Conserved Protein Domain Family
MCAfunc
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pfam19584: MCAfunc 
MCAfunc domain
MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N-terminus. In MCA proteins, MCAfunc has Ca2+ influx activity and is proposed to be a functional domain of MCAs. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3 like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.
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Statistics
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PSSM-Id: 498129
Aligned: 3 rows
Threshold Bit Score: 254.486
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_021603873  24 LIGMIVKAANTARMHKKNCRQFAQHLKLIGNLLEQLKISELKRYPETREPLEQLEDALRRSYILVNSCQDRSYLYLLAMG 103
1_pfamImport   1 LIGLIAEAANRARLHKKNCKKFAHHLKLIGNLLEQLKITELKKYPETREPLEQLEDALKRSYLLVHSCQDKSYLYLLAMG 80 
NP_001324197  25 LIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQIKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYLLAMG 104

XP_021603873 104 WNIVYQFRKAQNEIDRYLRLVPLITLVDNARVRERLEDIEKDQFEYTFDEEDRRVQDVILKPE 166
1_pfamImport  81 WSIVNQFKRAQDEIDRYLRIMPLLTLVTNARFKERLERIQRDQYDYTLEEDDRKLQTAILNQK 143
NP_001324197 105 WNIVNQFEKAQNEIDLFLKIVPLINMADNARIRERLEAIERDQREYTLDEEDRKVQDVILKQE 167
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