Conserved Protein Domain Family
DUF6056
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pfam19528: DUF6056 (This model is not part of the current CDD release)
Family of unknown function (DUF6056)
This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 448 and 528 amino acids in length. There is a conserved NYL sequence motif.
Links
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Statistics
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PSSM-Id: 523709
Aligned: 59 rows
Threshold Bit Score: 214.451
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_021770419   2 TRHKGL----QTAVVALSIFALLY--ALNRMMPL-HRDDYDYSMVWMT-------ARHITSFGDVLESVCRHYLLHGGRA 67  Mitsuokella sp....
WP_092070287   1 MRNIKKscdnTYVYYMTLFFLAML--WLQLFDSFtLSDDLAYHFVWQKdeg--qaLQVIRNFNDLINSQLVHYQILNGRL 76  Prevotella sp. ...
WP_006254804   4 GS--------YSLVLLLMLAALVS--YFSYVSPW-VGDDIEYAYFSAIkdt-ngtNLPIHTLQDIFVSQYNHYQSTNGRT 71  Alloprevotella ...
WP_071456158  30 KKENTY----IKWLVLIITFITIF--TLNQLTYY-TSDDYTYHYVYKGhmp-ttdIEKIDGIGSIVTSQINHYHLWNGRY 101 Vagococcus teuberi
EOL42979       1 MFMKKK----NFLFTVGICFLFIF--VLNYLTTY-ATDDFSYRFVFDHyglptdnPEKITGFFSIVRSMWRHYFAMNGRW 73 
WP_057905531   1 MRKKGYqtlrILGFVAVLGVVYLLfkQLNDYTGY-SADDYLYHFFFTGewp-arhLRGIHNLFDLIQSIQNHTRINNGRF 78  Loigolactobacil...
WP_054733976   1 MKHTAKvligIIGLIVISVGVFLVmkLLNDLSGY-SADDYLYHFFFTGewp-akhLRGIHNGLDLIQSVQNHTRLFNGRF 78  Secundilactobac...
KRN94761      32 NVFKIAsttlASLLVLGIVFIYIL--NINKFAGL-TGDDFLYHFVYTGewpakngARTYQNLWDWVQAIYIHMTQWNARL 108
KRM79118      27 NVLLLG----FSGLVMGIIYLFIL--NLNQFTGY-TGDDFLYHFVYTGawp-sryLNEYHNLWDFVSAVYTHMSIWNARM 98 
WP_003136467  19 NVLRTI----ITLAILSLTFIFIL--NLNHYTGY-TGDDFLYHFIYTGawp-sehLSEYHNLSDYISAVYTHMTLWNARM 90  Lactococcus gar...

WP_021770419  68 VTVFFLDTFLL-LG-KSVFDFANALVFLALVVLMAMHARrGAAFWREPGIFAAAGLLTWLCLPHFGEVAVWKSGSTVYLW 145 Mitsuokella sp....
WP_092070287  77 VVHTIAQFFLS-FTpPFIYQFLNALLFVLLLYLSVRIMH---LSKFKTFASILMCFLLFVVFSGFRTAILWSMGSFNYLW 152 Prevotella sp. ...
WP_006254804  72 VAHCFVQFFCGiGG-QIAFSICNGLMYILLVVLICRLIH--WDWKKPRSVFVTLLLVLFTFN-----TGFTPSCQIGYIW 143 Alloprevotella ...
WP_071456158 102 LAHSIVQFFLQ-YD-KIIFNIFNTFAFILLMYLIYAIIEtRSSIKKPGMLLAQIAMLLWLMIPSFGQTVLWVSGAGNYLW 179 Vagococcus teuberi
EOL42979      74 LAHSFVQFFMS-QN-KLLFDFFNSIFFLLLGWLLNYLASlLLETENDLSNLSFIYPLLWLSLPEFGKSVLWLSGACNYLW 151
WP_057905531  79 VAHTGVQLFMQ-WP-KSVYNIANSIVFLLVGILINLHLF-GRLSRLRVGYLMLTFMLMWVCLPDYGTSILWLSGGFNYLW 155 Loigolactobacil...
WP_054733976  79 VAHTGVMTMMQ-FP-KAVFNVANALVFVVVGWLMNVHVF--GKQRIKVGFLALTFALMWFGLPDYGTTILWLSGGFNYLW 154 Secundilactobac...
KRN94761     109 TSIIFEIAAMQ-IP-KSLFNIINAIVYLILGLEINILAS-GKKFIFQPIKLLITYLLMWFFLSGFGSTVLWVSGAANYLW 185
KRM79118      99 TSIIFEILAMQ-IP-KTLFNILNSLIFVLVGLLLNILVS-GRKAFLKPIHLLLTFLLMWFFLPGIGTTVLWVSGAANYLW 175
WP_003136467  91 TSIIFEILAMQ-MP-KSIFNILNASIYVLVGLLLNVVVS-GKKAFLKFLHLALTFLLMWFFIPGMGSTVLWVSGAANYLW 167 Lactococcus gar...

WP_021770419 146 SAVPVLLFLLPYNvhlrvigTGKEGTLSHRRIFAVPLFLL---GIVAGWSVENLAV----TTVVVSAgis-fyAYRKGAM 217 Mitsuokella sp....
WP_092070287 153 VIVYTLIFLLYLR--------KLYFTDNNRLFFHIIVSPL---SIFIGCSHEGLSL----PISITFFtfi-iaKRKQI-- 214 Prevotella sp. ...
WP_006254804 144 MFCTALGTLYIFQ-----------RQPQLSFFSAILVFLF---SILAGWGQESLNFglcmSFFVFFL------PHFKQNK 203 Alloprevotella ...
WP_071456158 180 TSLFYTGFLLLYL-----------KNLDDHLFVILGSIFL---GFLTGVTNENSGP----ATILVAVcif-llNIIINKK 240 Vagococcus teuberi
EOL42979     152 MSLVYLSYLLVFK--------------KINKYRWYNVFLLiglGILSGATGENSGA----ATVIVVFllw-lfTEHQPKK 212
WP_057905531 156 VALIYLSFLLPYR---------FNYQAQHPRIMFVGMLLL---GFLAGGTNENTAP----LTLFIALgft-icDWKQG-- 216 Loigolactobacil...
WP_054733976 155 MAMIYLLFLLPYR---------FNYQAHHPMLMAIGMSVL---GFLAGATNENTAP----LTLFIAFaft-lfDWQKS-- 215 Secundilactobac...
KRN94761     186 PTTIILAFFIPYRf-----nYRIKVYYSIAAWIAL---IF---GILVGMSNEVGGA----TAIVIVGmftffdRSSGDFN 250
KRM79118     176 PTVVIICFFLPFRf-----dMGSK-----NDWIGFGLFVL---GLFAGLTNEVGGA----TAVLVALlftvynYRKSHGA 238
WP_003136467 168 ATVIILLFLLPYRf-----nVSTK-----RGWEEFYLPVL---GLLAGLTNEVGGA----TTVLLALiftvynLKKSGSG 230 Lactococcus gar...

WP_021770419 218 MP-WMPAGALGALLGLIGLIGAPGNFVRYDAQGSGKGilthignqfagngemvlyilpailllilawrlyrlrmageevg 296 Mitsuokella sp....
WP_092070287 215 LHqAIFLYICWYIIGTILCVISPGIWNRVDGGIPMYNrllsgli------------------------------------ 258 Prevotella sp. ...
WP_006254804 204 AArWLV--LIGFGLGTLMICLSPGAWTRAAQSHQLLNvsllnla------------------------------------ 245 Alloprevotella ...
WP_071456158 241 IKiYQITGILFSVLGFISMMSSAGSQKRGHIDLSIEVlsrnltnift--------------------------------- 287 Vagococcus teuberi
EOL42979     213 LMyWKLISVMSSAISSIILIKSPGALKIESNLSILTSnfft--------------------------------------- 253
WP_057905531 217 QLaWKWAGGIAGAESWIVLVISGSQQVAKRGSQFQIQklltat------------------------------------- 259 Loigolactobacil...
WP_054733976 216 QLaWKWCGGLFGALGFYIMVKSGSQQIAVRGKQFEIGkllqna------------------------------------- 258 Secundilactobac...
KRN94761     251 DLwWKIIGVLSNAIAFVVMLKLSSKSAETQNYGVHDRfavhvvkvv---------------------------------- 296
KRM79118     239 GVlTQAAGVLGALVGFITQLSLSSGSAETQNYGQATGfiqhlsavv---------------------------------- 284
WP_003136467 231 NTvAQILGTVAVAFGFGTQVILSSGSAETQNYGASTGlgqrfldil---------------------------------- 276 Lactococcus gar...

WP_021770419 297 tpserkhgigrFLLAAFVAFLVVsyfnggfvawalrdflvghvlvplgldkpktidhfnnimhgfeemaiywlaiflfys 376 Mitsuokella sp....
WP_092070287 259 ----nlisnvrITWLLVITLLILf-------------------------------------------------------- 278 Prevotella sp. ...
WP_006254804 246 -----hysralYLYLFYALYLLL--------------------------------------------------------- 263 Alloprevotella ...
WP_071456158 288 -nsmihfyffyLLILVLILILSL--------------------------------------------------------- 309 Vagococcus teuberi
EOL42979     254 -------likfSLLLIVPILLSIy-------------------------------------------------------- 270
WP_057905531 260 -----wqysglLLLLVLGVAFYLywqh----------------------------------------------------- 281 Loigolactobacil...
WP_054733976 259 -----ghysgwLLALAFGLLIYLywqh----------------------------------------------------- 280 Secundilactobac...
KRN94761     297 ---egtwtysgPLLIMTLFLAVGliivqrk-------------------------------------------------- 323
KRM79118     285 ----fgtihysgFLLLAIFVLILllflr---------------------------------------------------- 308
WP_003136467 277 ----sgtahysgFLLLPIVVFGVllyfn---------------------------------------------------- 300 Lactococcus gar...

WP_021770419 377 wgkerlglqkariralapvpRCAVLARFP----VAKYASRLIALALFNNFVM-----IAAPTFPARATFSSTVMILIAVL 447 Mitsuokella sp....
WP_092070287 279 -------------------kRNKLEFKAKlyqyRYVYLCLFFSLGIVTVCGT----------NLERVAFFTDFMAMLLLV 329 Prevotella sp. ...
WP_006254804 264 ----------------------FRRAKIG----QFFHTNAFYLIAIFTLLCFnliigISGP----RQLLGIELLSILGLL 313 Alloprevotella ...
WP_071456158 310 ----------------------LKAINAK----DIYFIILLLIGHFACIYSL-----ILVSEQPLRVLFGASVYLVIVTT 358 Vagococcus teuberi
EOL42979     271 -------------------fLYKLSKANVfescHRVFLFIFVTGALASFFSL-----VFAEHSTPRNLFSVAIYLNLMLV 326
WP_057905531 282 ----------------hgygRAFTWRDQR----LYLAGCLYGVGAILGIISL-----IVSPQILSRVFFGPSLYLITALL 336 Loigolactobacil...
WP_054733976 281 ----------------htygHRLVWRQQR----TFVAAWLYGVGAVLGIVAL-----VVSPQILSRVFFGPNLYLIIAIL 335 Secundilactobac...
KRN94761     324 -------------fwkrifsEVARSELER----TMLSGMIFLLGGLAGVGAM-----IFSPVLFPRLWFAVNVLLIIALV 381
KRM79118     309 -------------------rqqmdNTVES----LSVMGLFFSGAGLLGCGAI-----MASPITPARLWFASNILFIIALL 360
WP_003136467 301 -------------------rdqlqEKACN----LWHGGIIFLISGLAGCFAI-----LASPIIPARLWVASNILFIIALL 352 Lactococcus gar...

WP_021770419 448 AVLRDPV-------VAAPIAARGRKLLVtaggALGTFTMAAALVITHEMDEANAARLAIVERAAASGNPI--ACMEPIRr 518 Mitsuokella sp....
WP_092070287 330 ELWSVL--------LSLKWQRYIIICCS----ILMILF----YIPAVAVREENKRNCDYMKQQMSEPEREliAVRQPIKg 393 Prevotella sp. ...
WP_006254804 314 QSQQSFE-------TKRAYNTAFIMLLT----FFTTLIILKRMSFTLQTRTAFDQTMAACR-KAPSGSTV---------- 371 Alloprevotella ...
WP_071456158 359 YLLNRLL-------KLKKSQFILTVGLL----LFSAYHYYNAIQDNRTTYSQVMEQVALLK--NASPDED--VTLPMITy 423 Vagococcus teuberi
EOL42979     327 YLLYLMKd-----yFEKKRPFMINTVLT----LVSLVIYIPVTSQLAENYLEYEQEIAVIEQTKREHKKL--AVVQGITw 395
WP_057905531 337 LLLADYArlrrqawLPTLIPYIVAAVLA----FMSIPTYVAAVNSNFQSYQYWRTGDVRCRQAKQAGQTS--ASVPGQPp 410 Loigolactobacil...
WP_054733976 336 LALKDHAllrqgtwLVRLLPISAALILG----FLAIPGYQAAVRSNLQSYRTWATGDAICREDAKRGIAH--AKVPGMQp 409 Secundilactobac...
KRN94761     382 NFFGAYEmysekslLSRIILMGSALGLL----YLMIPSYQTHMNNLKKSYNVFYTHEKLTAQARKNGEKT--VYLPGMPv 455
KRM79118     361 MLIEAWQelrlqsfKTMFPLIIAVLGVG----FVVIPSYTYNLKDIQNSYQYFYSAQAIARDAKNKEQTT--ARVPGMPi 434
WP_003136467 353 MMFEAWQelraqssWTNVPLCIAILCLT----FVSLPSYDYNLKDIKNSYEYFYTAQTIAQKAKEEGKTS--ARVPGIPm 426 Lactococcus gar...

WP_021770419 519 -----kNRALRHVFFVDF-------------------DNGVTKdGLCKY---FGIANIKVTGA 554 Mitsuokella sp. oral taxon 131
WP_092070287 394 e-----------nhIMDFfreryvnpsaefgfyccymGFNAQDiNMRQAatlYGKKKMIFLPE 445 Prevotella sp. tf2-5
WP_006254804 372 ----------IHYFGSDA-------------------KAWPGDhFLRTM-----EKKIKIETG 400 Alloprevotella tannerae
WP_071456158 424 p----kTNYNAYKGTANVtq---------------drEAWFNK-WMAQY---YNVKSITGIPQ 463 Vagococcus teuberi
EOL42979     396 pdnqlvGLYNPYYKMQYLss---------------dsHAWLNE-WMSKF---YTVKGIRLEKK 439
WP_057905531 411 v----fNDHNMYLSSTYVagg-------------qpdKQWFNV-WMARY---YGLKTVRLNNR 452 Loigolactobacillus bifermentans
WP_054733976 410 v----yTDRNQYVSSTYVsng-------------npnKQWFNV-WMARY---YGVKSVAVDNT 451 Secundilactobacillus similis
KRN94761     456 t----tDLYNPYNGTPYImpg-------------nskKLWSNV-WMAEF---WHVDRIILDND 497
KRM79118     435 t----tNPYNAYDGTPYLvasd------------hpqKEWANT-WFAKY---YGLTRVYLDNS 477
WP_003136467 427 t----sNGYNAYFGTPYLvase------------hpeKEWSNT-WFAKY---YGLEKVYLDDT 469 Lactococcus garvieae
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