGVLDEk-rPKYVSLTKLSKVLHRKRPELIPLYDKNISRcYAdegl---dprDRS- 156 Arthrobacter ps...
WP_036332766  79 QIRPAASVFDATDNE--REHVRRMFALIDRr-gIPGAKGTILSKVLHRKRPDLIPLWDGNVEKvYQygetp-rippVNG- 153 Modestobacter c...
WP_124797905  93 KVPVDARLVDAGSDG--LALLGELFSVLDAkprLPHARGSVLAKVMHRKRPAFVPLYDRYVDFcYRgsena-pisvDRG- 168 Nakamurella ant...

WP_073889504 176 nRRDAEFFPLLAGFIDADLERQWEDWAVLASHAPAd---TTLLRVFDVVAWRLG 226 unclassified Streptomyces
WP_239697864 162 qRTWAEFFPLLGDAMARDLDGQPHTWKALVSWAPDd---VSVLRVLDVVAWNLG 212 Streptomyces sp. F-1
WP_043123499 158 -RSWEGYARAWLDAVRDDLVRHHREWEALAALAPEdqmpISPLRALDIVAWRAG 210 Sinomonas humi
WP_009774374 158 tRNWTEFTILWLRAVQADLRVHHDEWRELAGLAEHp--tITPLRALDMIGWRLG 209 Janibacter sp. HTCC2649
RNL51870     169 -RKDKDRMLVWLPEVRKDLRIGVQEWNALAALAVEp--pISPLRALDILGWRLV 219
WP_005270173 160 -RTRRDFCRAWLPVLRDDLVSQQESWQQLADLATEp--kISPLRAMDMVGWKLG 210 Arthrobacter crystallopoietes
SDI97154     171 tRNRAEYRRLWLEALQRDLAGQFSLWEELAATAPGp--sVTPLRALDIIGWELG 222
WP_110106309 157 -RSWHDYSRLLLAAMKRDLADQIDHWLEIADLATQv--kITPLRAMDIVGWHLG 207 Arthrobacter psychrochitiniphilus
WP_036332766 154 -RSWGEFHLVFSDAVRADIEADPGFFEDVAALAVDp--pISLLRAVDVVAWWAG 204 Modestobacter caceresii
WP_124797905 169 -RTWQQFAPLLGQAMINDLQRERDFLAEVVALAQGp--vITPLRALDILAWQAG 219 Nakamurella antarctica
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