Conserved Protein Domain Family
DUF5926
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pfam19348: DUF5926 (This model is not part of the current CDD release)
Family of unknown function (DUF5926)
This entry represents a presumed domain that is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 327 amino acids in length. Many proteins in this family are annotated at Topoisomerase II, but the source of this annotation is unclear.
Links
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Statistics
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PSSM-Id: 523641
Aligned: 35 rows
Threshold Bit Score: 316.142
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_013871718  70 PFAGRVDEPDLVALRELVPSATAPLTLAA-GhlqehPEHagRSIVLGTMLPQAVPALVRDNGEILLAMQTGIASDDAGAD 148 Protofrankia
WP_090851993  52 PFEGLPSEPDLVALRELVPAATAPLTLKN-G-------D--RKVLLASLLPMAAPAMVRDSGEVWLGLQVQHAFGDPSRD 121 Nocardioides li...
WP_012814123  55 PFAGLAAETELIALREFLPAASAPLTLIE-------PRAdiPSVTVASVLPGAAAALTRSDRSILLGMQVQTHTGDLSRD 127 Nakamurella mul...
WP_009949285  46 PFEGLAAECELVALREFVPSATAKLPVRE---------G--REVTLATVLPMAAAALMRVDEKAFVGLQVQTRSGDISRD 114 Saccharopolyspora
WP_030427988  53 PFDGLAAECELIALREFVPSATAPLTLKE-Q-------Ge-RTVTLATVLPMAAAALVRSDGEAFVGMQVQTRSGDISAD 123 Allokutzneria a...
WP_073479827  49 PFEGLAAETELIALREFVPSATTPLPLAEpG-------E--REITLATVLPMAAAGLVRADGTALVGLQVQTRSGDVSRD 119 Streptoalloteic...
WP_025353773  50 PFEGLAAEPELIALREFVPSATAALPLAG---------DvpRQVTLATVLPMAAAALVRSDGVAFVGLQVQTRSGDLSRD 120 Kutzneria albida
WP_015097549  47 PFEGLAAETELIALREFVPSATMKLPLKD-A-------G--REVVLASVLPMAAAALIRADGTAFVGLQVQTRSGDLSRD 116 Saccharothrix e...
EWC62855      33 PFEGLAGECELIALREFVPSGTAVLPGAG-A-------D---EITLATVLPMAAAGLVRADGVKFVGLQVQTRSNDISRD 101
WP_075124804  47 PLEGLAGECELIALREFVPSATAPLALAE-------PAE--REITLATVLPMASAALVRADGSALIGLQVQTRSSDVSRD 117 Actinophytocola...

WP_013871718 149 IARALLEALDA---DLGTPVIPRPAAAgsargDGsraaPTLADLLDPAP-LDITVHSGFTWWLP-P-SEdggSPDPQVVA 222 Protofrankia
WP_090851993 122 LAAVLTAALEQaerGESGIVGLTSDPG-----PG----PRLQDLVEGGE-LDITVHEGFEYWVA-D-VE----DQTGMEA 185 Nocardioides li...
WP_012814123 128 LAAALEWALAA---EPSSVLSVIGRAT-----VG----NRYGDLIVDEP-LDVTVYDDFSWWLE---EEi--VPGSEVAL 189 Nakamurella mul...
WP_009949285 115 LARALEWVQSA---EAGTSLPVVGPETa---eAGtv-pNRLQDLVDVDAkLDVELHDDFSWWIPgD-TE----PTGEVAL 182 Saccharopolyspora
WP_030427988 124 LGRSIRWALTA---EPGDVLTVAGDARe---------eARLQDVLAADAgLDVTVHSDFAWWIPgD-DE----PTGEVAL 186 Allokutzneria a...
WP_073479827 120 VARAVRWAMTA---EPGEALPVVGPAG------Pdd-qVRLQDLLDPAAgLDVTLHEDFSWWLPaD-VT----PTGEVAA 184 Streptoalloteic...
WP_025353773 121 VARAIRWALTA---EPGDALPIVGVDN------Gde-pGRLQDLLVADQpLEPVLHEDFAWWLPeD-TQ----ATGDVAL 185 Kutzneria albida
WP_015097549 117 LARAVQWVLTA---ETGDALPVVGPDD------Gtn-pGRLQDLLDADAtVTPELHTDFAWWMPpD-NE----PAGDVAL 181 Saccharothrix e...
EWC62855     102 LARAVLWARDA---EPGDVLAVVGPDTd----AGen-pERLQDLIDATApLEPVVHADFTWWMP-EgSE----PTGEVAL 168
WP_075124804 118 MARALRWALEA---SPGAVLPVVGPETd----ESpe-rERFQDLVDTSApVEPTLHPDFSWWMP-E-GE---EPTGDVAL 184 Actinophytocola...

WP_013871718 223 LLERANAAVVPTARLT--SVDAAYWCRPGERAHLRWVQPYDEEPLLDALTRLAAANSLTVGDESRFVGSLRVDGLVVPVW 300 Protofrankia
WP_090851993 186 ALEQANGSVHPTAKLT--SVPAAYWTNVGTKEHLRWVMPEPENDLLDALSRLHAAGADVLVPESRLVGMFRAHGLLCPVW 263 Nocardioides li...
WP_012814123 190 SLERANAAIMPTARVA--DLPGAYWVDAGERAHLRWVRPEDEPPLMAALARLHVADQLDLGSGSRYVGSFRAHGRLVPVW 267 Nakamurella mul...
WP_009949285 183 SLERANAAIMPTERLNaeGVESAYWVDAGEKAHLRWVRPEPEEKLLAALARLSARGELALGEDSRYAGSFRAHGLLVPVW 262 Saccharopolyspora
WP_030427988 187 SLQRANEAIMPTERVT--GVTAAYWVDAGDKAHIRWVRPEPEEKLLAAMARLSAKGELDLGENTRYAGCFRAHGLLVPVW 264 Allokutzneria a...
WP_073479827 185 SLERANAAIMPTARVDaeGVTAAYWVDAGDKAHLRWVRPEPEERLLAALARLSVRGELGLGENTRYAGSFRAHGLLVPVW 264 Streptoalloteic...
WP_025353773 186 SLERANAAIMPSARLSapGVHAAYWVDAGDKAHLRWVRPEPEEQLLNAMAKLAARNELNLGEGSRYAGSFRAHGLSVPVW 265 Kutzneria albida
WP_015097549 182 SLERANAAILPTERVDapGVHAAYWVDAGDKAHLRWVRPEPEERLLAALARLSVRGELDLGEGSRYAGSFRAHGLLVPVW 261 Saccharothrix e...
EWC62855     169 SLERANGAILPTERIGp----AAYWVDAGEKAHLRWVRPEPEEQLLAALSRLHAAGELALGEGSRYAGSFRAHGLLVPVW 244
WP_075124804 185 SLERANQAIMPTERIG----PAAYWVDAGDRAHLRWVRPEPEEKLLLALARLSARGELGLGEGSRYAGSFRAHGLLVPVW 260 Actinophytocola...

WP_013871718 301 DLAPDADAASCEEAAATLRDQLENAIA--DRTPLTPAERRVRAGVVGRTLTLR 351 Protofrankia
WP_090851993 264 DLPVGTGPEALEEPAEKFATALAEALA--DTSDLTPEQRSARSGLANRQVTIR 314 Nocardioides lianchengensis
WP_012814123 268 DLDRDAHPSEWDEPARAFADRLAAALA--VDEPLTDAERRARDGILGRQFTLR 318 Nakamurella multipartita
WP_009949285 263 DLDREKHAREWEQPAAELGTRLAEALEslDSEPLNAAERRSRDGLRGRQITVR 315 Saccharopolyspora
WP_030427988 265 DIDREMHAKEWEQPVVELGKRLDAALAtiDGEPLTEAERRSRDGLRGRQVTLR 317 Allokutzneria albata
WP_073479827 265 DLDREQHPREWSEPATALGRRLADVLAsvDEEPLDEAERRARDGLRGRQITLR 317 Streptoalloteichus hindustanus
WP_025353773 266 DLDPELHSSEWAAGAEALSTRLTGALAt-ADEQLTDSERRAHDGLRGRQVTLR 317 Kutzneria albida
WP_015097549 262 DLDRELHSSEWASPAEGLSKRLRDALTslDDEPLTEAERRARDGLRGRQITLR 314 Saccharothrix espanaensis
EWC62855     245 DLDRELHAREWTDGATALGERLDAALAsvESTPLTPAERRARDGLLGRQITIR 297
WP_075124804 261 DLDHDSHAREWTEPAAELGTRLEAALEslESEPLTSEERRARDGLIGRQVTIR 313 Actinophytocola xanthii
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