Conserved Protein Domain Family
DUF6206
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pfam19709: DUF6206 
Family of unknown function (DUF6206)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001063) is described by MIBiG as an example of the following biosynthetic classes, polyketide and NRP (non-ribosomal peptide). It includes a member from the undecylprodigiosin biosynthetic gene cluster from Streptomyces coelicolor A3(2). This family appears to be predominantly present in bacteria.
Links
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Statistics
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PSSM-Id: 498211
Aligned: 37 rows
Threshold Bit Score: 263.363
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q28L84         3 DLTSSIRAA-LADGGTVASDKRT----FGIPMRPLTGPLEGHILAVYRGGRDPEVQELLARRHDSYIDCLRLAGVRVPDT 77  Jannaschia sp. ...
WP_121898988   5 ELNRAVRDA-LADRGDPVSRLGY----FCAPFRPRSGPLSDRVIKTYRGGRDPEVLELLARRHDAYAACLRDAGVTLPET 79  Rhodophyticola ...
EST35934      12 SLETQVKEAlRSADDKALTVLGYgevtLVLKLETSRGDFACKRLPIF---PTQERFERYAQSFYEYIARLEVGGVRVAPT 88 
WP_070197394  12 ALEEQVRAAlRTADDRELTVLGYgevtLVLRLDTETGSFACKRLPVF---PTRERFARYARSLEEYLTRLADAGVRVAPT 88  Streptomyces oc...
WP_075024809  12 RLERGVQRAlATPDATALDVLGYgevtLVLRLETGAGSFACKRLPVF---PSRQRFDRYRRLLDAYLSRLGERGLKVADT 88  Actinomadura ma...
WP_100202848  20 ALEERVAGAlRTADDSALEILGYgevtLVLRLATGQGAFACKRLPVF---PDRDRFERYRHSLDEYLERLGKGGLRVADT 96  Streptomyces ca...
WP_107017265  12 QLEDRVRAAlRTRDDSALDVLGYgevsLVLRLESGDGAFACKRLPVF---PDGGRFERYEESLREYLRRLGDNGLDVADT 88  Streptomyces di...
1_pfamImport   1 RLEQRVREAlRTADDGALDILGHgevtLVLRLRTEGGTYACKRLPVF---PDRARFARYREGLDEYLRRLTDSGLNVADT 77 
WP_016638820  12 QLESQVRQAlHTTDDSALDVLGYgeitLVLRLRTEAGSFACKRLPAF---SDPARFESYRRSLDEYLRRLAERGLTVAPT 88  Streptomyces au...
O54147        12 ALEDEVVRAlRTTDDRALTILGYgevtLVLRLETDAGTFACKRLPVF---PSRERLDRHSALVDDYVTRLDKGGVAVAET 88  Streptomyces co...

Q28L84        78 HLRLLD-EAGMQRPVIVQKAVPEEMMLGPLILNASPEAAIDLLDRVATDVAEFWRRVAQR-PERVGFHAQIERFGMDDDG 155 Jannaschia sp. ...
WP_121898988  80 RFLVLE-EAGFQRPVILQKALPPETMLRDMLRAADLKTAIALLDQAAISIAGFWAAVARR-PERIGYHPSIRNFAMGQEG 157 Rhodophyticola ...
EST35934      89 QLWSTShPSGGIAAYCVQETLPSERLCSRLLHTEGDG-------WAEDFFGRFLDCVDGAvSSSLGLDAQASNWVDLDGE 161
WP_070197394  89 VLWTMPlPSGKVVAYCVQRALPADRLCSRLLHTEGDA-------WAEQFFGRLLAVVDGAvGPCLGIDGQAANWVDLDGE 161 Streptomyces oc...
WP_075024809  89 RLWHQArPSGLIVAYCVQEELPGERLCSTLLHTENEE-------WARGFFKRFLDTVDRVvVPDLGLDAQASNWTDVGGE 161 Actinomadura ma...
WP_100202848  97 LLWHLPlPSGRIVAYCVQRELPAHRLCSRLLHGADEA-------WAGDFFARFLDRVEQAvSPELGLDAQAANWMEVDGE 169 Streptomyces ca...
WP_107017265  89 ELWHTRlPSGRITAYCVQRELPAHRLCSRLLHTEDDI-------WIKDFFSRFLDRVERAvEPTLGLDAQANNWMDVGGE 161 Streptomyces di...
1_pfamImport  78 EVWHAPhPGGRIVAYCVQRELPERRLCSRLLHTEDET-------WAKDFFSRFLDQVDATvSPTLGLDAQASNWVDVDGE 150
WP_016638820  89 EVWHTRaPSGRVTAYCVQRELPSERLCSRLLHTEDDV-------WAKNFFARFLDRVHATvHHGLGLDAQASNWIDMDGE 161 Streptomyces au...
O54147        89 RMWHRRlPGGRAVAYCVQEALPEGRLCSRLLHTAGEA-------WCEGFFARFLDRVEATvTPRLGLDGQASNWIDVDGE 161 Streptomyces co...

Q28L84       156 PLFLDTFPPLISYSRDEMGHLIQRFADNGLVRGLGKVLPGRL------RDMQDRWYTPAGSVQTLIEGALRLRPGD-AED 228 Jannaschia sp. ...
WP_121898988 158 PIFFDTFPPLIGYSREEMGRLLLRFSESRLIRGIGPILPERI------RAIQDEWYSPAGTIVGLIGSAVRLRPDD-KAD 230 Rhodophyticola ...
EST35934     162 LVYLDITTPLM---RDDRGREEL---DVRLFFTSLPWLLRDAvrvsmtKSIFDKFYSTRGVVLDFLGNLHKERLEKlVPA 235
WP_070197394 162 LVYLDVTTPML---RDERGRERL---DVRLFFSSLPWALRDVvrlsmtRSIFDKFYSTRGVLLDFLGNLHKERLEKlVPG 235 Streptomyces oc...
WP_075024809 162 LVYLDITTPLM---RDGRGRERL---DVKLFFTSLPWALRDAvrismtKSIFEKFYSPRGAVLDFLGNLHKERLGHlVPV 235 Actinomadura ma...
WP_100202848 170 LVYLDVTTPLM---RDGRGRELL---DVRLFFTSLPWLLRDPvrlsmtRSIFDKFYEVRGVLLDFLGNLHKERLGHlVPV 243 Streptomyces ca...
WP_107017265 162 LVYIDVTTPLM---RDARNRERL---DVRLFFSSLPWFLRDAvrvsmtKSIFDKFYETRGVLLDFLGNLYKERLHElVPA 235 Streptomyces di...
1_pfamImport 151 LVYLDITTPLM---RDARGREKL---DVRLFFTSLPWVLRDAvrlsmsRSIFDKFYATRGVLLDFLGNLHKERLDAlVPA 224
WP_016638820 162 LTYLDVTTPLM---RDTRGRERL---DVRLFFTSLPWVLRDAvrlsmaTSIFDKFYEPRGVLLDFLGNLHKERLDSlVPA 235 Streptomyces au...
O54147       162 LVYLDVTTPLI---RDERERELL---DVPLFFTSLPWLVRDVvrmamtKSIFDKFYTPRGVVLDFLGNLHKERLDHlVPR 235 Streptomyces co...

Q28L84       229 ILEWADRFATTRLeGPWRNAVQAQLARHARAAklnvGRWSAIT 271 Jannaschia sp. CCS1
WP_121898988 231 LLDWARGFAETHLtGALKDEVMAELDTPPRLP----TIWTATR 269 Rhodophyticola porphyridii
EST35934     236 YLSR----VNPRLdVPLTEDEVADYYREDA------RMWEMIQ 268
WP_070197394 236 FLDQ----AAARVnPALTVGEVAAYYRDDA------RMWELIQ 268 Streptomyces oceani
WP_075024809 236 FLEQ----AAERLdEPITAEEVAAYYKEDA------RMWELIQ 268 Actinomadura madurae
WP_100202848 244 FLER----ANARLaKPITEREVAAYYRDDA------RMWELIQ 276 Streptomyces carminius
WP_107017265 236 FLEQ----ANARLsRPITVEEVAAYYRDDA------RMWELIQ 268 Streptomyces dioscori
1_pfamImport 225 FLDQ----ANGRLaEPITAEEVAAYYRGDA------RMWELIQ 257
WP_016638820 236 FLEQ----ANARLaQPLTAEEVAAYYRGDA------RMWELIQ 268 Streptomyces aurantiacus
O54147       236 FLEQ----ANARLdRPLDAEEVGAYYRDDA------RMWELIQ 268 Streptomyces coelicolor
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