Conserved Protein Domain Family
VCIP135_N

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pfam19437: VCIP135_N (This model is not part of the current CDD release)
VCIP135 N-terminal
Deubiquitinating protein VCIP135 is required for the p97/p47 and p97/p37 pathways during Golgi biogenesis. It reverses ubiquitination events that occurs during mitotic disassembly, regulating Golgi membrane dynamics during mitosis. This entry represents the N-terminal domain of VCIP135 that interacts with the WW domain-containing adaptor with coiled coil (WAC) and increases its deubiquitinating activity, necessary only for p97/p47-mediated Golgi membrane fusion.
Statistics
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PSSM-Id: 523678
Aligned: 15 rows
Threshold Bit Score: 267.296
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007448545   33 APgvlsKRRDR--RILSGSCPDPKCQARLFFPAsGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVtGA 110 
1_pfamImport    1 SP----DTSDKh-HILCGVCPDPQCQTKLHFLS-TSSSVECTGCGQRHDKSTLLSIMEAPTSAGTFQNLLQSLLMST-VK 73  
RUS87369        5 AP----AMRDTv-AVLSGFCPNAPCGKRLYFPE-NEVSVECFGCGQRHTPSTLNNVERLTSNSDFVSS-QKAQMCQAvKK 77  
XP_033607837    3 Av---sGTKMV--PVLVATCPDDGCNAVLIFPS-KDKIVDCHGCGQRHRASEVKDVRQMQEQALGVKNVLRSLLLATnAN 76  
PIK42156        4 QPs---RAQDAapVMLCGTCPDQHCQTKLYFPS-YDVSIECPDCGQRHLRQSLKDIKEVKNPEVAIHNMLRTLLVGN-VT 78  
XP_021345797    5 Sr----QRSEDg-KVLCGSCPDEQCQAKLFFPA-YDKSVECTGCGKRHEQTSLQNIAEVTNPSVALHNILKNILLGN-VK 77  
XP_009051388    6 LSd---KLSDDy-QVLKGRCPDEKCQAQLFFPK-LETSIECTNCGQRHAKSTIQNVEEVKNTEVALHNLLKNVLLGN-IK 79  
XP_013409530    1 MAa---KGNKEpyRVLSGYCPDEGCQTRLFFPA-YETSIECTGCGQRHERNTIKNPEVVTDPEVALHNMLKNVLVEN-TT 75  
EEC04585       19 GPgggrEPAQP--RVLSASCPDEACHSRLFFPS-YDLSVECPQCGQRHDRAALRNVEEVSNPGIAFHSLIRNILVGN-IV 94  
ELT92345        1 MSa---EDRAHl-AVFSGLCPDAQCHTKLFFPA-HDSSIECTGCGQQHQRTVLLDVQEVRNQEVALHHILKNQLVEK-FK 74  
XP_007448545  111 PKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCA-LLGDRAFLIEPEHVNTVGYGKDRSgSL 189 
1_pfamImport   74 PHRGPDNVKVLGLSNYMCKLLSPVLSRYGMDRQTGRAKLLTEMGQGEIFDCG-NLSDRAFLLDSEHVNIEGFGRDPS-SA 151 
RUS87369       78 ENFNHESLKVDGMTNYLCSILSPLLTSHGMDRATGKAKPLTEMGKPAVFDCG-QLCDRAFLIDPAHLNVPSYGRDRSgSR 156 
XP_033607837   77 MKKSADLVKVNGLSNYHCKLLSPLLTYHGMDKNTQKAKPLSELTNKATFDCS-VLSDRSFLISAEHLDILGYGRDQSgSL 155 
PIK42156       79 PKKTTDSVKVLGLSNYHCKLLSPLLTRYGMDKQ-GKAVPLRSLNKGDVFNCA-ILGSRAFLIQPEHIEIMGYGRDMTgSV 156 
XP_021345797   78 PKKGTDDVKVLGLSNYVCKSISPILTRYGMDKRTGKAKLLKELSQQDIFNCGkILGDRAFLIEEENLEVIGYGRDRSgSV 157 
XP_009051388   80 PQKGPENVKVLGLSNYECKLVSFILTTYGMDKTTGKAKLLTDMGQQTVFDCS-LLGDRAFQIDKEHLDVIGYGRDRSgSQ 158 
XP_013409530   76 PKKGTDSVKVLGLSNYHCKLVSPLLTTYGMDKATGEARLLKDMGQKEVFDCS-ILGDRAFLIEQEHIEVYGYGRDRTgST 154 
EEC04585       95 PKHGEDTVKVRGLSNYHCKLVSPLLTTYGMDKRSGKARPLSEMGAGPAFDCG-VLADRAFRIDPELVEVAGYGRDVSgSL 173 
ELT92345       75 PKKGSDSIKFLGVSNYQCKLLSPILTRYGMDKRSGEARLLADMGQGDAFDCK-LLASRAFLIKPEHIEVTGYGRDSTgSM 153 
XP_007448545  190 LYLHDTLEDIKRANK 204 
1_pfamImport  152 AYLADTLEAVKKVND 166 
RUS87369      157 TYLQDTLDQIKLSNE 171 
XP_033607837  156 SYLAETLRRIEEANG 170 
PIK42156      157 EYLKETLEGINRINS 171 
XP_021345797  158 RYLADILKELKIYND 172 
XP_009051388  159 SYLSGILNVIDEINE 173 
XP_013409530  155 KYLADTLEMIRKMNN 169 
EEC04585      174 SYLRGTLALVRAHND 188 
ELT92345      154 GYLEQTLAAVRQSND 168 
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