Conserved Protein Domain Family
DUF6216
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pfam19723: DUF6216 
Family of unknown function (DUF6216)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001055) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the yersiniabactin biosynthetic gene cluster from Escherichia coli. This family appears to be predominantly found in Proteobacteria.
Links
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Statistics
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PSSM-Id: 498222
Aligned: 19 rows
Threshold Bit Score: 224.148
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_036542363   8 MVNNISSLPIPLLNMIIILIAfLGLRSFFHYRTGTSYGFVSRLYALLAGRSDYQDKTLGEFWQQNKELERFNAVFNFKAK 87  Nitrincola laci...
WP_074869378   9 VAEQTLELLHSAAPMLALLGT-GCLLFFTLNRSGTAHFVRERIWRLLGGSEEIDNTFLAERWREIKDLESLRYKTGIRFA 87  Atopomonas huss...
WP_056366639   1 MNAIFVAGIGPLVTYFLPILGlIAVAGYAIFRLNSTQIIREKVWSSFIGDKDFSDVRLKSFSYEQLDLARFRVVYGVPAQ 80  Burkholderia sp...
WP_052901901   8 LLNLIVDYNNYINIAFILLVI-LSAVGYIWRKAGSAYSIINRIWFLIVGGKKYHHPEIEEFYQYSSDIEKFNVNFNMSAD 86  Winslowiella in...
WP_034936046   4 LIQTVIKFDTLISTLIAIGII-LSMVYVFYSRSGSTYSLYYRLWSLLVGEKNFHDVHLESYMQERKDLDKFNAIFNTDIK 82  Erwinia malloti...
WP_036190771   5 TFEIVADFLPGLSFILLI----IFAAIWFRLRAGTSYGLLNRLYAIVIGGKEFHDSSIAEYWNERKDVERFNALFNTRAK 80  Marinobacterium...
WP_008365830   9 LLTFTFQNWTVVTSILGVVIV-VIATLYVYRRSGSFFFLRDRVWRFFDGKQTFDDPRFEKMRKRARELEFFRFEFNIPVK 87  Pseudomonas sp....
WP_043188073   4 QTFTSVMHILDVLYKLWPIACgLLVIGAVFWRTRSFFFLFHQILKWLGLEGKYTNTDDQKVADEYLDLNKFNLKTGFRLK 83  Pseudomonas rhi...
WP_012917083   6 FFTGKIAFGSIAGIAIAAVIT--------CWRAGSFYPVNARLLRFFISKDEIEDPDIRQNLADQAALVSFRMTHGVRSR 77  Xanthomonas alb...
WP_078758574   6 IFANSVFITSGVAFTLAAAFT--------CWRAGSFHPINARLLRFFISKDDIEDPVIRKDLADQAALASFRMTHGVRAQ 77  Novilysobacter ...

WP_036542363  88 SLSDAQKLIKWFNEYDLDHKKFARLGNSFDTEKLQIQ-------------RATIGQVIGFILLGIAlaimslapLDLGIK 154 Nitrincola laci...
WP_074869378  88 NLDDAMQMFKWADELGVSADDLMKSAKYYNPAEQTFAnpqqklkrwegrvYCAGLLLAAVFGGFLL------------VT 155 Atopomonas huss...
WP_056366639  81 SINDLHRLLAWMDRNQISPIDLMHARKWIDPSKEEPLqcpsk----kliwRQFGVFFVSIICFTVL--------TTTFTA 148 Burkholderia sp...
WP_052901901  87 STGHILKFKQWTLKYGVAVRMLSSIRGYFDIERLKVR-------------KGSVPLIVVALFLCAAftlaavipAIIAAQ 153 Winslowiella in...
WP_034936046  83 KKNDLDDFYKWLVRYDIDIKKISESKGNFDFHNMKMR-------------KPHWMLIIMAAIFSVLmfifgvaiAAISIT 149 Erwinia malloti...
WP_036190771  81 SLKDIQHFRLWIEKHDLDSRTFTSIQRWFDFEKRKVK-------------KLNTWQLALPFIGTFLyvllssplIPLATA 147 Marinobacterium...
WP_008365830  88 SFSDAERAEKWITQHQLPINDVSLSRSIINWDDFADIrlrtylttqniftLLRVCVITLFLLTIAS--------TLLIAN 159 Pseudomonas sp....
WP_043188073  84 SVKAKTQLHGWLNENDLEFAEVRHAGWYFKANKLIFEipsr-----mqiwVFRVLFLALGCLFVATg-------SILQNP 151 Pseudomonas rhi...
WP_012917083  78 TIIDAKRLALFSKEKNLPLDLIGKAGWVFDLKKLEINpkriph--ggwpvGAAILLFFFIFAMIIS--------AAIASV 147 Xanthomonas alb...
WP_078758574  78 TLSDAKALLAFSEESNIPLYLVGRAGSAFDKKSLTLTrshgsa--krwlgGLIILFLPLFLTLIML--------LAATAS 147 Novilysobacter ...

WP_036542363 155 NAALVKFKDETQWIWLAHDTASNFTYYNIfrdgnNDWVLAAQNCSNEAFsikvAATETQL-KTETIANICKSF---TSEA 230 Nitrincola laci...
WP_074869378 156 DHTLIKVKQSSTRVWTDGESLFAWNR--------LQWSMTLDDC---------AKDITFLpDTHVRKVVCDLIk----PE 214 Atopomonas huss...
WP_056366639 149 KTTLFKMKVSEVWFSSNGSSVDAIW---------GRWKINSESCMKRTLp---GASVSKM-TDAETLAICDGL---ANGK 212 Burkholderia sp...
WP_052901901 154 NAALLKLKPDEPWIWLSENHATKFLKSSQq----DRWKISAEQCANDASnqqqLQAATAL-SADSISAICQAF---SSKK 225 Winslowiella in...
WP_034936046 150 DKAILQFHDGEPWVLINHNMAKPMF---------NKYIITPKDCLKENYnankIMEKTKF-YLSTVETICHSF---NSNT 216 Erwinia malloti...
WP_036190771 148 SSALLKFKDEEQWMWVNETAASSFSYNPFrn-knSDWRISPELCSQSTFdpaeVSKQVKL-QPKNVQIICNAF---DDPK 222 Marinobacterium...
WP_008365830 160 PFVLMHFKQNGPSFYVAKNQVYLEI---------GAAPLTVADCSSAEKl---APFTTKDfTSNRLDVLCQILl----PP 223 Pseudomonas sp....
WP_043188073 152 DQAMLKVTATDTWFWVGKNEATSVRFDLPgtlrgDAWKIQQHDCRYGDAp---VPLDSSW----DKDVICRLVlgfND-- 222 Pseudomonas rhi...
WP_012917083 148 DDLLITIKGTDTSLWLSKDEARKVRPFFG-----ARSRFSKDDCLEIKN----IDTPAGF-HPGDTKILCDIW---KNPS 214 Xanthomonas alb...
WP_078758574 148 SRLLVTLKATDTWLWLGEKEAEIASPFSLk----NHEPLYVSSCNGDSIe---QSPAAGF-SRKETQILCDIW---GDAE 216 Novilysobacter ...

WP_036542363 231 DAKYINELIKGQNIFL-VLTALLVLF------ALASFTELFRRLTAIETAEYLAERKRIK 283 Nitrincola lacisaponensis
WP_074869378 215 AKEYLQQAVTSQKYVAvFFEAILGVL----------FCWVMNWQRKVALAQRIYSKSQAQ 264 Atopomonas hussainii
WP_056366639 213 LEAVTIDAIEQQRTVLgTIAVLTFLA------ALKLLHRVIAALRARELIDQLRSKENAP 266 Burkholderia sp. Leaf177
WP_052901901 226 DRQYIHETIASQKVFW-WFTGLFLVM------AWFFYREGIKLGRIFDGRKMLLTKYRHY 278 Winslowiella iniecta
WP_034936046 217 DKEIIDKFVASQKKVS-WLTFVILYV------SFRFFIFSTRGVCARDCRTYIKKQLIIK 269 Erwinia mallotivora
WP_036190771 223 STNQINEFIADQRLLW-IAVVMSWLF------AFNSFKEAIRRADAHRARPYLHNKLVMA 275 Marinobacterium lacunae
WP_008365830 224 FSDGHEGRIADQREISaLLTAEIFAC------LVFAIRLLAKVKAARRLERQISVRNGCV 277 Pseudomonas sp. M47T1
WP_043188073 223 --SYIADAIETQKTSG--LALVFMGSlsfvlvAIFTFWQLTAV----KLQRRIIGEDLST 274 Pseudomonas rhizosphaerae
WP_012917083 215 LGKSLEKEIHTQHWAFwWAFVMCALY------ALMIFRVMNQWLSQIELNKMILLDKMQE 268 Xanthomonas albilineans
WP_078758574 217 LQVHLEKEVRKQRITLiLPIAFLLWC------LYENFVAIRKWSSVTELGPLLADQAGVV 270 Novilysobacter spongiicola
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