Conserved Protein Domain Family
DUF6185

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pfam19683: DUF6185 
Family of unknown function (DUF6185)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001485) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the 3-demethylchuangxinmycin biosynthetic gene cluster from Actinoplanes tsinanensis. This family appears to be predominantly found in Actinobacteria.
Statistics
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PSSM-Id: 498191
Aligned: 9 rows
Threshold Bit Score: 847.512
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
RLL70790      19 ADDVCNTGQLKSVRATASVRFTHEDENYSKAEGRLTIKVPKSWSQASDLLLNGDTERHRTAMRCLLRSPDDD------AF 92 
WP_045303442  36 AADGCHAEQLVTARTEAVLRLVNHAQTVIEGKGDMTVQVPTTWALANDLMLSESSDAYRLAMRCLLREEQGSpr--fqDL 113 Saccharothrix s...
WP_030555691  72 SASSCHAEQLTAAHVNVELRLANHAHTTVEGRGVTTVRVPRSWEYAEGLLLEKSSVSYRNAMRCLLRDEQESgrppqqYL 151 Kitasatospora a...
WP_087882475  34 SDGSCDARGLRTATVEAHLRIDHEDRTYAKASATTTLTVPMSWRPAPHLLLSTGSDRYRRAMRCLARGDHDGv-----ET 108 Streptomyces
PGH51583      22 AGDPCHSAWLAGERAEASISLDHRNRTHTKVTTRLKVRVPSGWPYASGLLMGEESEEYRRAVRCLTRGPESH------TD 95 
WP_159424440  10 APTDCRADQLKTAEVTALAEFKHRGNDWSMVTSTMDISVPAAWTHASDLLLDTHAPAYRLALACLVGKPLQNq----iDF 85  Streptomyces sp...
KKD05254      18 ADDACSAGQLKTARVTASVRLEHNGENYTRAAGVLTVKVPKSWPRATDLLLNGDTEPYRAAMRCLLRPSDDPl-----PW 92 
WP_109498937  28 DEDPCESRALRDAEVTSSVRIRHDGEDYTRAEADMVVKVPKSWPLSDDLLLNGDAAAYRAAMRCLVHDAYDDy-----PY 102 Streptomyces sp...
KOV73586       9 EPDNCRSLPLKDAKVTTSVRLEHDGQDYTRAETDLVVQVPKAWKPAADLLLNGDTEQYRAAMRCVLRYPDELy-----PY 83 
RLL70790      93 RDTEGRTRAPKVTVG----------KKWVTVDQRVMTWVVALGTREFGPWKLTVHPRLWNLELVRPSALDDSWWQEITVD 162
WP_045303442 114 RTDEWRPHRPQVTAE----------DSWVKVQYQTVFWFDQRGTFTVGPWAVDMHAERWKLSLTPPTALAGARWDRVQID 183 Saccharothrix s...
WP_030555691 152 RGREWRSSNPAVSVE----------PDWVEVEYPTIFWFDQPGMFRVGPWEVDVQPGQWKLSLVPPTALAGARWDSVAVD 221 Kitasatospora a...
WP_087882475 109 RWEEWRVKDPAVKPAtapsgeesshKRWLEVRLSAHAWVAQRGTVAVGPWTVEVSRTRWDVRLTPPDTLGQARWHEVTVD 188 Streptomyces
PGH51583      96 RWSERREGLPRVTPG----------RDGIDVEVPAYTWVDSGGPRPVGPWQLTAGATRWEIRFTPSPALGRADWKRVTVD 165
WP_159424440  86 RDYEFRSKPVTVKAD----------GRRVKVHYEAATWVQFSSSDAVGPWVLTVSKENWRIALRPSPALTGADWDKVQVD 155 Streptomyces sp...
KKD05254      93 RDTEGRTAPPRVTAQ----------KTWLTVEQHVTTWVVSLQDRDFGPWRLTEGDRLWTLELIRPYALDGAWWQEVTVD 162
WP_109498937 103 RDTEWRPWPPRVTVG----------AKTITVKYRAVSSVDSPTERRFGPWRITPGKRLWTLSLERPPALAQSWWREISVD 172 Streptomyces sp...
KOV73586      84 RDTEWRPWPPKVTVQ----------KKWITVEHRAVTYVEDLRDRDFGTWRISAGRRYWTLTLVHPPALATAWWQEITVD 153
RLL70790     163 LGGRAARSVSSSPTSGATTD-LTWSTA-KPGGAPPEVRVTLQPPAAKASAARWSN--QPWF-----VVDALLWLLLQVVF 233
WP_045303442 184 LGGLDAFEVAPTPTAVDSEN-LVWSGLgQPGGPSTAVTVQLVPPWQRALATANTS--RGWR-----VVNAAGLAAWWAGT 255 Saccharothrix s...
WP_030555691 222 LGGLEASSVAPEPSAAGNGT-MRWGDPdRPQESSSLLTVRVAPPWQRAWAAVSGK--SAFL-----VSNKIGMAAWWVAM 293 Kitasatospora a...
WP_087882475 189 PGRPGARSAEPRATTKEDGGaLVWRP--SRAQGAPSVEVGIEPAWPRAFAALDDS--PPYA-----VYSAVGGSLWLIAA 259 Streptomyces
PGH51583     166 PGAPGAETASPPPARGEGGTtLVWEPP-DGRAEAPAVRVVVKPAWQRSWAARYND--QLFF-----NASYAGELLWDIGL 237
WP_159424440 156 LGGRGALTATPRPAFGERGTrLNW----RHKEPDQNPTVTFRPPTLQYWDFITTSpeKTWQawepwGIYSATAAFWYAAS 231 Streptomyces sp...
KKD05254     163 LGGRSARDVSSAPTTGVATDkLTWTRE-KPGGAPPEVRITLQPPATKASAARWSE--DPWF-----VFDPLVWVLWSAAI 234
WP_109498937 173 LGNRGARDIWPMPTKGSANE-LTWTWA-KSDMPMPALWVRMQPPATKALTLRWEEg-APWY-----LVRSVTWVSWDLAL 244 Streptomyces sp...
KOV73586     154 LGGRAARSMTPVPTKGSDTK-VIWTRA-KAGGEPPQVQVRIQPPATKAMIARWNE--APWY-----LVRSGIWLSWETAL 224
RLL70790     234 LVLLLVVVRTVRRTPATTPRADSEVRTVRnlLSVGW-------------LTFAISVVQLLASPALGYLAEQSTGPYWMrd 300
WP_045303442 256 SAVIVVAAVRARRQPAGAVATPVERSSSG--ALLRWgllna----vvgvMILLLYLLIPDAAKAVGEPGPWGDERRWQ-- 327 Saccharothrix s...
WP_030555691 294 SAIVALAALRARRRPAHIEATGLEIRSST--VLLQWglvsa----vvslTFLPPQYTLLGQDR-------------WK-- 352 Kitasatospora a...
WP_087882475 260 VVAVWCALIVLPRHGV---PDPVEAKAVTn--LRNWs-----------lTLLGVALAVQGRDVSLAAAGAFENTPDWArg 323 Streptomyces
PGH51583     238 LAAVLYGARRTRGSGA---GAPAESRALRnlVVTVWctflllrivdgddVFFHLPSVDVGHEPLIS-------------- 300
WP_159424440 232 GALLLVAGRRLRRSLADT-TTPEESSALH--YLRWWalllm----flgvLGYMDDNVYLWFQRLVG----------WHhd 294 Streptomyces sp...
KKD05254     235 LVLILVGARALRQTPVSSPVTDAERITVRnlRSMGW-------------LTFVFSAVELLDDGLLAHFDNEGVAEFWTdr 301
WP_109498937 245 FPVALLLIRRLSRSPA--LQTPAEAATRRnlLLWVW-------------LMFVMSLLFELADDLTRLSS------WWQsh 303 Streptomyces sp...
KOV73586     225 LPVLLLLVRRLSRAPATSLATPAEDATRRnlLIWAW-------------VWFAGALVFELDDQLPSIAQDYEVFTWWPdy 291
RLL70790     301 qriplhFGLTVLTGLALCV-FGRPGRTAGGLVAAA--TGYVTVVVCRPHWLALPSQLLLD--WEnfpdeahhfqeTHAMV 375
WP_045303442 328 ------VLIGVLTGWALTV-TARPRASVLLAASLT--AVAGTLVAVLPGLFGLPPTLVPQqpPP-----------ASGIA 387 Saccharothrix s...
WP_030555691 353 ------ILIGILVGWALTA-TARPKRSVLLAASLV--AAVGGLVAGWPSLFGLPQKLFPPgtGS-----------VHSFA 412 Kitasatospora a...
WP_087882475 324 aayapyAWLTSAVAGALLLcFARPTRAVALLGAVL--GVGAAVPVLLPGVTGLDper---------------fvqPPGPG 386 Streptomyces
PGH51583     301 ------LATTGAVGLTLLL-LGRPRRTVLAAGLLL--CALPLAVLVSPGSFGLDEGFDVPgnTS-----------YGAGA 360
WP_159424440 295 yewtvaVFVLAFLGPALCL-FGSRSKRLLFSVGGVvlGLLGWYVVSEMFDFTLLptad-------------rllsTPGWT 360 Streptomyces sp...
KKD05254     302 hriavhLVLMLLTGLALCV-FGRPGRVAVVLTTAA--TGYVVAVVCRPGWFGLPSGLLLD--SGddaqtvewfrrAGGMS 376
WP_109498937 304 rv-awyLVLGTGLGIVPSL-FGRPRVAARVAVAVA--GVYPVVVAVRPGWFGLPADFWLDqmITdevl---raerTGGFW 376 Streptomyces sp...
KOV73586     292 ra-lihFGLAVCGGAALCL-FGRPRWYAMLAVGVA--TAYTGFFVGLPGRLGQPEHLWL---FTedvtaierlqvTGQFL 364
RLL70790     376 AFAM-----ACACVILIWLVGAVASLLRLWRALDA----------PVAGRPWGrfp-hsLLAALIAGSTVVTTVSVWAAE 439
WP_045303442 388 ALVL-----LTAAMLWLWLTGLVLWVRLIASDGGLlr------epANPLRLRG------TGAALAALTVLLLGWALWARE 450 Saccharothrix s...
WP_030555691 413 PLVA-----MTAALLWLWLAGLALWTWRLACEGGLir------tpASPWRLRR------LGPVLAVITILLLGWEWWTQD 475 Kitasatospora a...
WP_087882475 387 YVTVgvvwgATVCSFALPLLGGALAVRRLAVDGGL----------WRP--RRQrprtwlLMTGVGTVVALIGGSYAAAVE 454 Streptomyces
PGH51583     361 ALAA-----AAWCLLCLGFLGVTAAVWRPARDCGLlgdrpprvpgGPPGPRRLrl--rvAGPLVALAALGVGASYATATE 433
WP_159424440 361 MAAV-----ACTALTAVCWIGLITAGQRILLI------------------RETriptrmMVAAALAAATATVLWAYLAFD 417 Streptomyces sp...
KKD05254     377 LFAL-----ACACGVFVWLVGTTASFLRLWRSCDA----------TAPGSSRGrfp-lgVLGALLAVSAALPAVSVWTAE 440
WP_109498937 377 WLAL-----ACVCVAFVWMVGGVSALRRIRAGVDVq---------NTATPPRGtfp-wwVLPVCAAGAVVLPALALWATH 441 Streptomyces sp...
KOV73586     365 WLAL-----ACVCVAFVWLVGFLSVLQRLRAARHIq---------VADEPQRGyfp-wwGLVLCAVAATAVVALCVWAQH 429
RLL70790     440 NLWEHQSWLSRRNGNDl--------------YGLRHVTAVFNDLRWFPVDWLDWFYGGslWW----------------WC 489
WP_045303442 451 GYWERISWLTDRTAPA---------------YGSLHLLVLSQQAASLAASVPAWCFSH--AW----------------VL 497 Saccharothrix s...
WP_030555691 476 RGWERASWLSDRSVQE---------------YGWLHRSFLSEHLVSYTIQLPAWCVAG--TW----------------VL 522 Kitasatospora a...
WP_087882475 455 RDWNRASWLSPRLDPTrlviddsgavqrewgYGAWHQAELRSSLLWFTETSQWWWFGM--WW----------------VL 516 Streptomyces
PGH51583     434 RDWLRTSWPSDRTDAY---------------YGMAHLADAMNEIGWFTPNAQNWWFNAf-WW----------------LP 481
WP_159424440 418 RYWERISWLANPRSAD---------------------------FQKFRGGELSW------WWltfptnvldpllvvvsIL 464 Streptomyces sp...
KKD05254     441 NQWEHQSWLSSRADER---------------YGVWHTAELFNEVRWFPSDWLDWFHGMyfWY----------------WG 489
WP_109498937 442 NAWSQTTWLSTRDDF----------------WELWRFVYHYNELAWFPSYMSGWWFVTvcWW----------------YG 489 Streptomyces sp...
KOV73586     430 NTFEDQSWLSRADDS----------------YDRWHFVTLYDELVWFPSNWPDWFPGTicWW----------------YG 477
RLL70790     490 PSLAILALLRARAKAtanpQAVV---PTPADLCILKVFFIYSVGPVVGWYAG-VPLPLLPMLALWLALTG--LLALGTKR 563
WP_045303442 498 TGVAIVALLRARGTG----LPVPyanPAELDRLLLAVFFAVVVAWREGSYAGsQVLASLWLVLDIAALYG--LLAVGQRW 571 Saccharothrix s...
WP_030555691 523 TGIAIMALLRARDLA----FPVPcadPTRLDCLLLAVFFAVVVAYRQGSYAGsQAGAVLWLVLDIAGFYA--LLAVGKRW 596 Kitasatospora a...
WP_087882475 517 TGLAVLAVLRSRAVRtaraTTLArrgPKAVDRLLLLLLFPVMAAMDIGVYTGsEAVVGSWFFLNFFALAG--ILRLTGRR 594 Streptomyces
PGH51583     482 ATLALLALLRARAHRpg-sSPIA---PEGPDHWWVLVFFPLGVVGSFGWFTAnGALTWLWLPVTMGALHL--AVASGRRR 555
WP_159424440 465 APLPVLGVLRVCRVEqheqGAFT---PAPAEKFLLVALFAITFAPD-AYYFG---FSAYALTLVLCLCTAwgVLVLGSHF 537 Streptomyces sp...
KKD05254     490 PSLALLAALRARAAAaa-qSAVL---PSPVEIRTLMVFFVVCSAPIVGWYAG-VPLPVLPLLALWLALTA--LLAYGTRR 562
WP_109498937 490 LAAALLAVLAARAAAph-dEPVA---PEGPTLLVLALLSFQFVWPTPGWYVG---LWLSPVTVPVTLLTGflLLAVGRRR 562 Streptomyces sp...
KOV73586     478 GIFALLSVLSARAAAsg-gSPLS---PDRPELLVITVYFVLSVAPIPGWYVG---LSFLLLSAALVLLTGlfLRVVGERR 550
RLL70790     564 AILYRKLSSGHR---LHELVKEPDRQHLLRAARQHRELHAQLRRLEQGQQDE---------NRSKLERELDRLHRLPHPA 631
WP_045303442 572 AVLNQHLEGCAAaptLGEAIAEAGHRDLIERARRYRELTTVLRGLDQGHGEGa-------lGRHAVEKELNRLHRWRQVA 644 Saccharothrix s...
WP_030555691 597 AVLAQHLEGSGDtprLSEAITEAGHSDLIARARRYRELTDELRDMEPGKSEGaasrhaaekERHAVERELSGLHRWRSPT 676 Kitasatospora a...
WP_087882475 595 AVPARPSSGSGEp--LATTLSATHRARLLDRARRYRELHAGLRGA-AGQTDEdt------aARRDMETRLRRLHRWRAST 665 Streptomyces
PGH51583     556 AVLEQPLERSGVp--LGAAIGEADRVKLLDRARRFREIHAQLRRLDQGQSDDea------hSRRAFERELRGMHHWNAPS 627
WP_159424440 538 SVLEQPFADNAP---LGRTISLTDRADVLRLARRFRERQTRLSQLSTSNLGErs------aERQSIEAEIDRMDQ----- 603 Streptomyces sp...
KKD05254     563 SVLYRELAPGVP---VFEVAKGYDRQKLLKDARRHRELHAQLRRLEQGQEGS---------ERDQLEYELDRLHRLPHPS 630
WP_109498937 563 AVLWQKPLPDKPdklLRHAIRESDRSWLIESARTYRDLHSRLRRLEQGDPEG---------RRQQMEQELDALHHWNPPG 633 Streptomyces sp...
KOV73586     551 SVLSRKLENGTS---LSEVIRESDRHWLFDSARRYRDLHSQLRRLEQGDQDA---------KREELEEQLDQLHRWNPDD 618
RLL70790     632 PPSGlPRTwiRLPASISPVELALAWGPQGTSWDNAWRAARLTALFSVPAVVILTWANQ-VRGDQWGEKYFQRFGLAETVM 710
WP_045303442 645 QGAV-ARP--WLPSQVTVVDIALSWGPHARWWDNARRAALLAAAVGVPGSVILVWSAY-APQEQWMLTRQNLFGVPDLVW 720 Saccharothrix s...
WP_030555691 677 GTANtARP--WLPVQFTVMDIALSWGPHARWWENARRAALLAAAFGLPGTLLILWFLYqGEQTEWMHTAQDSFGAPEMIR 754 Kitasatospora a...
WP_087882475 666 GSPD------RLPRDVSVVDAVLALGPCDTWWENGVRAARFTQPVALVFSAVLVWDKQ-LRGDALTNTLYDRIGLPDVAT 738 Streptomyces
PGH51583     628 GRAD------RLPGAVSVVDAALAWGPRATWWGNGRHAAARAALWGLPATGLLVWADM-LRGEFLTGTLDYGFGIPDMVA 700
WP_159424440 604 ----------ALPAGVRPADLPFACGPMATWWGNARRGALNACLIGLPATGLMYWVDV-VKGDSWMLYAENAAGFVWIVG 672 Streptomyces sp...
KKD05254     631 PPPGlPNTwiRLPDSVGPVELALAWGPRARWWENACRAALFAALIAVPANGVQVWVDH-IRGFLWEDKFLNRFGFAETVT 709
WP_109498937 634 ATAPfAGA--RLPESVDVVELALAWGPRATWWQNACRAALFTALIALPANAVSFWADN-IRGSLWDSVTRDRLGIVGLLA 710 Streptomyces sp...
KOV73586     619 TAGPhAGE--RLPDSVDAVELALAWGPRDTWWHNGQRAALLAALFALPATGVSFWADN-VRGPLWGDVANNQFGVIGLVD 695
RLL70790     711 HALEVELIWIGAGFTLGALWRVLPGRRGPVRAFGLALAYAAPVFVQWAGDWMVDQPINNWPLNLSLTLLVLTLTGVAMDI 790
WP_045303442 721 RFASWELVWAGAGLVMGALWRLLPGRRGPARALWLVAAYSMLIALDIMGNLITDQTLGAVALAICLMLLVLTLTSLAMDA 800 Saccharothrix s...
WP_030555691 755 QFLLWELTAAGAGLVLGALWRLLPGRRGPTRALSLTAVYTLLIILGILGNLLTDQPLGNWAIAICQMLLVLTLTSLAMDA 834 Kitasatospora a...
WP_087882475 739 QFVLWQIGYAAAGFLLGALWQELPGRRGPAKALALAVAYALPIGVFSLGNWSLGEEQTTLAFAAASMLLILTLTGVRMDV 818 Streptomyces
PGH51583     701 AILYWEIGWAGAGFVLGVLWRRLPGRRGLVKALPVAAAYAVPVGADAVGNLLTGESQYTLALYVSAMLLVLSVTGIGMDL 780
WP_159424440 673 EILTWQVWWIVGGFFLGALWRDLPGRHGPTKALFVTLAFAIPATADFLIVQAIGGTVPQLIGQIAAFGSVTTCTGLMMDL 752 Streptomyces sp...
KKD05254     710 ALIEWEVIWAGAGFVLGALWRELPGRRGPGRAFWLSLVYATPVLLHWVGVRVLDQSFGTWAFNLTLTLLVLTLTGVAMDI 789
WP_109498937 711 DAVDLELCAAALGFVLGALWRVLPGRRGPAKALGLFVVYAVPVAAHWILTRATGQTFGTWALDLALTLLVLTVTGVVMDI 790 Streptomyces sp...
KOV73586     696 HVITSEFIWAGAGFVLGALWRVLPGRRGPAKAVGLSVVFATPVVAHWIISTAVGQPIGTLALHVALTLLVLTSTGVAMDI 775
RLL70790     791 DTFRGERRYWPTRAGLLLSLYQWRTASVQVAFLVAQIVALVTIWQQLKGNEPMIL 845
WP_045303442 801 DTFRAERRFWPSRFELLLSIYQLRGLSVQIAYVMAQLAVVISIWKFLAGPDLRSM 855 Saccharothrix sp. ST-888
WP_030555691 835 DTFRAERRLWPSRFGLLLSIYQLRGFSAQIAYVLAQLAVLIAIAKFFIGPDIRTM 889 Kitasatospora aureofaciens
WP_087882475 819 ETFRGELLPGRGSLSLLPVVYRTRYLSMQFAWVLAQAAAIATIVQFFADNGGPPW 873 Streptomyces
PGH51583     781 ATFRGERRYWQSGLGLLLSVYQMRAFSLQMASVLAQVIALVTIWQFFGDQVGAPP 835
WP_159424440 753 QTFQNERRYWPTNASLVAYVYQMRFAT--IAFFMAQLLALVTLWKTFADVSAKGP 805 Streptomyces sp. 3214.6
KKD05254     790 DTFRREGHYWPTKAGLLLSVYQWRTASLQVAFLVGQIVALVTIWQQMQGADPMVL 844
WP_109498937 791 DTFRQEGIYWPTKASLLLSIYQLRTASVQLAFLVAQVVALVGVWQQLKGNDPMIL 845 Streptomyces sp. Act143
KOV73586     776 DTFRQEGHYWPTKAALLLSIYQLRTASVQLAFFVAQVVALVGVWQQLKGNDPMVL 830
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