Conserved Protein Domain Family
DUF6039
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pfam19505: DUF6039 (This model is not part of the current CDD release)
Family of unknown function (DUF6039)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001101) is described by MIBiG as an example of the following biosynthetic classes, NRP and Polyketide (Macrolide). This family includes a protein from the leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus and appears to be predominantly found in Actinobacteria.
Links
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Statistics
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PSSM-Id: 523701
Aligned: 16 rows
Threshold Bit Score: 454.484
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
RCG27060       1 MMTNPSPVIPPAEQQTSVA--AADLLNSANAGVIVERTAQVRNGFHAEGRKFARMMAEFVTAKQVGVASAYVYEETFGTK 78 
WP_100570190   3 EKADSEFSTPVAQQQTSLP--VADILHSANAGVVVERVGQLRAEFRSEGRQFARELSEYLNTRYVGVATTFVYEETFGTK 80  unclassified St...
EWC61509       3 MTDIIERPVLAETDETGVPaqAPTAFNTSNSGFVIHRSGQIRHEFRREGREFALELAGFLNKPLAGKATIVVFEELFGQQ 82 
WP_100596215   4 AASQAQGAFLPAHSGPLGS--GSDLLHSGNAGFIIHRAGQLNHAFRAQGRQFATDLVGHLNKVVEGVATIVVHEEILGTA 81  unclassified St...
WP_073890570   4 RTARRTAGLSPASAQSPVP--ADKLLHSGNSGFTIARSAQLKYEHRDEGRKLFASVIAYMNQSDLNGASFYFYEEAFGKQ 81  Streptomyces
WP_073388678   5 TDTAPQTTIPCAHMQTSLT--PDKLINSANAGLIIHRVGQFKYEFSDEGHGFSVDLLNYINENQLGTATTFCYEETFGVR 82  Jatrophihabitan...
WP_097318952   1 MTATTAAATPRAQDQTSLA--PEKLLHSGNSGMVIYRVGQLNYEFAREGRGFSVDLLGYINDKQQGVATTFCYEEVFGVK 78  Paractinoplanes...
WP_012786805  23 TSPTATAPIVQAQQQTGLP--PEQLLHSGNAGMIIYRVGQLEYEFAREGRGYSVDLLKYVNDNQVGIATTFAYEEVFGVR 100 Catenulispora a...
WP_114031843   1 MTDTDAWSPRSAQYQTTLP--PERLLHSGNAGIVIHRTGQLEYEMAAEGRDFSVELVNYMNRAQVDVATTFLYEEVFGVR 78  Sphaerisporangi...
2_pfamImport   1 PY--------RALNQSSLP--LERVLHTLNSGFILHRVGQMAYGFAAEGRQFSVDLLQYINTSQEGVATSFAFEEVFGGR 70 

RCG27060      79 DRLHWLIHLSSLDAYEAMVHMGTSDEEYRGAV---AKPQAGDGGGWDRVFVDGSMHETVLMPQFwgmygtkvdGERERGT 155
WP_100570190  81 DTLHWLLHMRSLEAYETLVRMGSQDEGWREVMfrnRIPEERGGGSWDRMFLDGGLKETVLIPQSfgm---ygtADTELSS 157 unclassified St...
EWC61509      83 DRVHWVQHFKNPNDYHVILDLVDHDKTFKDITerdRL-AEGGGGNWERMFTEGTFSERVIVPQH---------GVGDHDD 152
WP_100596215  82 DRLHWLIHMKQPNDYSRFLEIADHDRSFKEITeadRIAAAEGAGNWERMFVEGSFQERVYVPQH---------GLDEHDD 152 unclassified St...
WP_073890570  82 DRVHWLIHWKTPNDYAISLHMVDHDEKMIDLLesdRVVDDASAGVWGRAVVEGSVQERILVPQH---------GLVHEED 152 Streptomyces
WP_073388678  83 DRVHWLIHMRSADAYKKLLHMVDHDEKFQDISirdRL-PEKGHGNWEKIFIESSMQERILVPQH---------GVNQHHD 152 Jatrophihabitan...
WP_097318952  79 DRLHWLIHMRSPNEYQKLLEMVDHDEEFQGISvvdRL-PEKGHGNWEKIFLESSMYERILCPQH---------GLQHHHD 148 Paractinoplanes...
WP_012786805 101 DRMHWLIHMRSPNQYGELLEMVDHDEKFQDISvvdRL-PEKGHGNWEKMFTPRSFAERILVPQH---------GLHLRHG 170 Catenulispora a...
WP_114031843  79 DRVHWFVHMKSPELYSRLLEMVDHDAAFQDISlrdRL-PKKGGGNWEKMFVYGSLRETIMCPQH---------GFANVGH 148 Sphaerisporangi...
2_pfamImport  71 DRMHWFIHLKSPQDYRILLNMVDHDLEFRRISdedRL-PHKGGGNWDRIFVHRSLHEDVLVPQH---------GMDHDGD 140

RCG27060     156 A---QYTQEGPITGLPGAREQVALPAGQILHSGTCGLLLHRTAQLDYDFRSEGRTFAREAAESINENLPGEATVFVYEEA 232
WP_100570190 158 V---VDDDGVDRFVVPTAEHQTSQKPDELLHSANSGIIMHRTGELKYEFRAEGREFARALTESWNASLGGEATIFLYEEA 234 unclassified St...
EWC61509     153 D------DDDPTYFADPASHQTTVPEGELLHTGNAGITIMRTAHCKYEFRDEARQFAYEWANHINNTLRGSVSAFLFEET 226
WP_100596215 153 Dh--DHHDEPSDTFVPPARHQTGLPDSRMRSSVDSGLTIIRTAQTAFRFRTEAREFAFAWASEVNRALGGELTVYLYEET 230 unclassified St...
WP_073890570 153 D------HDPGELWVDPAKLQTGRPDGELLHSANAMLTLHRTGQATHEFRKEARLYAFAWQNEVNRKLPGRATSYLYEET 226 Streptomyces
WP_073388678 153 D------DDDPDLFAPPAYNQTMQPRDEQLHSGNAGAIVMRAGNVKYEFREEGRIFWWDWQEHVNLALPGRVTSFLYEET 226 Jatrophihabitan...
WP_097318952 149 E---PDDPQEAANFVTSARHQTAQPFGDQLNSSNAGAIVVRTATVKYEFRKEGRLFAFDWQEHVNRELAGDVTVLLYEET 225 Paractinoplanes...
WP_012786805 171 EaegDGDATEAQNFAPSARHQSAQPFDVQLNSANAGAVVLREADVKYEYRKEGRLFGFDWQEYVNRELAGRVTILLYEET 250 Catenulispora a...
WP_114031843 149 DehpTDPRERRESFVPPATHQTTQPPGRQLNSANAGAIVLRTGDVRYEFREEGRRFLYDWSTYVNDALPGQATAFVYEQT 228 Sphaerisporangi...
2_pfamImport 141 D-------AEPATFVPPASSQLNQPPEQQINSATAGAIVMRTSDVKYEFREEGRMYAAHWQHFVNERLAGRVTATLYEQT 213

RCG27060     233 FGAADRIHWLIHLKSLSTYYKVLSLHV-KDERVRELYFQERIAPERGGGTWARMFVPGSMADVALTPHHWGMY 304
WP_100570190 235 FGLSDRIHWFIHLRKLSSYYNLMGLRArTMPAAREVFTKQWIPAEKGGGGWERMFVQSSLQDLALTPQHWGMY 307 unclassified Streptomyces
EWC61509     227 FGRQDRIHWTLHFKTLNDYLKLVELGK--DETYKQILGARRVALAKGGGSWEKTFVDGTIQDLVLSPLRSGTT 297
WP_100596215 231 FGQQDRIHWMIHLDSLDTYRKLTELSR-HDADYQALFGRQFVPDFKGGGGWEQTFVSPTIQDTVLTPLHPGAP 302 unclassified Streptomyces
WP_073890570 227 FGVMDRLHWLVHLKDFDAYQELLELER-TDKDFRALGERQFIADQKGGGTWGRTYVPGTIEDTLLLPHQLTAA 298 Streptomyces
WP_073388678 227 WGRQDRVHCLIHLRDLEDYKAVLELER-DPAFREEVYAKQRVHESKGGGTWEQLFVDGTIDDTLLVPRMPSQH 298 Jatrophihabitans endop...
WP_097318952 226 FGQQDRIYSLIHLRDLDAYGALAELDR-SPATDERIYRKPRVHESKGGGTWERLFVPATIHDTLLLPQRPSTP 297 Paractinoplanes atraur...
WP_012786805 251 FGRQDHIYWLIHLRSLDDWQALADLER-TDGIQKEIYAKPRLHESKGGGTWDQLFVSTSIRDTLMLPYRTSDV 322 Catenulispora acidiphila
WP_114031843 229 WGQQDRIHCLIHLRDLEDYRVVQEVDR-SEGMHKEVYDPERVPAAKGGGRWDRLFVPTSINDVVMVPHFADRP 300 Sphaerisporangium album
2_pfamImport 214 WGQQDHLFQLIHLRSVDDYHELRELER-GKEMATEVFGRRRLHESKGGGTWDRLFIEGSIRDTLLLPQVPSGA 285
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