Conserved Protein Domain Family
DUF6300
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pfam19817: DUF6300 
Family of unknown function (DUF6300)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0002024) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular, the nargenicin biosynthetic gene cluster from Nocardia argentinensis. This family appears to be predominantly found in bacteria and unclassified phages.
Links
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Statistics
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PSSM-Id: 498305
Aligned: 13 rows
Threshold Bit Score: 89.089
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9ACS9         6 EINFRFDqv--pPCARCGGEALLRVRFGHSWTNITGH----LVEGFREADLCPACDS---GTTPADDLLALFAVAERVPP 76  Streptomyces co...
WP_093942924   6 EVDPTRD-----TCHRCGGPLLLSVRIPHSITGRGGGgerfEVRGRRTVPLCARCDR---DDPGAMGVIAFFTVHETISD 77  Actinoalloteich...
WP_035284022   9 EVDLVAGl----RCHRCTGEVVCAVRVPHSFLRADGT----EVGGTRLVALCPDCDR---GRAGAAPVIAYFRAHGRVVA 77  Actinokineospor...
WP_071369455  10 EALLKLEdt--pSCPHCGGPTLLLARYPQAWKSARGE----DVSGIKEAVLCAACDH---VDAAAAELIALFNLDEQVSP 80  Streptomyces co...
WP_100596290   9 DVIIQLDdm--dACRACGEQSVLKASFTQTWTNKRGE----AMSGLCEAVLCPECER---GTPAADELLALFAVDETLGI 79  unclassified St...
WP_069931054  30 YPDRDEDeqparPCSRCEGELLLHWHGPL----ITGV----------WMELCPACDT---RRPAARAFLQWH----RDPD 88  Streptomyces ag...
WP_108154079   2 DRVELAEtl--pSCSRCGGSLTTSGVMPHEDASGFPI----------HLELCSSCDT---DKPAAGALLRWFATGGGHDM 66  Streptomyces lu...
WP_071279890   4 VSVRRSNdl--pACSRCNGPLILAAQMPQLDASGNPI----------TLELCAACDA---GDTAAGVLVRFFTSGAANDT 68  Streptomyces sp...
Q82QP4        11 YRLETSGll--pQCSRCGGDLIVSVVAPKNDTDGRPI----------QLQLCSACDA---EKPAAGALLFWFASGGGHDT 75  Streptomyces av...
WP_007505418   2 ALLEFSDrl--pQCSRCRGSLIMSGVAPQDDKHGRPI----------HLELCPVCDTgdvDRPAAGLLVQWFADGGSHDE 69  Streptomyces zi...
Q82YG8         2 ELLRFSDrl--pQCSRCRGDLIMSGVAPQNDKHGRPI----------HLELCPVCDTgdvDRPAAGLLVQWFADRGGHDE 69  Streptomyces av...
WP_103956359   5 IEVVTEAap--pDCPRCGGASLLWARVPHGWENATGG----RVEGYSGVVLCGSCDA---DRPHAAALITWFHVHGRADD 75  Nonomuraea solani
WP_111176107   6 IDIVSGQep--pTCPRCRQEGLLLARVPYGWTNEGGV----AVEGRNGVVLCAACDT---DTPYAAQLITWFHVHGTVEA 76  Nonomuraea arid...

Q9ACS9        77 THLAEFGCRVVAWVESVRQPrvdmvrlrgEEDAHR-HNGEL 116 Streptomyces coelicolor
WP_093942924  78 ETVQAAAPVLRQWIDEAVANppvytdadlDAEIDAwEAGET 118 Actinoalloteichus hoggarensis
WP_035284022  78 DRVEELAGLLREWVADVGPA----------------RAGDL 102 Actinokineospora spheciospongiae
WP_071369455  81 E-METFGGLAAAWVESVRQRtvde--tllQEQHELwRCGEL 118 Streptomyces colonosanans
WP_100596290  80 NNIETFGGLVAAWVESVRHQrvde--arlTEEHEQw-SGEL 117 unclassified Streptomyces
WP_069931054  89 RDPKALPKLFEDWETE-------------TMHAHGwARAPQ 116 Streptomyces agglomeratus
WP_108154079  67 ARVHEGADLMTEWTKE-------------AMAEQGwIWSDH 94  Streptomyces lunaelactis
WP_071279890  69 SRAHEGAELLLAFQKE-------------IMAAHGyVLVDN 96  Streptomyces sp. CC53
Q82QP4        76 ERSEEGARLLMEWTGE-------------AMAEYGwYWPGT 103 Streptomyces avermitilis
WP_007505418  70 SRIKEGSHLLMEWTKE-------------CMAIHGwYLQDA 97  Streptomyces zinciresistens
Q82YG8        70 SRVQEGSHLLMEWTRE-------------CMAVHGwYLQDT 97  Streptomyces avermitilis
WP_103956359  76 TD-EEFVRLLVAWTAGVVIPalde--ralKDEVERwTLGER 113 Nonomuraea solani
WP_111176107  77 GHSEEFLRLLAEWAEQISVPpldr--qrlETEIEQwRRGRA 115 Nonomuraea aridisoli
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