Conserved Protein Domain Family
DUF6008
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pfam19471: DUF6008 (This model is not part of the current CDD release)
Family of unknown function (DUF6008)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000112) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus subsp. neocarzinostaticus and appears to be restricted to Actinobacteria.
Links
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Statistics
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PSSM-Id: 523696
Aligned: 16 rows
Threshold Bit Score: 249.61
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
SCD28279       1 Mdhsgm----pgmpgMGPTVSTVDTLGAVLFIGWTVAMWVAVAVLAIGNRRAVRPWMYKLAVALIGVGVVSQLGHFQEHV 76 
WP_073901556   1 MdhahgghgmsgmggMGSTVSSMDTVGAVLFIGWAVAMWAAVVVLALGNRGQVRPWLYRTAVGLIGLGVIGQIGHFQEHV 80  Streptomyces
WP_047961335   1 MnhppgmpgmpgmagMGGPVSTLDTVTAVLFILWAVSMWLAVGVLAYANRGPVKPWLYKTSVGLIGLGVIGQIGHFQEHV 80  Streptomyces sp...
KIE25742       1 M---------------GNVVSSWDTLGAVFLIAWAAAMWLAVIVLALANRGPARPWLFKTAVAVIGLGVIGQIGHFQEHV 65 
WP_089302029   1 M---------------GIPTPLWSIAAA-LLVLWAAAMWTAVAVLARANRNPVRPWLYRASAGVIVLGVLGQLGHVQEHI 64  Haloechinothrix...
WP_013226232   1 M---------------AMPMSGWDTAGAVLLVLWALAMWTAVGILAYANRGPVRRWVYRGALAVIGFGVLGQLGHVQEHV 65  Amycolatopsis m...
WP_245992360   1 Me---------------hTASVWDIAGAVAMTALAVAMWAAVAVLAYATRSRVRPWCLRASVGVVAAGVLGQIGHLQEHV 65  Prauserella mur...
WP_219927260   1 M---------------SGSVTVLEVAGAAGLTVYAVAMWVAVGVLAYALRGPLPPWLPRVAAGVITAGVVGQLGHVQEHV 65  Prauserella shu...
WP_009156155   1 Mqh------------sHASATTLEMLGAAGLFLWAVSMWAAVAVLVYAAHRVVRPWLYHGSACVIVVGMFGQIGHVQEHF 68  Saccharomonospo...
WP_014981889   1 Menm----------hhGAGATGWEIAGAIAMLSWMVVMWAAVAVLIVAMRRGVRPWMYRGSLGVIGLGVLAQIGHFQEHV 70  Nocardia brasil...

SCD28279      77 TQAGYWVAHPYAPAWMTPWAESFSRGLGQVDSSKPALGMEILHLTGNFMFLAGLVGVVQITHRVTGElKARKWARMGVWM 156
WP_073901556  81 AQVGYWVAHPYSPAWMTPWANGLSRGMGQVDSSKPMLGMEILHLTGNFIFLAGLVGIAQITRRAAGElKSRKWAKMGVWM 160 Streptomyces
WP_047961335  81 SQAVYWIAHPTSPAWMTPWANSLSRGMGQVDTTKPSLGMEILHLTGNFIFLAGLVGIVLITKRVAGQlQSRKWAKMGVWM 160 Streptomyces sp...
KIE25742      66 AQTGYWVAHPYSPAWMTPWGNGLARGMGQVDPSKPTLGMEILHLTGNFIFLAGLVGVMQITRRAVGGlKSRKWAKMGVWM 145
WP_089302029  65 AQVAYWTAHPNSPAWMTPWGDGLAAALGRVNPAEPSLGMEILHLTGNVVFLAGLAGIMLITRHALRS-RSRTWARMGVWM 143 Haloechinothrix...
WP_013226232  66 AQAGYWLGHPNAPAWMTPWGTGLASGLQQVLPGRPTFGMELLHLTGNFLFLAGLAGVMVITRRATNT-RTRRWAKMGVWM 144 Amycolatopsis m...
WP_245992360  66 AQAGYWVLNPERPPWMTPWGDALARGFGIVDPATHSLGMEILHLVGNSVFLAGLAGIVLVTRYAAGS-RARRWARMGVWM 144 Prauserella mur...
WP_219927260  66 AQAAYWVLHPEEPAWMTPWGDGLARGFHALAGGQHALGMELLHLTGNVVFLAGLVGVALVARHAAAF-RARRWARMGVWM 144 Prauserella shu...
WP_009156155  69 AQVGYWAANPNERAWMTPWGTGLADGFGALVSGSPTLGMEILHLVGNFIFLAGLVGVVLITREAVHS-KARKWGRMGAVM 147 Saccharomonospo...
WP_014981889  71 LQVGYWLGHPNSPAWMTPWGTGLANGFGQVDTSKPTLGMEILHLAGNFQFLAGLVGVALITHRALAS-KARKWGRMGVLM 149 Nocardia brasil...

SCD28279     157 QGIHGLEHVALTLSVALGASRAIGLSTWFGAIEPGPALVTYRVWWHFVANLVGTFILVTAVYHLWKEKRRVRESFglgep 236
WP_073901556 161 QTIHGIEHVALTLSVALGASRAIGLSTWFGLIEPGPALVTYRVWWHFVANLIGTAILAIAVYHLWKERRAVKAGYgapva 240 Streptomyces
WP_047961335 161 QGIHGLEHVVLTASVALGAKRAIGLSTWFGTIDPGPALTTYRVWWHFVANLIGTGILALSLYHLWREKRSVKAGFgertg 240 Streptomyces sp...
KIE25742     146 QGMHGLEHLVLTLSVALGASRAIGLSTWFGLIEPGPALVTYRVWWHFIANLVGSVIFAVSLYHLWKERHAVKAGYqasgv 225
WP_089302029 144 QGIHGVEHLALTLSVALGAGRAIGLSTWFGLLDPGPGLWTYRIWWHFIANIVGTVIFGIALYHLWRERREVEAAYr---- 219 Haloechinothrix...
WP_013226232 145 QGLHGLEHLVLTLSVAFGAPRAIGLSTFFGLVDPGPGLTTYRVWWHFAANIAGSIIFGLALYHLWRERREVRATF----- 219 Amycolatopsis m...
WP_245992360 145 QGLHGLEHLVLTVSVAIGQQ-AVGLSTWFGTLPAGPALWTYRVWWHFVANVVGSVIFAIALHHAWRERRLVTASWsa--- 220 Prauserella mur...
WP_219927260 145 QGLHGLEHLVLTVSVALGGP-AVGLSTWFGTIEPGPALWTYRIWWHFLANVAGSIVLTVALCLLWAERDRVAGSWsga-- 221 Prauserella shu...
WP_009156155 148 QGIHGLEHLALTVSVAAGSP-AIGISTLFGLLEPGPGLWTYRIWWHLIANVVGTVIFVVACHHLWKERRGVAASFsp--- 223 Saccharomonospo...
WP_014981889 150 QGIHGLEHIALTVSVALGAK-AIGLSTWFGLLDPGPGLWTYRVWWHFGANVVGTTIFVLALIHLWRERATIEATFr---- 224 Nocardia brasil...

SCD28279     237 evvaatpdaseplsphgeddpapadddlsraenepprvdapahadgspraeddaahaDDPSRVLAPAKHL 306
WP_073901556 241 epseagvtva--------------------------------vvdsadadqadagseESPAAEPTLAGRS 278 Streptomyces
WP_047961335 241 deasqtpgdgetpa------------------------hgepcptchtttgtsstvgSAADSELVGAGRA 286 Streptomyces sp. Mg1
KIE25742     226 eesvfvp---------------------------------------ssvstslpaseEEAAPGHDLVGRA 256
WP_089302029 220 ---------------------------------------------------------TPAGPASAVPGRR 232 Haloechinothrix alba
WP_013226232 220 ----------------------------------------------------------VLRPLPAVTGRA 231 Amycolatopsis mediterranei
WP_245992360 221 -------------------------------------------------------atPGPRVEPDPADRA 235 Prauserella muralis
WP_219927260 222 -------------------------------------------------------rrVTPQRAPVHSNAG 236 Prauserella shujinwangii
WP_009156155 224 --------------------------------------------------------rVPQPRAPERTAES 237 Saccharomonospora marina
WP_014981889 225 ---------------------------------------------------------TPSERSATIAETP 237 Nocardia brasiliensis
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