Conserved Protein Domain Family
DUF6218
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pfam19726: DUF6218 
Family of unknown function (DUF6218)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000696) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the gentamicin biosynthetic gene cluster from Micromonospora echinospora.
Links
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Statistics
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PSSM-Id: 437558
Aligned: 12 rows
Threshold Bit Score: 193.079
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
OKI28650      12 MTaEPLEHSALGLLPTRaadgrTMIGHVIVCRaGAGQD--DAIAVWHLDTEGSRTGAWVRPAATALTEPETARSLLDLCK 89 
WP_106180604   1 MS-VPETQDGLGGAAEA-----WAPGSAILAT-GAGEDg-DSVAVWHVSPGGVPTGAWVVPREEAFGSPDAARRLLVVVE 72  Prauserella shu...
WP_043725978   1 MT-EVLDDIA-VVGAAPae--lSAPGSAVVAL-GPGAAg-DEIVIWHVDPHGSPTGWWTFPQAEVFGDVEAARRVLALLE 74  Kutzneria sp. 744
WP_156131695   1 MT-QT-DELGHGLPVAVae--lWAPGSVVVAR-GHDDEghETIAIWHVSPQGAPTGAWIETRQSYRSSAETARRLTTLLE 75  Amycolatopsis m...
WP_093089064   1 MT-TL-EGQS-----VPadvptWATGSAVLTA-DS-----DTLAVWQVSLDGRPTGAWITPLDELRAEPDTAGRLVNCVE 67  Pseudonocardia ...
WP_139190977   1 MT-EPTPPPRPAAARTRtadgrVMIGHAVVAR-GPGEDgaDSVAVWQIGTHGAQVGTWLLPV--AALDAERAGKLLAQCE 76  Actinokineospor...
WP_281262142   2 VI-----DSSPAPLSDRaaderSASGHVVVCRcG------DVVAVRVVDVLGERTAAW-----DAVLSGETARRALAECA 65  Umezawaea tange...
WP_092777125   2 TT-DQLKPGSLGLLSTRagdgrTMIGHVVVCRaGSGQE--ESIAIWHLDTEGARTGAWVTPAAEAMTEPETSLRMLSLCK 78  Actinokineospor...
WP_077008597   3 TT-EPLEHSSLGLLPTRagddrTMIGHVIVCRaGSGQD--DAVAIWHLDTEGVRTGAWVKPATMALTEAETARSLLTLCK 79  Saccharothrix s...
WP_155892996   6 IE-EATSEVANDLATTGpatlnGAPARSLATL---SKHgrSQVAVWQVNFAGVACGAWLLDA----RNKEHALDILALCD 77  Intrasporangium...
WP_089015500   1 ME-ASENELS-----VPvdyvpGARGHGVLAV-GPDSGggDALAVWRLSPTGRAGGAWVVRFDEIERDPEQLRRIMSMLQ 73  Micromonospora ...
WP_095565191   1 ME-VPENELS-----VPvdyvpGARGHGVLAV-GADADgsDALAVWRLGPTGHATGAWVVRLDDAGRDPSPLCRILETLR 73  Plantactinospor...

OKI28650      90 RKALLAWDPAGAVRTLRELEQAAGVPQTD--WSACAVAVRDLVAEVADIRAAYAKRVAEEKAG-KKNIVDLDWAIAL-PE 165
WP_106180604  73 RRAVTAADPRRLPELLGGLTRTSGVDRAEw-WRDQVFSPVDAFAEIVARRAEFERTVADTRAS-GKNVSGLDWPREFrPA 150 Prauserella shu...
WP_043725978  75 RRAITSRDPEDVPVLMTRLTGVAGLDTGPw-WTAQVFSPIDSFRETVARRHAF------ARLD-G----PMHWIRDF--D 140 Kutzneria sp. 744
WP_156131695  76 RRAITAPGEDEIDAVVGELTTAAGLAETGw-WRRQVFAPSGVFEEIARRRQSIEDVVENARAE-RKNVAALDWPREL-PD 152 Amycolatopsis m...
WP_093089064  68 RRAIALSDVSRADTVLSELTTCAKLEDGw--WRGQTFDVAGAFGDVLERRAGVEHAIAAVRES-GRKTTDIDWRRDL--G 142 Pseudonocardia ...
WP_139190977  77 KRAIVAWSADEPLDVLATLERAAGARPRE--WR--LVLLPDALGEIAEVRARYAAAVKAERAA-TSTVPSLEWQVGI-PD 150 Actinokineospor...
WP_281262142  66 GRALLAWESDRVLDVVRQLEEVAGVTSAE----RVVVEIPEVLAEIAEARAAYAEVVAEHQAG-HRESRDLRWLVAL-PE 139 Umezawaea tange...
WP_092777125  79 RKAVLAWDLAEAIETLRALEQVADVAPTN--WNDCGVTLPELLSEVADTRTSYAKRVAEEKAS-KKSIADLEWSIDL-PD 154 Actinokineospor...
WP_077008597  80 QKALLAWDPAEAANTLRALEEVAGVPRTD--WSACAVALPGLLAEVADIRSAYTKRVAEEKAT-KKNIVDLEWAIDL-PD 155 Saccharothrix s...
WP_155892996  78 RRAVID-DSPSSVQLILELADMARVEIPEavMKERLASLDGLLSATAAARRAHAEAVVAYGKSeGKKLAPLAWRTEV--- 153 Intrasporangium...
WP_089015500  74 DRCLVDWDRDIPIGVLARIAEVVPADQLTa-LQGNILTIPELLAEISEHRSTYTAAVEQHRAStRSKLAPLAWPTEM--- 149 Micromonospora ...
WP_095565191  74 DRCLVDGDERKSTAALAAISEFLPASLPTa-LRRHTVAVPDLLTEIAEHRARCADAVERHREGtGSKVAPLAWPTEL--- 149 Plantactinospor...

OKI28650     166 PMPATAEDFESFARFg----ELVAPSAAATEALRISRVGGWVVQRWRETVVALGR-PYLRATFGPPTVLAPEWETRLADA 240
WP_106180604 151 DVPGEFGGLRRLASL-----AEVPGKPVVAEALTVARVLGWLVRLWTETEQVKNRrDYLRAAHGAPEPLPPSWFAAVRIA 225 Prauserella shu...
WP_043725978 141 VIPPDFDALRQLSALhatshATSRATAAQAAAQTASRLLRWLVGLWLETEQVKGRsRPVRAAHGAPEPLPPSWLSAVLTA 220 Kutzneria sp. 744
WP_156131695 153 VMPRDVEGVRTLAGI-----GKGPGASAGAQAITVARVLRWLVQLWTETEQVKNRrSYVRDALGEPEALPPSWLAAVRTA 227 Amycolatopsis m...
WP_093089064 143 GPAGSIAELLRLARL-----GVPSGSPAVSDALAVVGVLRWIAGVWEETEQVKNRrDYVRTALGPPEPLPPRWREAALAA 217 Pseudonocardia ...
WP_139190977 151 PIPATAEEFRRHARVp----RRRDTALVAQEALLTCAMMTWAVHRWQETAGAWSRrDHLRRACPAPGVLPPAWERRLADA 226 Actinokineospor...
WP_281262142 140 PLPTTAEQLRRRARI------VVAGGPETAEAELIASLGTWVVRRWQENVDVLERrEYLRERFGPATVLPARWGKLVADA 213 Umezawaea tange...
WP_092777125 155 PLPATVEQLEHLARVg----NLVAPTESATEALRISRLGGWIVQRWRETTVALGR-PYLRDTFGQPTVLAPTWEARLADA 229 Actinokineospor...
WP_077008597 156 PLPATVEHFERLTGLg----ELIAPTVAATEALRIARLGGWVVQRWRETAVALGR-VYLRATFGQPTVLAPKWEARLADA 230 Saccharothrix s...
WP_155892996 154 --PPSLDQLRPSQYR------GWAGKGTAPHAFGMSVLSRQLVQLWTDTETVRLRrKYLREQFGPAQVLPEAWRDAALAA 225 Intrasporangium...
WP_089015500 150 --PDQQDLAAWAARA-----DCTAASPVAATALALTAAIASTAQLWQATEQARYRrVYLR-SLGDPQPLPPRWLARLREA 221 Micromonospora ...
WP_095565191 150 --PAPRDLAEWTARA-----GSAATSPAAAAALGLTATVARVAQLWHDTEHARYRrSYLR-GLGEPSPLPPQWLARLRAA 221 Plantactinospor...
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