pfam19532: Ig_TMEM131L_2nd (This model is not part of the current CDD release)
Transmembrane protein 131-like, second Ig-like domain
Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localisation. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein was firstly described as containing three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. Using structure prediction models from AlphaFold, it has been possible to identify the CHDs as Ig-like domains. This entry represents the second Ig-like domain of TMEM131L and the third in TMEM131. TMEM131 is a collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII.
Jiyao W et al.(2023). "The conserved domain database in 2023.",