Conserved Protein Domain Family
POU2F1_C
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pfam19536: POU2F1_C (This model is not part of the current CDD release)
POU domain, class 2, transcription factor 1 C-terminal
This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localised adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.
Links
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Statistics
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PSSM-Id: 523714
Aligned: 9 rows
Threshold Bit Score: 155.844
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005457864 399 NTPIKSIFTPSSPLVASTASLDSSptiTTPTTLTVNPV-MPLTNTSIANLSFTG-TAVGA--TNTASVIS--TAPVVSTA 472
5_pfamImport   1 STPIKAIFSTSTALAPSTASLVTS---TTPTTLTVNPV-LPLTSTSVSSMGFTV-TTVGApsTNTASVIS--TVPAICTA 73 
XP_013867088 347 NTPIKTIFTPSSPLVASTASLVSSpsiNTSTTLTVNPV-MPLTSTSVSSVTFTG-TAVGG--TNTASVIS--TAPVNATS 420
1_pfamImport   1 CTPIKTLFTPSSPLVASTASLVSSptiNTPTTLTVNSV-MPLTSTSVSSLSFTG--VYRC--TNTASVIS--AAPIFTTA 73 
XP_008326261 419 STPIKTIFTPSSPLVASPACLVTSstiNTPTTLTVNPV-MPLTSTSVSSLSFTG-TTVGA--TNTTSVIS--NAPMVTTA 492
2_pfamImport   1 STPIKSIFSPTSPLVASTASLLTS---TTPTTLTVNPG-MPMNSTSVSGQTFTGtTASGAt-TNTASVIS--TTPMVTTV 73 
XP_015219792 442 STPIKAIFPNPNTMVPSTASLVTS---NTPTTLTVTNL--GFTGTT-------G-IGPAT--TNTASVIS--TTPVASSA 504
XP_055500290 477 ttttktIFHTPTSMVASTSNLVTS---STPTTLAVNAMqMPVSTAGVTSFSISGtTASGTapTNVASVITglSSAVSTST 553 little skate
XP_011606442 382 STPIKTIFTPSSPLVASTASLVSSptiNTSSTLTVNTV-MPLTSTSVSSLPFTG-TTIGP--TNTASVIS--TASMVTAA 455 torafugu

XP_005457864 473 TSSPSLSTSQTSNQSTTTESKAGTQAQTIFTQAPSSIATSLGTGQVMVAAPGLS----------AALQGAA-SLP-SASF 540
5_pfamImport  74 TSSPSLSPSPSALHASSSESSVAQEPITTVTQAPSSLASTLASGQVMVAAPGLS----------AALQGAT-QLPtSASI 142
XP_013867088 421 TSSPSVSPSTTTFQSTSTDSKA--GLHAIVTQTPTSVATTLGAGQVMVAAPSLS----------AALQGAA-QLStSSSF 487
1_pfamImport  74 -SSPSLSPSPTTIQSGNSESKV----QTILNQVPTSIATTLGTGQVMVSASGLS----------AALQGA--QLP--GSF 134
XP_008326261 493 TSS---SSSPATSQSMTAESKT--HAAAVPTQAATSIGTTLGTGQVMVAAPGLS----------AALQGA--QLPtTASF 555
2_pfamImport  74 TSSPSLSPSPTALRST-AVETGGTHEQAAVTQAPSSLATTLGTGQVMVAGPGLS----------AALQGAA-QMPtSASF 141
XP_015219792 505 VTSPSLSPSPTSLHAP-ITESPSSQETSTTTQAPSSMSSPLGSGQVMVTAPGLS----------AALQGAAtQLPtNAGL 573
XP_055500290 554 VASPALTPSPSASISVTESSSSGDTNTTQTTSTG--LINPLCTSQIMVSASGLQtagtalqagiAHIPTGA-GLAtNPSL 630 little skate
XP_011606442 456 NSSPSLSPSPTINQARIAESKA--VSNAQTSITPTSIATTVGAGQVMVASPGLS----------AALHSAA-QLPtSASF 522 torafugu

XP_005457864 541 AAMAAAA-GLNPALMASSQFTQGGALLSLAPGGLGSALSPALMSNSTLATIQ----ALASSGTIPITSLDG-SNLLFANT 614
5_pfamImport 143 AAMAAAA-GLSPGLMASSQFTPGGALLSLAPGGLGSALSPALMSNSTLATIQgvwsALASSGTLPITSLDGsGNFLFANA 221
XP_013867088 488 AAMAAAAaGLNSSLMTSPQFAPGGALLSLTPGGLSSALSPALMSNNTLATIQ----ALASGGTISLPSLDA-GNLLFANT 562
1_pfamImport 135 AAMAAAA-GLNSGLMASSQFSPGGALLSLT-GGLGGGLSPALMSNSTLATIQ----ALASSG---ITSLDG--NLLFANT 203
XP_008326261 556 AAMAAAA-GLNPGLMASSQFAPGGALLSLTPGGLSSTLGSAFLSNSTLATIQ----ALASNGTIPITSLDG-SNLLFANT 629
2_pfamImport 142 AAMA----GLNPGLMASSQFNPGGALLSLAPGGLGGALNPAMLSNSTLATIQglwsALASGGTLPITSLDGsGNLLFANT 217
XP_015219792 574 AAMAAAA-GLNPGLMASSQFSPGGALLSLNPGTLGSALSPALMSNSTLATIQ----ALASSGTLPITSLDGsGNLLFAN- 647
XP_055500290 631 AAMAAAAgLTNPGLMSAPQFAAGGALLSLNPGSLGGALGPALMSNSTLATIQ----ALASSGTLPITSLDAsGNLLFANa 706 little skate
XP_011606442 523 AAMAAAA-GLNPGLMASSQFAPGGALLSLTPGGLGCALSPALMSNSTLATIQ----ALASSGTIPITSLDG-SNLLFANA 596 torafugu

XP_005457864 615 -SAGNTPNLVTTPLFLNPQNLSLLT-SNPVSLVSTG-AG-GLQVTADGHHQASTAAVPVQASTITTAPK-AQ 681
5_pfamImport 222 -SAGSTPNLVTAPLFLNPQNLSLLT-SNPVSLVSAGgAR-GLPEPSTCTLPLTPTTVPSPRRPCLPPQS-PP 289
XP_013867088 563 -SAANTPNLVTTPLFLNPQNLSLLT-SNPVSLVSTG-TG-GLHVTTDAHHQAASAAVPVQTSTITTASK-AQ 629
1_pfamImport 204 -STG-------TPIFLSPQNLSLLT-SSPLSLVSAG-PG-GLQVTSDAHHQASAAAVPVQASTITTASK-AQ 263
XP_008326261 630 -SGSNGSNMVT---FLNPQNLSLLN--NPVSLLSTG-G-----LQVDAHHQSTA--VPVQTSTISTASK-AQ 686
2_pfamImport 218 -SAGSTPNLVTAPLFLNPQNLSLLT-SNPVSLVSAGtAG-GGSLQVTADHQVTTTTVPVPASTVTMASK-AQ 285
XP_015219792 648 --ANAGGNLVTAPLFLNPQNLSLLT-SNPVSLVSSAaASaGASAQALNLQVTSAAGESNQSAVTSVAGPaAA 716
XP_055500290 707 aSAGGAHNIITGPLILNPQNLSLLTsNPAVSLISAA----GTTGHAPSLQMASMTADSSQNSSFTVTSAgGA 774 little skate
XP_011606442 597 -SAGNTPNLVTTPLFLNPQNLSVLT-SNPVSLVSAG--G-GLQVTADTHHQPTT-AVSVQASTISTASK-AQ 661 torafugu
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