Conserved Protein Domain Family
DUF6236
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pfam19749: DUF6236 
Family of unknown function (DUF6236)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001432) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the myxochromide D biosynthetic gene cluster from Stigmatella erecta.
Links
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Statistics
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PSSM-Id: 498245
Aligned: 5 rows
Threshold Bit Score: 259.604
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_043507524  35 PEGYRLSDSRTArvlaeeldfVRDVGPTTTARQVAPMFfdlldrHAD----ALRAAGYGVSESWEERNIHAA-------- 102 Streptomyces gl...
WP_245686482   5 ICGNLLSSSSLV---------ARDVTGTVTTRTEQPVV------NGP----AIHQLGFEKSDLASGARALIVp------- 58  Paracoccus tibe...
WP_085212025  34 PRGFPVVDHETVtalhseldfLVDVDPQEAAAAVAPRFlrvlgdHGA----ELRAryLADAARGMQTNSSHEpppvggdf 109 Streptomyces sp...
PNH90273       2 LKGIIAAPANVT--------------------GNGSQFsssqglTAE----DIRYf------------------------ 33 
WP_058380626   1 MRGIVVSPEIVM-----------------SGKNSMSVn------GGTiapiKLRQy------------------------ 33  Planococcus rif...

WP_043507524 103 -TTSFNPTS-------PRSLMPLSGnsrstglRQAGAAASYREEFTPE----------------LREALLATGLAtdIRR 158 Streptomyces gl...
WP_245686482  59 pMMTIDPAKgslrmgdFSAQGIRAG-------LLMWDAFDFPMNTSIN----------------LESVIPDQLVAlgVAR 115 Paracoccus tibe...
WP_085212025 110 pVVTVEPTSetdhltlPTALRPLAG--------------LYWDEVEPG----------------LRNALFDSGLA--VAT 157 Streptomyces sp...
PNH90273      34 --------------------------------LLYWDKVVIPTTNIIHla------------lpDEEDFLSTNI---VTR 66 
WP_058380626  34 --------------------------------LLYWDQIDFPTSNIITfggtadtdflestgalKRS------------R 69  Planococcus rif...

WP_043507524 159 TpgiwarrsladgRWVTMNAALAWVYKCAFVEALAAQGRYTPTTdqPDAHLASDGWDadriaeVLLREpapslspllsas 238 Streptomyces gl...
WP_245686482 116 K------------TTVESNGQIGMGLAEAYATLFRAYEEQHPNT--WSLLSGPDGID------VLGGG------------ 163 Paracoccus tibe...
WP_085212025 158 Trsrla--dslflRWVATDPTLAWVYKCALTEELARRTRYAPTTdqVAAHSATDGWDtdriaeALLDRqtpvv----dsd 231 Streptomyces sp...
PNH90273      67 Prtt------fsgNFNGETMAQAQVVAQTRVANDLITNDQ---TmdWTLHQIGENIIipdreaI---------------- 121
WP_058380626  70 Vnlq------magEFTN-------LFLKSQMEAFRLNNEKEVGS--WSLAQPHYNLVldevsgIMSRN------------ 122 Planococcus rif...

WP_043507524 239 sADIVGLLAIRIAVPADLTDVPVEKIVTLRKNHRDEFAAftsavsetvdqLQQELAGT--TLPEARERYLHMAVE-QRFE 315 Streptomyces gl...
WP_245686482 164 -RNQTGMINFTSCIPIPSAEVPFEEILHFKERRKDEMLA-----------LRQHIEDMilRIQEAGDGELLIDAEvESFR 231 Paracoccus tibe...
WP_085212025 232 fARHIGLMALEFVLPANLDDVPVEKIINLRKRYEAEFTAfnsavstaasdLEAELADI--EDAQALREHLKVDFE-RRFK 308 Streptomyces sp...
PNH90273     122 -QKQIIRVELQNCLPVPYGNVPAHEILEFKERRKDQLQE-----------LHKHIEDLylEVLSSPDPSLKTKRIvTDLK 189
WP_058380626 123 -----IEVELYQSLPVPEKDVPLVDILEFKEKRKDELLE-----------FRSLIDNLylDIVNSGDQERDKLKSlELLA 186 Planococcus rif...

WP_043507524 316 APLQALKAAMKGQGISTAYSAVNVKFEIp---------------aLAAAVGGAGALAGHPLLGGAV-------------- 366 Streptomyces gl...
WP_245686482 232 KAAEDHLKAAKDSGLHFKLGDLSGSFNI-----------------LAPITGGAAAYLQGLSISGAL-------------- 280 Paracoccus tibe...
WP_085212025 309 TPLGDLRKAMNGLHLKTATGIMNYKFELgsl------------ttLLATVAGQGPVTAAGVAPGAA-------------- 362 Streptomyces sp...
PNH90273     190 SSISTVDKVTSENWKATKKFNISAELNLn------------------------GKDIAAGAASGAVfdffqnmftlpigt 245
WP_058380626 187 RKTKEIDRLMEESFMSRLAQSLKIEFDWkdmaaktgttvlgsftgQYTFETGLAVGLLSSINVSSE-------------- 252 Planococcus rif...

WP_043507524 367 GA--ALTFANLRHTHVQQTKAlkAQNPAAYLLAIQRGLT 403 Streptomyces glaucescens
WP_245686482 281 IAgaAAAISFAPSTSVSYKRV--GSTPLRYISRAHSELP 317 Paracoccus tibetensis
WP_085212025 363 TMrqATA--------EARDTQl-RNSPVGYLLRIERNLQ 392 Streptomyces sp. Amel2xC10
PNH90273     246 IVgaLAPIVKINAKYDMSLEAakNKNVLGYLASAQNESI 284
WP_058380626 253 MS---------LKPRSLPPEL----KDYAYLYYSQKEFK 278 Planococcus rifietoensis
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