Conserved Protein Domain Family
DUF6301
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pfam19818: DUF6301 
Family of unknown function (DUF6301)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001381) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the brasilinolide A biosynthetic gene cluster from Nocardia terpenica . This family appears to be predominantly found in actinobacteria.
Links
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Statistics
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PSSM-Id: 498306
Aligned: 48 rows
Threshold Bit Score: 72.3944
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
RDI65735      57 VRTATEFDWTWTAADLPAFS-DLVGWQLTGL-DQTYPELTTDL---DVNRRDTMLsvdntvgtGDsrpLNHIWFRTTDVI 131
WP_035904804  16 LTFWLDAPWPLSQLEAASHA-SALGWTVQRDdDGKPWVI-------APDRPFESRavig-lrsEPr-pTATMDWDLTDLA 85  Knoellia subter...
WP_104482486  15 LDFWAGLPWPLSRADAQRRAvDRPGWAIEVE-DGLGYLVNPALtppAVSMPGIDT-------------VSSVRFRITDAV 80  Actinokineospor...
WP_015102535  15 VDFWAGVPWPVTRAEAHLLAiDRFGWEVEVE-NGREYLVNSVA---GLTPPDVST--------VDaetLMSLDFWIADMI 82  Saccharothrix e...
WP_124933097  16 IQAWTDHAWPMSLQEAFAIR-DSLGWMPSHQ---EPRYFTTKL---ST-NGKEDGmilr-sneFG---IKGVNFKLSTTP 83  Actinomyces bow...
WP_124933095  16 IRAWTDHAWPITLQQAFAIR-DRLEWVPSPH---EPRFFTTKL---SL-NRRENGrisr-sneFG---ITGVNFSLSSTP 83  Actinomyces bow...
WP_124933096  16 IRAWTDHTWPITLQEALAIR-DDLGWKPLPE---DDHYFATEL---SV-EGNWGGrisr-sneLG---IKGVSFDLSAPP 83  Actinomyces bow...
WP_124933101  16 IRAWTDHTWPMSIQEAFTIR-DNLGWKPLPN---EPDFFTTPL---SR-NGHWGGyilq-skdVE---IKGVSFDLSSPP 83  Actinomyces bow...
RTE48626      23 IRLWLEHDWPLSTDHALQLR-DELGWVSSPS---KATLFTTN----HG-TGEKDAsaia-irgM----VDSFAFNLSSRI 88 
EGQ74846      34 IRAWAEHPWPMSPAQALALR-DRLGWTSSPT---KEWMFTTD----HD-LEEKDAsftt-ikrEQt--VASFNMSLTSRI 101

RDI65735     132 ----LDDTNLKPEIDRVFDELAQRVFEVLGRrADEW--WVEPTRGLRWHLPT-IAVAVTTSARTVYVELVSPEY 198
WP_035904804  86 p---LDDLQAEDEVRDLFAEYVAAGRGLWGRgv----mRRKYDPEVSWDLGDrGGIQMRGG-MSVRVSFVSPDH 151 Knoellia subterranea
WP_104482486  81 t---KETPASRAFLGDLFTLVVRQGADRLGR-PSIR--RDRGHTDATWETGP-AQITVTLSSRSVMVRFRTPEG 147 Actinokineospora aura...
WP_015102535  83 r---EESAQSRALLGDLFTLTVREGVSRHGR-PSLE--RVRSGTDATWSLAGnCQVTVSLATKSTRVEFHTPQL 150 Saccharothrix espanae...
WP_124933097  84 c--pEENEQTTQMSITAYSQYATALEQLWGP-GQpg-kGPYASSQLRWTLPNkVSISIILTAPLIGIDIDSPWR 153 Actinomyces bowdenii
WP_124933095  84 s---SEEIEQKKIAHAAYSHYINALQSLWGP-G-----TTYGKSHFRWVLSNkVSISIILTGTRIGVKIESPWL 148 Actinomyces bowdenii
WP_124933096  84 s--cELDEQNFQASRRAYSQYVTELKKLWGS-GRpg-kNDFNSPQHHWKLPNkVSISITLTEPLIGIDIDSPWR 153 Actinomyces bowdenii
WP_124933101  84 smspEMDESGMQSAEEALFLYASPLKQLWGP-GKmr-tSTQKTTHLRWTLPNkVSTSLIRANVLINVTIDSPWR 155 Actinomyces bowdenii
RTE48626      89 a--lEFEPLVEAVARSAFDQYVGALSAFYGK-GITEwnDEGEARSVTWQLPStATVQIGKSGWLLRVNIDSPNA 159
EGQ74846     102 p--kDVMDEAVPITKRAFDAYVEALTAVYGQ-GKRG--KRKQHASVTWTLPSdASVRIGTVGWVIGADVDSPAG 170
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