Conserved Protein Domain Family
DUF6247

?
pfam19760: DUF6247 
Family of unknown function (DUF6247)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000345) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus. This family appears to be predominantly found in Actinobacteria.
Statistics
?
PSSM-Id: 498256
Aligned: 47 rows
Threshold Bit Score: 42.7145
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WP_091810675          8 PPFALSGLSP---RAIRDAVLEEERA-----GFERQFRAALDVAGETLDLTGVETVLRAWQRIGELteRDGREKRREVLA 79  Prausere...
WP_012918317          9 PGD-----DP---AEILRVLPAKWHE-----QFLSEYHQALDAAHEVWRFRQLRDVLHLWQLRAVA--YSNPDFDKAAAA 73  Kribbell...
WP_026404311          9 GPL-----DP---EEILRRLPHEERD-----RFVHEYRSALDAAHEIWRFRQLQEVLRLWHLRAVA--YAQPDFKERAEQ 73  Actinoma...
WP_116021519          9 GGP-----NP---EDIMRRLPADERD-----RFERDYHDAVDAAHEPGRYGHLQDVVRRWHLRAEA--HTHPDFT----- 68  Thermomo...
WP_125643468         11 P------PAPaaaAQLLARLRAGRRAetwvpAFQQDWARALDASRHTYTLTPLHDVVRTWQ--LRV--AAIPAVDGF--- 77  Streptom...
zhongguo:SMD11_0415   5 P------PAPaaaARLLARIRAHGRAaqwepAFERDWGKALEDSRATYTLTPLHEVVRTWQ--ARL--DTAPAVGAF--- 71 
WP_110673597         12 PPA----PAPaaaARLLARIRADHRAdrwqpAFERDWAKALEDSRQTYDLTPLHEVVRTWQ--ARL--DTTAGVDAF--- 80  Streptom...
WP_093782138         14 P------PAPaaaARLLEALRADRRAgrwvpAFEADWARALEDSRHSYSLSPLHDVVRTWQ--ARL--AATPAVDAF--- 80  Actinaci...
WP_053678036         12 PPA----PAPaaaAELLGRIRADRNAerwepAFERDWAQALEYARHSYSLAPLHDVVRTWQ--VRL--TAAPAVDAF--- 80  unclassi...
WP_126917706         12 PSVPPPAPAPaaaVRLLARIRADRRAerwvpAFEQDWAKALEDARYSYSLTPVHDVVRAWQ--ARL--AVTPAVDAF--- 84  Streptom...
WP_091810675         80 ravrvwrnrdnpdperdrqsrefeerlwarlseeqrqrvlahreqvrrqvevgepvtdsqgrpMgESEPyvlvPLDElSF 159 Prausere...
WP_012918317         74 ---------------------------------------------------------------ArQGCDs--------EF 82  Kribbell...
WP_026404311         74 ---------------------------------------------------------------ArAGTG---------DF 81  Actinoma...
WP_116021519         69 ---------------------------------------------------------------ArPGTGdp------aTF 79  Thermomo...
WP_125643468         78 ---------------------------------------------------------------LaSGHD----ETGSvDL 90  Streptom...
zhongguo:SMD11_0415  72 ---------------------------------------------------------------IdAGLD----DADGvDL 84 
WP_110673597         81 ---------------------------------------------------------------AaGGLD----DEDGmDL 93  Streptom...
WP_093782138         81 ---------------------------------------------------------------IaSGYD----DSDGvAL 93  Actinaci...
WP_053678036         81 ---------------------------------------------------------------QaSDRD----DTDGtAL 93  unclassi...
WP_126917706         85 ---------------------------------------------------------------LaAGMD----DSDGvAS 97  Streptom...
WP_091810675        160 DDDAEiaaeRP 170 Prauserella marina
WP_012918317         83 VPADQvlpdWP 93  Kribbella flavida
WP_026404311         82 ISADEafpeWA 92  Actinomadura
WP_116021519         80 IQDLDeipgWP 90  Thermomonospora umbrina
WP_125643468         91 DEV-------L 94  Streptomyces sp. WAC06614
zhongguo:SMD11_0415  85 DQV-------L 88 
WP_110673597         94 DQV-------L 97  Streptomyces tateyamensis
WP_093782138         94 EDV-------L 97  Actinacidiphila guanduensis
WP_053678036         94 EDL-------F 97  unclassified Streptomyces
WP_126917706         98 EDA-------L 101 Streptomyces luteoverticillatus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap