Conserved Protein Domain Family
DUF6182
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pfam19680: DUF6182 (This model is not part of the current CDD release)
Family of unknown function (DUF6182)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001774) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the spicamycin biosynthetic gene cluster from Streptomyces fimbriatus. This family appears to be predominantly found in Actinobacteria.
Links
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Statistics
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PSSM-Id: 523733
Aligned: 19 rows
Threshold Bit Score: 225.355
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
SCF77210       8 LSPELLLTVAAERLRAARPDLPAHWNLSTPHALLAAKEHVLAda-aSGRTDRALAVAVVRDFRLTSWIREACAFALSLPS 86 
WP_067159202   5 AIQERLREASAARIRTARPELADAYDLTSAEGLLAVRARLDAadapGERAPEHLAAVVLGRFDLTSWARATCEFALGLTP 84  Streptomyces sp...
WP_065967438   3 LSQDLLRAEAARRVQVARPDLAAGLDLSTAAALAEAHARIQE----SADTDGLLAVSVVRRFELAAWTRATCEFAIGTAP 78  Streptomyces sp...
WP_071808317   2 ATQEHLAALLHERLIRAGINAAT-----------------------LEPEHDHTVVAVLRRFDVTTFAESALRFAAGLTD 58  Couchioplanes c...
EST39301       2 FTQEYLRAQAVSRLLAARDERAEQPCTDGPAGESIAELAARA----AAEAAPTTVTVVLRRFDPPAFARAALEAVSGYPE 77 
WP_073762297   3 LSQSLLRSRAAERVRAAHPALAAKFDLEDADGLLAAQSEIAS----LAESSDTQAVVVLRRFSLAAWVRATCGFAAGVSP 78  Streptomyces sp...
WP_057238243   3 PLQEDLVDRAGRRVRHARPDLAERFDLSTLAGLLDAQQSVAA----AASAEETLVVAVIHHLELAEWAGATCAFAFGLDP 78  unclassified Ki...
WP_014133235  11 PAQDRLRHAAAGRVRRARPDLAARYDLDTTEGLLEAQQAVATragdGAGEEGTLAAVVVRHVDLAAWVRSTCEFALALDP 90  Kitasatospora
WP_130881190   3 PVQHHLREAAAARLTAVRPDLATRHDLATLDGLLAARADVAA----AGDEETVLVAAVVHRFDLDRWIRSTCDFALGLDP 78  Streptomyces sy...
WP_067244895  10 AAQRTLRAAVAQRLRRARPELAARHDLSTPAGLAAAAAQA------AEAAHDTVVAVVVRDLDLAAWARQTCAYTLGLGV 83  Streptomyces sp...

SCF77210      87 ERADVWRRSFTRTVYLAGRPDNLRERFAFTHIADDSSAAWAGPSPDETTTGLRRLLKTFSGRRPLTAWR-PATVEIPrtd 165
WP_067159202  85 EQTAAWRRSFTRTVFLAGNPDNLRERFSFAHLAEDGSAAWTAPGPAADSAGLRRLLKLFAGPLPLPVRA-DTVIEIP--- 160 Streptomyces sp...
WP_065967438  79 ERLAAWRRSFSRTIFLAGNPDNLGDRFRFDHIAEDGSAAWAGPAPAAASAGLRRLLKLFDGSRGLPPRP-DTPVRIP--- 154 Streptomyces sp...
WP_071808317  59 EEGADWLAALTRTAFLAGNPVNLRDRFPPSHLAADETIAWYGPAPPADFTGLRRLLKAF---------P-AGTLRVP--- 125 Couchioplanes c...
EST39301      78 ALRGDWFRAYTRTVFLSGDPDNLRRRFAFHHVSGDGAMAWTLPGERGEQTSLRRLLQLFPDSPLPALPGrQPVVEAT--- 154
WP_073762297  79 DRAVRWRQAFTRTVFLAGNPDQLRERFAFDHISEDGSAAWRGPEPASASAALRRLLKRFDSERALPIGP---AVRIPla- 154 Streptomyces sp...
WP_057238243  79 VAGARWRRSFTRTVFLAGNPANLRERFRFAHVAGDSTAAWTTPGPGPNASTLRRLLKLFDAPAGPPARP-DTLVRLP--- 154 unclassified Ki...
WP_014133235  91 ALARPWRRSFTRTVFLAGNPDNLRERFPFAHTG--AGAAWTPPGPDKDTAALRRLLKTFDGPAGPPARP-ATDILIPag- 166 Kitasatospora
WP_130881190  79 VRADAWQRSFTRTVFLAGNPLHLRDRFSFASVADDASTAWTPPGPAAATTGLRRLLKLFTGSAPLCGHS-GITVEIPta- 156 Streptomyces sy...
WP_067244895  84 EEAGAWRRSLTRTVFLAGNPEHLGARFPLVRLAPDGSAAWTVPGPPAATVALRRLLKLLQAPAQVPTGR-DVSFEVPhpa 162 Streptomyces sp...

SCF77210     166 ---asATGRHDRRRPV-HR------DLYLATAHVTVSDALVQLGHLLAEAVIDGTVGAGDRLTVRSVPRLTGL-ATPYAA 234
WP_067159202 161 -----SRAGGTDRAPV-HR------ELHIATADCQVSDALVHLNHLLTEAVMDGLVGPGDVLTLRHFPRLTGI-TERFAA 227 Streptomyces sp...
WP_065967438 155 -----EAIGPRHRPPV-RR------KLYVATAGSTVADTLVHLNHLLVEAVLDGLLAPGDTLTVRQLPRLIGL-PGPYAA 221 Streptomyces sp...
WP_071808317 126 -----------ARVTV-GEvgthscRLRLATAGLSTAAYLVHLNHTLAEALLRGLLRPGSALVIDHVPELADAdLRTAAM 193 Couchioplanes c...
EST39301     155 -----DAEGPTSDGET---------RLDLATSGVTRAGYLVHLHHVLAEAALTGRLKNASGLVLRHLPQLDPA-DGPYTM 219
WP_073762297 155 ----gPDHGSHARHPV-RR------DLYVATSGMALSAYLVHVNHLLVEAVMDGLIAPGDELTVRELPSLVGA-SVPFAS 222 Streptomyces sp...
WP_057238243 155 -----------GRPTTgHR------DLYLATEGCSLADALVHLNHVLVEAVLDGLIAPGDSLTLRQVPRLIGI-ATPFAA 216 unclassified Ki...
WP_014133235 167 ----pGPHGPGGRAAR-HR------DLYLATAGCTLSEALVHLNHILVEAVLDGLIAPGERLTLRQIPRLTGI-EAPFAA 234 Kitasatospora
WP_130881190 157 ---hrPAPHPAHRPPV-RR------VLYLASAECTVADALVHLNHTLAEGVLDGLIAPGDRLTVRLLPRLAGV-LGELER 225 Streptomyces sy...
WP_067244895 163 sydapGAVRPPVRPPV-RR------DLWLATADCTTAAALIHLNHLLAEAVLDGLIAPGDRLTLRRTPRLAPR-QSDYAA 234 Streptomyces sp...

SCF77210     235 LR--VDTDRHRPSELQAYAGLTQEN 257
WP_067159202 228 LR--VDTEPTLPGRLRAAAGLTEET 250 Streptomyces sp. ERV7
WP_065967438 222 LR--VGAEPEHPGRLRAYACLTGET 244 Streptomyces sparsogenes
WP_071808317 194 IR--VHRDTTDPDRLRAYTCLSTSD 216 Couchioplanes caeruleus
EST39301     220 LRaaVAEPSAAGGRLRAFAGLTGAP 244
WP_073762297 223 LR--IGVDACRPDRLRAYAALTEEI 245 Streptomyces sp. CB02923
WP_057238243 217 LR--VVTDPHRPDRLKAAAGLTEET 239 unclassified Kitasatospora
WP_014133235 235 LR--VVAEPHRRGRLKAAAALTEEI 257 Kitasatospora
WP_130881190 226 VR--VVTDPRSPDRLMAAAGLSKAR 248 Streptomyces syringium
WP_067244895 235 VR--AVPDDHDPRRLRLTAALTTPS 257 Streptomyces sp. DSM 15324
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