Conserved Protein Domain Family
DUF6227
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pfam19738: DUF6227 (This model is not part of the current CDD release)
Family of unknown function (DUF6227)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000118) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the pactamycin biosynthetic gene cluster from Streptomyces pactum . This family appears to be predominantly found in Actinobacteria.
Links
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Statistics
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PSSM-Id: 523756
Aligned: 36 rows
Threshold Bit Score: 273.849
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_040022251   1 MN--DPYETTEAHTKRLLGRALNSFDLPDTLVERLDSALAHASSLCSAHHS--AG-----LHREMYRHTYLFTDGGTLTL 71  Streptomyces sp...
WP_234386465   2 VPneCEYETAEEHVTGLLGRALNSFDLPDELVESLGSALAHTTSLHSSLHAs-GGpgrprLSRETFRHTYLLLDGATVTL 80  Streptomyces sp...
2_pfamImport   1 MS--DPYETTEQHLERLLRCALNSFDLSDTTIERLGTALTHSSSLHSSHHS--SA-----LHRETYRHTYLLADGSTLTL 71 
WP_008743012   1 MS--DPYETTGAHLDRLLGRALNSYDLTDRLVERLGTALAHSSSLYTTHHSpaAG-----LWRETHRHTYLLADGGAVSL 73  Streptomyces sp...
WP_069920652   1 MS--DPYETTEAHLGRLLGRALTSFDLPDRLVERLGTALAHSSSLYTTHHSpaTG-----AWRETHQHTYLLADGGSVSL 73  Streptomyces su...
WP_053679640   1 MS--DPYETTEAHLDRLLGRALNSFDLPDLLVERLGTALAHSSSLSTTHHSpsAG-----LWRETHWHTYLLADGGSEAL 73  Streptomyces sp...
WP_112450821   1 MS--DPYETTEAHLERLLGRALNSFDLPDRLVERLRTALAHSSSLFTTRHGpaSG-----RWRETRRHTYLLADGGSVAL 73  unclassified St...
RSS78206       1 MDptDPYETTEAQLGRLLGRALNSFDLPDRLVERLGTALAHSSSLCTTQHRpaSG-----AWRETHRHTYLLADGSSASL 75 
WP_045321468   1 MS--DPYETTEAHLDRLLGRALNSFDLPDRLVERLATALAHSSSLCTTHHNpaAG-----VWRETRRHTYLLADGGSVSL 73  Streptomyces sp...
WP_030238859   1 MS--DPYETTEAHLDRLLGRALNSFDLPDALVERLGTALAHSSSLYTTHHSpsAG-----LWRETHRHTYLLPDGTAVSL 73  Streptomyces la...

WP_040022251  72 WELVHNTGRDGAQ--LHELYADEAEAQLAVSRLyhpdglqaprlgagseisgpfdvpghfdlsepldapeargaygapwl 149 Streptomyces sp...
WP_234386465  81 WEVTHGRG--------NEVYADEESALVAAARLrervlpdlapgfaaddldpg--------------------------- 125 Streptomyces sp...
2_pfamImport  72 WELVHGGGRDTDAprRHELYDDEGDAQVAAARLsgsfwdtraitdessr------------------------------- 120
WP_008743012  74 WELVYRLEGDRAV--RHEVFTGKAEAHLAVARLfgepvsasasevpddlasmaa-------------------------- 125 Streptomyces sp...
WP_069920652  74 WELVYRQEGDRTV--RHELFASKAETCLAVARLfgespseaaldpallpgd----------------------------- 122 Streptomyces su...
WP_053679640  74 WELAYRQEGDRAV--RHEVFASKSDLCMAVTRLfgevparvardlaaspsg----------------------------- 122 Streptomyces sp...
WP_112450821  74 WELAHRGEDDLSI--RHEVFASRAETCLAVARLfgetpsqvardlteatae----------------------------- 122 unclassified St...
RSS78206      76 WELAYRQPGDRAT--RHELFAGRDAACLAAARLfgeepvevpghvgaede------------------------------ 123
WP_045321468  74 WELSYRLEGDRAE--RHEVFAGKGEMCLAVARLfgeaaaeaapgppplpgg----------------------------- 122 Streptomyces sp...
WP_030238859  74 WELAYRLKGDRST--RCEVYPDKDGLRLAVARVfgetpsdgalsplgeged----------------------------- 122 Streptomyces la...

WP_040022251 150 aaqppvspsgpfagpfpspsfddltaglmseleagrgsdiesdftlfssllaappaPLPKTRMYVPDNSADHARRVLRRA 229 Streptomyces sp...
WP_234386465 126 ------------------------------------------lsdlevlsglapveragtgrTYEADDSADHARRLLRRA 163 Streptomyces sp...
2_pfamImport 121 -----------------------------------------ddleiltlltavppaPLP--RMYAPDNSADHARRVLRRA 157
WP_008743012 126 ------------------------------------eeasaaqdaaalsalfttpgPAERQRDYAVDDSADHARRVLRRA 169 Streptomyces sp...
WP_069920652 123 --------------------------------------eeadadvaaltarfaasvSTRPRREYAVEESADHARRVLRRA 164 Streptomyces su...
WP_053679640 123 --------------------------------------ggpagdvaslgalfaappPALRHREYTVEQSADHARRVLRRA 164 Streptomyces sp...
WP_112450821 123 --------------------------------------eepasdiavlsalfsnptPAQRHRDYTVEDSADHARRVLRRA 164 unclassified St...
RSS78206     124 ----------------------------------------pvgdaralsalltaptPVHRHRSYAVEQSADHARRVLRRA 163
WP_045321468 123 ---------------------------------------eehdgpgafgalftakgPSARYREYAVQESADHARRVLRRA 163 Streptomyces sp...
WP_030238859 123 --------------------------------------edgterdlallgslfaasPQERHREYTVEQSADHARRVLRRA 164 Streptomyces la...

WP_040022251 230 ENADRPGEETARLLRTAFAHHITQVFG-RQCQveGKDAGFMLYEHAFLLIDGTETSVWEVEHTATPDGRHMCEMYESERA 308 Streptomyces sp...
WP_234386465 164 ENPDRPGASVARLLRGALAHRITRALG-GHGGaaGR-GGVILYEHAFLLLDGVELSLWEVEHTATPDGSHMCEVYAAEQS 241 Streptomyces sp...
2_pfamImport 158 ENGDRPGAETAGLLRAAFAHHITQIFG-RQCRvdGRDAGFTLYEHAFLLLDGSETSLWEVEHTATPDGRHMCEVYGDEQT 236
WP_008743012 170 ENADRPGEELARRLRTAYAHQITQAFGgRPGlagGRDTGFSLYEHAFLLLDGSELSLWEVEHTATPDGRHMCEVYGSEAA 249 Streptomyces sp...
WP_069920652 165 ENADRPGEPVAARLRSAYAHQITQSFGgRPCasgGREAGFSLYEHAFVLLDGEELSLWEVEHTATPDGRHMCEVYESEAA 244 Streptomyces su...
WP_053679640 165 ENADRPGERLAERLRSAYAHQITQAFGgRRSlmsGRDAGFSLYEHAFVLLDGSEVSLWEVEHTATPDGRHMCEVYESETV 244 Streptomyces sp...
WP_112450821 165 ENPDRPGESVSLLLRSAYAHQITQAFGtRQClsdGRNAGFSLYEHAFVLLDGSELSLWEVEHTATPDGRHMCEVYETETA 244 unclassified St...
RSS78206     164 ENPDRPGERVAGLLRSAYAHQISQAFGgRQCrsdGRDAGFTLYEHAFVLLDGSEVSLWEVEHTATPDGRHMCEVYETESA 243
WP_045321468 164 ENRDRPGEGVAALLRAAYAHHITQAFGaRQFlpdGRGAGFNLYEHAFVLLDGSELSLWEVEHTATPDGRHMCEVYESEAA 243 Streptomyces sp...
WP_030238859 165 ENADRPGERVATLLRSAYAHQITQAFGgRQCladGRDAGFSLYEHSFVLLDGTELSLWEVEHTATPDGRHMCEVYESEAA 244 Streptomyces la...

WP_040022251 309 ARAAMEIRARVR 320 Streptomyces sp. 150FB
WP_234386465 242 ARAAMERRARVS 253 Streptomyces sp. ERV7
2_pfamImport 237 ARRAMENRTRIC 248
WP_008743012 250 ARGAMELRARVR 261 Streptomyces sp. Mg1
WP_069920652 245 ARGAMELRARVR 256 Streptomyces subrutilus
WP_053679640 245 ARGAMELRARVR 256 Streptomyces sp. WM4235
WP_112450821 245 ARGAMELRGRVR 256 unclassified Streptomyces
RSS78206     244 ARGAMESRARVR 255
WP_045321468 244 ARGAMELRARVG 255 Streptomyces sp. NRRL F-4428
WP_030238859 245 ARGAMELRTRVR 256 Streptomyces lavendulae
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