Conserved Protein Domain Family
DUF6197
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pfam19698: DUF6197 (This model is not part of the current CDD release)
Family of unknown function (DUF6197)
This entry includes a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus. Structure prediction suggests these proteins contain five alpha helices forming a compact domain.
Links
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Statistics
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PSSM-Id: 523736
Aligned: 335 rows
Threshold Bit Score: 31.2529
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_183342626   45 RRLDRVRAALEQARVDL--VEQGWTQRAWFSVSSDGgagttrlasvaesfdlvrptssVSGACLVGALLRRAEDp----- 117 Microlunatus a...
YP_009281659    1 MS---VKETLTAAKELL--KTSGWGKGDLIKGDG--------------------------CLCALGAVGLATGHea---- 45 
3_pfamImport    1 STTLDKINNLTAAKELLlaDENAWGRGDLLIRRVDG----------------------SKCMCALGAIGVAAAGed---- 54 
17_pfamImport   1 TSTLDTLNTLIKARELLs-EEGAWTDGELLEYKDDG----------------------TKCMCALGAVGVAAGFesemel 57 
56_pfamImport   1 MN---TIEILEKAKELA--PEK-WDEGASLGYSDS-------------------------PCCILGLVGHARFGe----- 44 
YP_009208472    1 MN---TIEILEKAKELA--PKR-WSRHRELGLRP------------------------NEPCCILGLVGVARFGn----- 45 
31_pfamImport   1 MS---AIDILEKAKALA--PEK-WLPHHLLGLPGE-------------------------PCCILGLVGYATFGd----- 44 
12_pfamImport   1 AAKQAAVEVLETAKKRLe-PKNAWTTGSLWHRSRYFn---------------------QDCYCALGAIASAVVPn----- 53 
YP_010060665    1 MNNQEIAEIIENAHDVM--VERGRTTGKLIDPDT-------------------------CKVCLLGAIGVAGIGee---- 49 
YP_009214309    1 MNSNEIAEIVEKAHDEM--VARGRTTGNLIDPET-------------------------CEVCLLGAVGVAGIGee---- 49 

WP_183342626  118 ---dRATtHAD-VW-GAVDELYEALHERMGHTflppgrvd-sharrhaKLGVLTAWNDDRRTRREDVLDVLDRAVSR 188 Microlunatus anta...
YP_009281659   46 --aiRGDdYDIfDEdPKASAAVKALVDQIPEKtlkklw----ldtsnpDYSFIHEFNDWSQTTEEDVLALFDKAIQA 116
3_pfamImport   55 --avLEKsYALfEEdGLSREASLELARTINEGlfdeia-----irertEYSTVYWFNDTWKRHREEVIELFDTTIKR 124
17_pfamImport  58 gkydVFDdRSErVD-PTAYAAVLALLKPLDARyt-------------kRYTSVFMYNDRFD-DAGPVLEWFDKVIED 119
56_pfamImport  45 ---sWDHsYISlDEdGDAAAAVEALAAVSLPYgg-------------daQEKVYRHNDAHLKTVAQVQSFIDRAIEN 105
YP_009208472   46 ---dWVPsYRSlEGdAEASAAVEALAAVSL-Ktg------------adAVAQVYTYNDRHLKTVAQVQSFIDRAIEN 106
31_pfamImport  45 ---dWKPsYTSlELnPDARVAVEYLAAVSSSTsg------------egDQEKVYLHNDTCLRTVKQVQSFIDQAIWN 106
12_pfamImport  54 ----EQIsYVLfEEpGPVQDAVKAVSDVVVGEvrkvdegy-aethdatVHMNVYRFNDRIAKGADDVIQVFDEAINN 125
YP_010060665   50 --elKKThYDEfHAgGKLRPVVKELVKDLPDAklpamsw--grlreylDHTDLYDFNDNYADTE-DVLDLFKRTANR 121
YP_009214309   50 --klKKTlYEEfYYgGKLHPVVKELVKDLPDSalqemygspaplrshlFYDDLYCFNDTYATTE-QVLDLFKTTAKR 123
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