Conserved Protein Domain Family
CRIM1_C
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pfam19442: CRIM1_C (This model is not part of the current CDD release)
Cysteine-rich motor neuron 1 protein C-terminal
Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.
Links
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Statistics
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PSSM-Id: 523681
Aligned: 7 rows
Threshold Bit Score: 251.325
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014066561  896 ENDIMPQFKgNFGSLQMPFLDGKTPVPREDTTLHSVAWVALPIIMMLFTITALLFINQKKQWIPVLC-YRTPTKPTCLNN 974 
NP_001163917  900 ENDIVHHHR-DMGHLQANYREVERPRLTEEDSLHSVAWVAVPIMIALVILIVLFMINQKKQWIPVPC-YRTPNKPTCLNN 977 
XP_028906771  893 ENEIGHLPR-DMAHLQVGYRD-SEPHLNEDTSFDSVAWVTVPVVIALILIIALLLINRKKQWIPVPC-YRTPTKPSCLNN 969 
XP_007521065  907 ENDIIHGPR-DMGHLQVDPRE-SRPRPSEDSSVDPITWVVLSVTMFGIVIIVFLFINQRRQWVPLHCwYPTPTKPSSLNN 984 
XP_047300600  775 ENDIVHLPR-DMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNN 852  human
XP_046794361  838 ENDIIHIHR-DMNHLQGEYRSGNGPHPSEDASVSSVALVTVPITIALLVIIVFLLINQKKQWIPVSC-YKAPTKPSCLNN 915  chicken
XP_005989783  901 ENEIASQRR-GMSNLQVDYRESNGPLPNDESPLHSIAWVTVPVMTALVLIIALLLVNQKKQWIPVPC-YRAPTKPTCLNN 978  coelacanth

XP_014066561  975 QLVYVDCQKGTKVQVDSSQCMIRIADPDSRYSGYYSMqkqNNLNNLQADNFYQTQ 1029
NP_001163917  978 QLVYVDCKKGTMVQVDSSQRMLRMADPDSRYSGFYSM---QKQNNLQADNFYQTV 1029
XP_028906771  970 QLVYVDCKKGTMVQVDSSQRMLRIADPDARFSGFYSM---QKQNNLQADNFYQTV 1021
XP_007521065  985 QLVSVDCKKGNRAQADSSQRMLRMAEPDARFSGLYSM---QKQNHLQADNFYQTV 1036
XP_047300600  853 QLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSM---QKQNHLQADNFYQTv 904  human
XP_046794361  916 QLVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSM---QKQNNLQADNFYQTV 967  chicken
XP_005989783  979 QLVYVDCKKGTMVPVDSSQRMLRMADPDSRYSGFYSM---QKQNNLQADNFYQTV 1030 coelacanth
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