Conserved Protein Domain Family
DUF6044
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pfam19510: DUF6044 
Protein of unknown function (DUF6044)
This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 557 and 582 amino acids in length. There is a conserved YNG sequence motif.
Links
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Statistics
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PSSM-Id: 498082
Aligned: 37 rows
Threshold Bit Score: 474.001
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_092045373   8 IGFFFRRFWYFIFIGLFFVCTIV--LYKTAGAGSYFAIHDNLDLFIPQYQMMKNDETFFA--LVAGTDFLDN-ISRNVLP 82  Butyrivibrio sp...
WP_084577509   8 IFNFLVRHKAAFIFTSVLGAYLA--PFIILRQNAHFTINDNLDWITAWT-VLVNSGKTFD--LTGTVSQMLgeLPRSCLP 82  Sporomusa malonica
WP_009035273   3 ADEYDLKSTYLVHLILVLILIFL--PYLWHGEGVKLIVQDNLDSNVSWYTSLKQQGKIYAppWTKVDGMVIS-TPRFSYP 79  Indibacter alka...
SDD40947      46 QQVFKELQLYQFLPFLVLLLFIF--PYLIQGESVFIPVSDNMDSNLAWWKAMKDQGKIFGgwNESIAGMIVE-SPRFTYP 122
WP_091654428   6 IQILNSRKRLVHFLSLIAMAFILimPYVFLGSGVYLPVSDNMDSNLAWWKMLKESGSIWKdwNHEVPGMIIQ-SPRFTYP 84  Algoriphagus or...
Q2FUN5        13 HKIIHSSRLPFLLGLIIVLLYIA--PVLIQWEDAPVLNHDCLDSNVVWYLILGQSGKLFGs-YDGTIEQIMGgISRNSFP 89  Methanospirillu...
WP_021639049   4 FGNVILKKWYWFLFAAVVLGEAA--VFLFFGEGSYIATHDNLDLFMGHFQAMKLWDVFFA--HNAEVPILGG-ITRDYLS 78  Clostridia
EOS30609       1 MKKRIIGNWYVIFIGAFLLSVSA--VYIVFGESSYIAVHDNLDLFMAQFGMLKNTDSFFS--HGVDVPFLGG-VTRDNLP 75 
WP_175475101   4 ITVKIATRWYICLISIFMIAVFA--MFMIVGENSYIAIPDNLDLFVAQYKMMKNTGTFFA--QGANVPFLNG-ISRDNLP 78  Butyrivibrio sp...
EOS74357       3 ELKKLISHWYLVIIAGFLIFAGG--VFFICGKDSIIAVHDNLDLFTPQFQMMKSTNTFWT--HGVDVPFLGG-ISRDVLP 77 

WP_092045373  83 SEFSLYTILYMILPAGKAYVAGYFIKILIAMIGGMLLAYdiltnegidewvrhgvyYVHPvKNDYssTMA--IAILVSFA 160 Butyrivibrio sp...
WP_084577509  83 SGFNIITWLYLILPPFRAYLVNMLLVHSTAFIGMFLLLR-----------------HYVI-SDQR--QAW--LAWAGAAS 140 Sporomusa malonica
WP_009035273  80 SGLNIELSLYSIFSPFVAFALNKALIVIFAFFSMRFLLH-----------------TLEG-RNGPnsQQI----IWWSLV 137 Indibacter alka...
SDD40947     123 SAFSVEGLLYFLFPLFTAYLVNKVLIFILAYVAFWLWIKh----------------QSFA-KLSEklLFL------LPLL 179
WP_091654428  85 SGLNLEALLYYFFPILPAYMINKLLIFGIGFGSFYFWLR--------------------L-QSHEriPFL--VQIGFSLL 141 Algoriphagus or...
Q2FUN5        90 SEFNVVTLLFTFFEPITAYFLNFSIIHLIAFIGMFFFLR-----------------EFYP-GGKE--YRY--LIPGVSCA 147 Methanospirillu...
WP_021639049  79 SEFNLYNILFYLLPPFAAYMCGYFLKILIAEGSMLLLAKdi-------------------yQENYkkYEP--AAVIIGLI 137 Clostridia
EOS30609      76 SELSLYTLLYFLLPPFAAYITGYLLKVAISLASVWMLAKew-------------------yGEDFvkYRP--MAAMMGFC 134
WP_175475101  79 GEFYLYSVLFMLFPTYIAYVLGYLLKIVIAIVSCLLLA-----------------------GDMMenENPgdIAWICAFA 135 Butyrivibrio sp...
EOS74357      78 SEFSLYTMLYMILPDYPAYVTGYLLKIIIALFSCILLAKdm-------------------yGEKYevYKP--LIYLMGFA 136

WP_092045373 161 YGILNLFPAFGIPFAAIPLIIYLLRSVYR----EPSFLKY--LLIFCYPFLSYFSYHGIFIMGYLMIAIIWMWIRH---- 230 Butyrivibrio sp...
WP_084577509 141 FATIPFYTVYGLSIAGQPLLFYAMLNAFNa---KKMTIPA--IIIIIFSLYSSLPLVGVFILAALGLAALYDYWRT---- 211 Sporomusa malonica
WP_009035273 138 WMSLAFYPHRGVSIAGLPMVFALIHQIRLg---EFRGRHI--FLIVIYAFYSMFLLAVMYIWLVFAFWVIFWMIRD---- 208 Indibacter alka...
SDD40947     180 WASLAFYPHRGISIALLPVLILVFEALLQd---KKSWKYF--IFLVCYAFYSKLVLAGFYFFIGLTVWLLWEWIRT---- 250
WP_091654428 142 WASLAFYIHRGISIAALPALVGIFQLFLSs---SGNWKYL--IGLIAYAFYSKLVLAGFYFWIGLLLWVTWKCIVT---- 212 Algoriphagus or...
Q2FUN5       148 FALLPFYPPAGLSIAGLPLMLYGFFSLIR-----DGWRLWslLPLILYSFYSSGVFTGYFLLPILFLYCVLISVYQ---- 218 Methanospirillu...
WP_021639049 138 YGLLPLFPAYGIAFASIPLAVLLLRRIYR----GESRWDY--LFLFLYPLLSYFSYFGFFILGYLVLAIVILAVRDygsm 211 Clostridia
EOS30609     135 YGILNLFPAFGIPFASIPLALYLLLRIYR----KPSVKLY--VLLFCYPFFSYFSYHGFFILAYLLAGIIWLWIRD---- 204
WP_175475101 136 YGILNLFPAFGIAFASIPLVIYLLRKIYRlgfsRACVKYF--ILLFLYPVVSYFSYFGMFILGYLVLAIIWRLIAD---- 209 Butyrivibrio sp...
EOS74357     137 YGILNVFPAFGIPFASIPLVIYLMRKLYK----SPSFKWY--AALFFYPFLSYFSYFGLFILAYMAVSLIWLWIKD---- 206

WP_092045373 231 ----------------------------------------HEFPIRLFVSLVLLVVGSVVFEYRLFMTMLf-SGEVTIRS 269 Butyrivibrio sp...
WP_084577509 212 ----------------------------------------RQNRPKFWGAIALLAGAYCITEVWLIYNAFfsEGFVSSRE 251 Sporomusa malonica
WP_009035273 209 ----------------------------------------RKLHGRLWFFMFFWVLLYAIQDYHYIYYYFfqNDFVSHRS 248 Indibacter alka...
SDD40947     251 ----------------------------------------RTFPKYGSLGLLTLAIAWTCQEAYLIKGLFftEEFQSHRE 290
WP_091654428 213 ----------------------------------------RKIFGLAIFGLFILMGTWLVLEYQLIRGLFlnPNFESHRI 252 Algoriphagus or...
Q2FUN5       219 ----------------------------------------RKVLWRGIYAIFFAGLLFLICDYRLFWEMFlnNSSISHRV 258 Methanospirillu...
WP_021639049 212 kkaapdekngqedvrknvqenarknaqkdaqgktrrpsflRSISLRLAAALVILSAGYILFEYRLFGEMLf-SDVVTMRT 290 Clostridia
EOS30609     205 ----------------------------------------RKAPVSLMAALVVLGLGYVFFEYRLFYVMLf-GGVETIRA 243
WP_175475101 210 ----------------------------------------RKLSLPLCLALVILALGFVAFEYRLFGEMLf-SDEVTIRS 248 Butyrivibrio sp...
EOS74357     207 ----------------------------------------RRFPGRIFLAVCVLSAGCIAFEYRLFGTMLl-SDEITIRT 245

WP_092045373 270 SIVQADM----SPISIVFETLKVWANGMMHANDAHVYIVLPVCVIYFFYLNakyIRSNNAsg------------------ 327 Butyrivibrio sp...
WP_084577509 252 EINRVLLgqsrDWPGVQALIMENFINGQYHAVSLHRYILFIAVPLALVLGW----RQKRE-------------------- 307 Sporomusa malonica
WP_009035273 249 EMNYSQGlw-nEL-----NIWSLVKMGDHLGALYPHFMIF-----LLFGMLiahFKKKRVs------------------- 298 Indibacter alka...
SDD40947     291 DFTYDFGvw-kDL-----MPWKFFWSGNQSGVHFAPIYLILTLGF-LLFSEfnsLKKKS--------------------- 342
WP_091654428 253 DFSYDFGiw-vNQ-----WPWEFFLSGDQNGVYYSPLYLFIIVCLLIWAKIsnpFYQKG--------------------- 305 Algoriphagus or...
Q2FUN5       259 EFSSIGL----PFIDTFQTGYGMLSSGQYHAESLHQ-LIVPVLWVSLALMVihqLGKKRDinryiiyfgtllsgglilsh 333 Methanospirillu...
WP_021639049 291 TMAEDNF----TAGQIVSSIWEVFYQAIFHAQPSHTRFVLPLCMLFLIYRIfcfLREKKPgk------------------ 348 Clostridia
EOS30609     244 TMAEADL----TAGEIMAQSADVWLHGMFHAESVHDKLVLWICAGYFFWRNgkyVAERKYka------------------ 301
WP_175475101 249 TMKDASM----GFSQIMGECAAVFTSGMMHADDAHRFLVLPICTVYFVFLNvryILRRDFkg------------------ 306 Butyrivibrio sp...
EOS74357     246 TMQEGSF----TAKEIIKTIGDVFVNGMFHAESMHKYLIMPACMIYFIYLNltyIKKKEFkg------------------ 303

WP_092045373 328 ---------------------------------------ivHDYFNFCAVAIAFNSIIYGLYFFAP-IRKLfELLIPPLK 367 Butyrivibrio sp...
WP_084577509 308 -----------------------------------------CKLIVLLLALALCLSVFYGLRYSELfMTTV--AGISFFN 344 Sporomusa malonica
WP_009035273 299 -----------------------------------------PYVLTFVFTFLSLVILVWAVSNLVG-MDWI-GRQIPVLK 335 Indibacter alka...
SDD40947     343 ---------------------------------------------LRDLLFVLGIGLGLSVISHSSiMTFA-GQFLPSLA 376
WP_091654428 306 ---------------------------------------------LRFFLMFLSLSILLAILSSSGlLAVL-GKWIPVLA 339 Algoriphagus or...
Q2FUN5       334 ltsrvngdlitlflwssiifflflllglhlkgvskgkfltiEWIIVGLTTLVFLFSFIYQVSTLDL-FLFI-KSQFFVLN 411 Methanospirillu...
WP_021639049 349 ---------------------------------------ivTDSFCLVIYFIIGNCLVYGFYYWGG-FRRLfETLVPPLK 388 Clostridia
EOS30609     302 ---------------------------------------ifHDVYNLLMLLLVFNSVVYGIYNWGA-FRRMvEMLVPPLK 341
WP_175475101 307 ---------------------------------------mvHDIYNLFAVLLVFNSLIYGLYYSEG-MRNFvAFLLPPLT 346 Butyrivibrio sp...
EOS74357     304 ---------------------------------------ifHDLYNLLMLVLVFNSVVYGIYYWEG-FRRViETICPPLT 343

WP_092045373 368 GWQFNRTIFFNPFLWYASFMIVCYRICKSTRQNsvsqrrgfwfRGLVYLMVLASIAVIIIQPALPYGQDaRyddiyytay 447 Butyrivibrio sp...
WP_084577509 345 TFQIQRFHWLHPLLWYTIFALSLTVIANIRYIG----------RLLAALILVLQLGYLFGNNIEYQLVIkEqtgvsvme- 413 Sporomusa malonica
WP_009035273 336 SINLMRFNHIFPFLIMGILGVIFTRMRLHYL------------KIMSITIIAVNI---LVYHYEWRYwlgnqt------- 393 Indibacter alka...
SDD40947     377 SLNFLRFEFWIPYFLFAAFFRAWASINFKWA------------NFLIPSLLLVNI---FIYQYEWRYwlnqdl------- 434
WP_091654428 340 SFNLLRFEYWIPFLLFASLFFLWRSKAFAGF------------RVLLPLLLLMNI---FVYQYEWRYwindyf------- 397 Algoriphagus or...
Q2FUN5       412 ALQM-RFYTLLPVIWYLIFGICSIYILERSKKL----------KIFVYGVILIQIIFLFSFQGGTyqtggy--------- 471 Methanospirillu...
WP_021639049 389 GFQFNRTVFFNPFLWYAALFLLVKYLIdk------------rkQWLGYLVSLIALAVVILTPa-------Vyndfystcy 449 Clostridia
EOS30609     342 GFQFNRTVFFSPFLWYGAYFMILQRMYTFSFGTegreairrwsRWAANGLALAAAAVILLTPs-------Ryndlfftck 414
WP_175475101 347 GWQFNRTIFFSPFIWYASLFVVCIRMArken---------vvfRIAARVIPIAAVFVILLCSe-------Hyndvydtay 410 Butyrivibrio sp...
EOS74357     344 GWQFNRTIFFSPFIWYAAFFLVLKRLYdsqr---------ksmKIFADVLALFAVCIIVLSGt-------Ryndlyhtcy 407

WP_092045373 448 geyykhnhdgktpdNNLSLEEFYDPQLFGTLKEEIGYIEGEQ-CAAYLMYPAQLEYNDISTLDGYLGFYSQDYKDKWRNV 526 Butyrivibrio sp...
WP_084577509 414 ---------nawlyenISYGEFFADSLLKQVDHYIGQPKQEYrVASIGLYPAITQYNGFYTLDGRLNIYPLEYKHAFRQI 484 Sporomusa malonica
WP_009035273 394 ---------gfiefRAPSYQEYYAKEQYDEIKEFIGKDYPFKlIGHINLPPAVSIYHGFRSVDGYLQNYDVAHKHKVGEV 464 Indibacter alka...
SDD40947     435 ---------klinqQVPSFKAYYSEDSYEEIKNFLGEDWQHVrIAHLNVPPASSAYNGLLCLDGYMQNYRREHKMQVFQV 505
WP_091654428 398 ---------pllsqKVLSYQEYYSEKEFGELKEFIGEDVSSKrFLHFNIPPAVSAYNGLISLDGYLQVYDRKHKMEVFEV 468 Algoriphagus or...
Q2FUN5       472 ---------gnlqdGQYSFNEFYSPDVFESIRDEIGINQSSYrVGSIGIHPAISQYNGFYTVDGYFANYLLQYKHQFREI 542 Methanospirillu...
WP_021639049 450 yn--ayriikhtqvENLNYREFYSQKLFEEIKADIGY-DGEY-SAAYGMHPAVLSYNGIATLDGYLGFYPQEYKEEFGAM 525 Clostridia
EOS30609     415 nk--aleiikgkeiDEMNFREFYSCDLFEKVKEDIGY-EGEW-SAAYGFHPAVLEYNGIATLDGYLGFYPQSYKEDFRRI 490
WP_175475101 411 gt--ayriktgqevDRLSYREFYSSRLFDKIKGDIGYDESQW-AVAYGMHPAVLEYNGISTLDGYLGFYSQEYKEKFRKV 487 Butyrivibrio sp...
EOS74357     408 sq--ayhllkgkttDQLSYGEFYSAELFEEAKQDLGY-KGEW-SAAYGFYPATLEYNGISTLDGYLGFYSQEYKEAFRRI 483

WP_092045373 527 IAPALDLQPASADYFDNSGIRCYLYSGDHVSVPMYTKDLGgITQDNLYINNVALAA-LGCKYIFSRVEITNAHEIGLELI 605 Butyrivibrio sp...
WP_084577509 485 MAKELDKNPFWQRYFDNWGITCYLFPAELE-YYQVRRSYQ-LKLTSMELDIAAFKK-LGGQYILSAAEITNYRENGLDFL 561 Sporomusa malonica
WP_009035273 465 IENEIKRDEFLYSHFFDWGNKCYLLNTTYPDNYTAYKWQKfEAIEKLEFDFIKLKNdLGVSLIFSAIPVDVTQ---LQML 541 Indibacter alka...
SDD40947     506 IRDELAKDESLDKHFMNWGNKCYFQNAQYPDDYFMYAWREeEKIRELQFDFDFLRDsLKAEYIISALPVESSA---LNLE 582
WP_091654428 469 IQDELAKDNSLRRHFYNWGNKCYFQNAQFPDDYFMYKWREeDVLIEPDYDYVYLKEvLKADYILSALPVSSSN---FKLL 545 Algoriphagus or...
Q2FUN5       543 IAPELNKSERWRVYFDGWGSRAYIFSSELD-GTSYSKGNG-IVLQDLDLNITAFKN-LGGKYIFSAVEIDPVVK-GLSLE 618 Methanospirillu...
WP_021639049 526 IAPATQKVEEWNTYFWDWGARAYLYSGSGENTWNAVRTMA-TADDRLYIDGDMFRR-LGGKYLFSRIKISNEKELGFTLT 603 Clostridia
EOS30609     491 IAPALERVEASRAYYDDWGARAYLYSGTDLSVVSQFKSFT-VEDKDIYIDAGAFAD-LGGKYIFSRFELGNADEAGLHLI 568
WP_175475101 488 IAPALDRKENTRIYFDDWGARCYLYSGTDDSIVMATRSYTgVTDTDIYIDTKALSE-LNCKYIFSRIEIGNASEKGLYLE 566 Butyrivibrio sp...
EOS74357     484 IAPALERVEESRIYFDDWGARAYLYSGTDLSIVNGFRTYQ-VQEQDIYINVDAFQA-LGGEFIFSRVKLTNAREAGLLHA 561

WP_092045373 606 T--SKQGIAYKVYVYKLS 621 Butyrivibrio sp. TB
WP_084577509 562 QrfTEPWSPWEIYLYQAR 579 Sporomusa malonica
WP_009035273 542 RkfEHSNSAWDIYVYEID 559 Indibacter alkaliphilus
SDD40947     583 LrvENPESAWKLHVYSIK 600
WP_091654428 546 KvfEGTHSAWRIHLYELD 563 Algoriphagus ornithinivorans
Q2FUN5       619 GvySSEKSPWEIRVYSVQ 636 Methanospirillum hungatei JF-1
WP_021639049 604 GtyTQEESPYTIYVYDAG 621 Clostridia
EOS30609     569 KayEAEEAPYAVYVYCCG 586
WP_175475101 567 GtyEDPSSPYIIYVYGLE 584 Butyrivibrio sp. ob235
EOS74357     562 GtyTHESSPYTLYVYQVQ 579
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