Conserved Protein Domain Family
LIN9_C

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pfam19438: LIN9_C 
LIN9 C-terminal
MuvB transcriptional regulatory complex interacts with B-Myb to form the MMB complex during S-phase of the cell cycle to activate genes required for the G2 and M phases. This is a domain found at the C-terminal of LIN9, one of the core members of the MuvB complex that functions as a scaffold protein and forms a subcomplex with the C-terminal of LIN152. This subcomplex forms a binding interface that recruits B-Myb to the MuvB complex which is arranged as a three-stranded antiparallel coiled-coil as the core of the structure. LIN9 contributes two helices (alpha1 and alpha2) that run antiparallel and are connected through a short linker.
Statistics
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PSSM-Id: 498024
Aligned: 25 rows
Threshold Bit Score: 291.488
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
RUS74508      254 PDYEVWSEDQPDTIRISSFQEKQTRQmfvnkqATlAPPQI----PK---------------------------------F 296 
RWS30925      177 PDYEVLSTDPPEFIPLSSFQTKVRPR-------L-PLIPS----PRfl------------------------------eL 214 
ROT80589      823 PDYEVL-------LEPGSVGA---DS------------------P----------------------------------- 839 
XP_046448791  388 PDYEVLSNETVDMISISSLAQRFRPR------PA--VLPPt---PAiiplmasqqqtltissqhqqpikqsslevamptL 456 
3_pfamImport    1 LDYEVCSNQPPETISKNVLLQMCRPR-------I----------P----------------------------------Y 29  
XP_017297905  315 PDYEVLSNDTPETLNRQSFLQ-----------MF--FASV----PNd--------------------------------H 345 
XP_002433129  385 PDYEVLSNEEPDMFSLSTFNK--------------RFHNQ----Pr---------------------------------Y 413 
5_pfamImport    1 PDYEVLSNESPETLSILSFQSKFRPRl-----NG-FPPYSsdknPN---------------------------------Y 41  
XP_008192169  306 PDYEVLSNEPPETLSLSSFQNKFRPWn-----GI-TTYAAk--iSP---------------------------------Y 344 
1_pfamImport    1 PDYEVLSNEPPDTISLSSITKKFRPR-------F--VLQDi---fNl--------------------------------Y 36  
RUS74508      297 --VPGF------Ls----pSPGThsvgdvsirTSTSMAAG-MsaveqpsP-FKG--KLVSL------EGGTYGGFPIKFL 354 
RWS30925      215 l-GNQV------A------QALG---------DSDPLQSVaS-------P--CK--TEPGTvssnlqDEGTLGGFPIKFL 261 
ROT80589      840 ----AL------S--------LT----------NDPILAQ-S-------PlKSS--KISMD--------DTLGGFPVRCL 873 
XP_046448791  457 slTSHVsgtrigHtshsdsSSLV----------SDPVLGS-S----------NS--RLTPQ-------ETTFGSLPIHVL 506 
3_pfamImport   30 h-NRSI-------------SPET----------KVDLLKT---------------------------DQNTIAQYSMKLL 58  
XP_017297905  346 --TNRT------G------KPEP-----------EAMDAN-H---------IDK--ELEGM----------LGEYPVELL 378 
XP_002433129  414 -----L------P------STRS---------QLIEIKSE-Akv---daS--------RSS----------LGQFPLAFL 445 
5_pfamImport   42 ---KTL---------------PF---------SRDPLLSG-S-------IvNSPmlIPTAK-------EGKLGQFPVKLL 79  
XP_008192169  345 ---TNL---------------KF---------KKDPLLSG-S-------MiNKP--IFPQE-------EGRIGGYPTKLL 380 
1_pfamImport   37 ---EPT-------------NNNS---------QGDPLIGC-S-----------D---IAKQ-------IDTIGSYPFALL 69  
RUS74508      355 VLVTRLSKILKVKKDWIDQLSAMNTTAEKRNSFQEPITLEFQKTYAGIVLELEKLNKDLNEYLNGVQTYCLDI--VPELG 432 
RWS30925      262 ALLVRLSKILAVKKKMIYELKQMNTEAEKLLGLQEPISYEFQKQYASIILELDKLNTDLNDYLKAIQQYSAEI--APDQG 339 
ROT80589      874 VQIVQLSKILRAKREKIGALRDMNAQAEKQRSYSQELNVDFQRRYAALVLDIEKLNRDLNQHLVVVQQFCQEI--APEQG 951 
XP_046448791  507 TPIVRLSKILNMKKDKVRRLRDMNTEVERRESVGETVAPDFQRRYARTILDLEELNTELNSLLVKVRQQCHEIapDSEHG 586 
3_pfamImport   59 ESTVKFRKILTAKKQYVQTLRNMNSEAERMVLYNEDITPEFQSRYAKIVLDLDNLNLHLTSVMCVLSEEIKVL--APEEA 136 
XP_017297905  379 EQVVRFKKLLKFKKTEVYQIRDMNSEAERRQLYGEPYDRAFQKKYAGHILRLEKINKDVNTVLASLSVNLKKLs-VTSEN 457 
XP_002433129  446 EMIVTISKILTDKKKMVQKLKELNAEAERRTSYGQDFTEDFQRRYATLVIELEFLNKHLERYLASVQKYCHEI--APEQS 523 
5_pfamImport   80 ENMVLVTKILNAKKTCVQQLKTMNSEAEKLNSFDETLSDNFERKYAHILLDLEKLNSDLQVYLDEMQACCQEI--APEAS 157 
XP_008192169  381 EKMVLITKILSVKRTKISELKGMNAKAEKFNSFHSEIPEEFQRNYACILIDLEKLNHDLQLYLDDVQALCQEI--APEPS 458 
1_pfamImport   70 ELIVKLRRILNAKRDKINLLKEYNCDAEKRKSFGQKMPEDFERKYAAVVIELEKMNMDLQDYINDVQQYCQQI--APEPS 147 
RUS74508      433 VVPAEPP---SEIKRKCDEEASKSVARIcrDMLQ---NRRTSNNDRVLKLVSDLTSIMLQIK-TFSENENSSFEFGSLQE 505 
RWS30925      340 LTPIAQP---DFVRQKFFAEAKEIVERS--L------GNSAVKCEKVIDLISQLLSLMLHLR-SFADADISSYELKSLFD 407 
ROT80589      952 LPGPTLLp--GQIRERCYEEAATIVDVT--NHSS---GSPQVSSPAILDLITKLTSLMLQMK-NLTETEVSAYELTSLQE 1023
XP_046448791  587 LSPLAGP---DSIRQLCYQEARDLVETQl-DTRSg--SHPNVTSAPIIALVTGLTSLMLQIKcLAE-SERNAYELQALHD 659 
3_pfamImport  137 ETWPLIT---DYLQNQSFDEAEQMIEHN--KEVTd--SRFMSDDQPMLALIKDLLALMLQVK-TLTENEPTAYELDALKR 208 
XP_017297905  458 MSSQLYAlspSDLQQETYIAAQEIVDTV--NKKN---GNKIVDDQPVVSLITDLTALVLQIK-TLSHSSRSAYEVEVLNK 531 
XP_002433129  524 SIAMLTP---SYLRDKSNGEARALVDNY--FHQPd--KEP-IRNKFLIELVTDLVALMIQVK-SLSDSDQNAHELTVLKQ 594 
5_pfamImport  158 VAAMLTP---SLLREKCKEEAKEIVARH--NSVNmtdKGPc-RNPRVLDLINDLTALMLQIK-NLADNDHSPYELQVLEG 230 
XP_008192169  459 VAAMLAP---SHLREKCREEAAEIVQRQ--NSIIsadKDP-VKNKSILELITDLTALMLQVK-SLADSDQNAYELQVLQG 531 
1_pfamImport  148 LAAMLVP---SHLREICREKASLLVEKN--NNGS-------VKDPNLIDLITDLIALMLQVK-SLSDSDQNAYELTVLQG 214 
RUS74508      506 SLQAIKGGLDANNINVFQNNVEIHINHIQSGLSQMG-NLHAFAASRTK 552 
RWS30925      408 ALQETQKMINSSNVQKFENAVKVPINHIESSLSHLG-NLGAFAESLMD 454 
ROT80589     1024 TLNEIRSSLDESNRVAFQNNIEVHLTHIMSAVSQMG-TLQAFNSHNGT 1070
XP_046448791  660 SLDELRKSLDKSNLTSLRNHVLVHVQHIQSGLCNFD-HMTPFNGTETN 706 
3_pfamImport  209 TMVEIKLKLSQSNQKSFENCVEIHMQQIQSSLDTFH----TLSSSNRK 252 
XP_017297905  532 TMSDIYKKLSPNNQSVFENCIGVHMEQIKAALAGERgSLATLTKPVSQ 579 
XP_002433129  595 SMAHIKRRISPGNQLVFQNSVEIHMQYMESGLGQHG-TLAPFFQQTRP 641 
5_pfamImport  231 TVQNIKKKLSPANQQVFQNCVEVHMKQIEMGLTNIN-LDKLVIGPLGN 277 
XP_008192169  532 TMEQIKRKLTPSNQLVFQNSVEIHMKHIQVGLGQNL-DKKLAINGISK 578 
1_pfamImport  215 TMEQIKMKLEPHHQKLFQNNVEIHMHRIQMGLGQMT-P-NSYVAGSVQ 260 
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