Conserved Protein Domain Family
DUF6242
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pfam19755: DUF6242 (This model is not part of the current CDD release)
Domain of unknown function (DUF6242)
This presumed domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 290 amino acids in length. It contains a BNR/Asp box motif at the C-terminal, which contains the characteristic sequence motif SxDxGxT/xW of the BNR family, present as repeats in sialidases and others glycosyl hydrolases.
Links
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Statistics
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PSSM-Id: 523763
Aligned: 127 rows
Threshold Bit Score: 77.5103
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDC24550      36 DTAITDFSLGKMDKfgKKkdgvsdsllrgvvDGSTFGFTIDQANHE--IYNLDSLPVNTRIAAVLATIS--AKNS--SYI 109
WP_036848328  46 NIQIKENDV-----------------------FSQTKFTIDHFNRK--IYNSVRLPYKTELDTVFLRMMisSETKv---- 96  Porphyromonas s...
WP_070707867  62 KDKDKKEEVK---------------------GLPNLDFNIDNRAMR--VWNKIPLPYQSKFDSLDLTIAvtSEAVv---- 114 Porphyromonas s...
WP_148130688  47 VLSFPKVKGK---------------------QIPAARFSIDHINHR--IYNKTPLPYGSEIDSAYLSMAvsNQLKv---- 99  Porphyromonas s...
WP_036850619  46 SIRFPKGS-----------------------KLPTETYNIDNIRKL--IYNERPYPYQSKFDSAYLNMAvsTESKv---- 96  Porphyromonas c...
WP_036873951  32 NIELGGVQIGHLRLknKKi-----------pELEKVFFSINQKTGE--IYNAIPISFYTKMDSVAISLElfEKAF---AE 95  Porphyromonas m...
WP_023939785  30 DSAVEKVDLTSVQIhtLVmqsk------dtpELGKVFFSIDQRQGK--IYNAIPIAYKTRIGKVLPSVGtfKLNKlsYAV 101 Porphyromonas c...
Q7MXJ6        40 DLQIHRFYLSTKKNp----------------DLEKVFFSIDHAKGT--IVNKKYMPYGTVLDSVLMNLVtdLSAK----- 96  Porphyromonas g...
WP_004333587  38 TVQVSSFVLTSKSNp----------------TLEKVFFSIDHAKGK--IYNAQPLPYGTQIDSVKIKVGiqTPATfkLLI 99  Porphyromonas e...
WP_044168007  39 NGQIRTFSLSSEDKaaKA-------------ALERVTFSIRN-SEEglITNPSPLPFAQPLNKVKLNIVafNA------- 97  Porphyromonas c...

CDC24550     110 -QinyvkqvpVKEGettDS-IVWYNST-ES--ID--------FTKt------------kEKAIRVY--------AQ---D 153
WP_036848328  97 ----------EIKNlttNEtFPWTVEKmNSksVK--------VK---------------GGKLELL--------LSaniN 135 Porphyromonas s...
WP_070707867 115 ----------KIINettQKvTVYASNR-RAqrID--------AT---------------GGKLKLT--------VE---I 149 Porphyromonas s...
WP_148130688 100 ----------TLRNvssDKrVAWNVAGsDTtlIS--------FK---------------GGRMELT--------IQtdkK 138 Porphyromonas s...
WP_036850619  97 ----------RITNeltKKsIDWSVR--DTgkID--------VS---------------GGKLLVE--------VS---R 130 Porphyromonas c...
WP_036873951  96 iAkensneykRLRNdgkDSiWLGGT---DR-----------------------------VFNLRI---------SM---P 131 Porphyromonas m...
WP_023939785 102 gDnaewvpwsGK----------------DSiaLN--------GAD--------------RIRFQVK--------DQ---A 132 Porphyromonas c...
Q7MXJ6        97 ----------KLQVavnDGeYKDWHNK-DSlwLRdc----------------------hTLHLMVF--------DE---S 132 Porphyromonas g...
WP_004333587 100 ----------------------------DGkeIErsaadsiyLRDrw----------nkEITVEVT--------NK---E 130 Porphyromonas e...
WP_044168007  98 ----------------------------DGtkIDvavgtngaFEEwkaskvydlssgvsELRVRVRnkvtnpqlGS---- 145 Porphyromonas c...

CDC24550     154 A-SaYADYKVKVNVHTQRPDTFIWQSL-TqAnaklA-----ALNSMKAVS----A-----GG----KVVLFGkNAE---- 209
WP_036848328 136 GvNkTEKYLMNINVYSYDPNVITWEKK--------EnvlpvAAADSKFITlnktLywvalDKhakfHLYEVLsVESyn-- 205 Porphyromonas s...
WP_070707867 150 EkKpTLTYDLRILTYGYDPDKFTWTKE--------SaslpiAAVDAKVLKyqnrIfwvasLSdgssKLYEYElTNSkf-- 219 Porphyromonas s...
WP_148130688 139 KdNqSVTYDFRVLTYGYDPNKIVWTDM--------SnglpiETEETRMVVlpgdRryllsRLgretSLLEITtLDPld-- 208 Porphyromonas s...
WP_036850619 131 KgYnPIVYKMRLQIYGYNPDKLTWKKV--------AsglpiASEDGHIFSiegeKcwmtrLGkk-vNLYQVKdLDKgefl 201 Porphyromonas c...
WP_036873951 132 GvDeKKEYRLRINQYQYDPQTLLWERLf-------EsgmpeTSGSYHTVInf---------------------------- 176 Porphyromonas m...
WP_023939785 133 G-KmTKEYQVEIRIYSFDPRTILWEDLg-------TsslsvNLASSYYAI----------QEksdvRIYTNEa------- 187 Porphyromonas c...
Q7MXJ6       133 G-EkTKKYTVTLNRYDYQPTTFVWHMLdG------ValpdiNASFVDVVTha-------------dRVYLVAaTGN---- 188 Porphyromonas g...
WP_004333587 131 K-AlKKSYTVQILKEINNPDSYYWMPV--------IagklpDLSGKETIF-----------CrsdkDLYIFAsQGA---- 186 Porphyromonas e...
WP_044168007 146 --GnEYIYRVHLSKYTNDPQTFSWQRLaSpT-----------------------------------NLPAITsAFTeriv 188 Porphyromonas c...

CDC24550     210 ---GALEMFK-----------SENGKQW---EKISTtanlGNHA-VDNI-VAFD----------------N-ALYVL--- 250
WP_036848328 206 -frKVEGTGDmpailphtltqDTHGRVWgm-------------------------------------------------- 234 Porphyromonas s...
WP_070707867 220 --pEVEGADIpaqllpssivtDGKKQVWai-------------------------------------------------- 247 Porphyromonas s...
WP_148130688 209 -irQVTEAHLpeglrpytaytSPKGDTWal-------------------------------------------------- 237 Porphyromonas s...
WP_036850619 202 lmrGV----YpeglrpktlvkDKQGKFWal-------------------------------------------------- 227 Porphyromonas c...
WP_036873951 177 --kEQLLYYLstdrtklfvadYKDPGKW------------------------QQrplqgftgvmcqvsemQgSFFAVn-- 228 Porphyromonas m...
WP_023939785 188 ---DKVVMYSg---------nLGNPKDW------------------KRQeMSLSgqvvam-----qlnsqGtQRFIQtsd 232 Porphyromonas c...
Q7MXJ6       189 ----KTLLYSs---------dRKNPVHW------------------TLLsSSGLsgacrq-----iaateDgRAWILt-- 230 Porphyromonas g...
WP_004333587 187 ----QTQLYHa----------pANTLVW------------------EEVpTGLSgkpvts-----aiatsEgVLYAIlgt 229 Porphyromonas e...
WP_044168007 189 egtTTDCYFVtsagtnalhsfTATPTSWtvgVFSGI----PSGErLTSVaRM------------------GnTRYATt-- 244 Porphyromonas c...

CDC24550     251 ---NpeTHQL-LK-STD-AANW 266
WP_036848328 235 ----akDGEI-YS-SSD-LKIW 249 Porphyromonas sp. COT-108 OH1349
WP_070707867 248 ----skDQKL-YS-SKD-LKTW 262 Porphyromonas sp. HMSC077F02
WP_148130688 238 ----daEGHL-FT-STD-LVTW 252 Porphyromonas sp. HMSC065F10
WP_036850619 228 ----ddEGFLhY--AENsIANW 243 Porphyromonas cangingivalis
WP_036873951 229 -----tDGKL-FK-SND-GVAW 242 Porphyromonas macacae
WP_023939785 233 gerD----RL-YK-SSD-GILW 247 Porphyromonas crevioricanis
Q7MXJ6       231 ------DSGI-YQ-SDD-FTNW 243 Porphyromonas gingivalis
WP_004333587 230 aptQ----TC-IV-SLDgGKQW 245 Porphyromonas endodontalis
WP_044168007 245 -----sAGKL-YQtMST---TW 257 Porphyromonas catoniae
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