Conserved Protein Domain Family
BAMBI_C
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pfam19337: BAMBI_C 
BMP and activin membrane-bound inhibitor homolog C-terminus
This family represents the C-terminal domain of BMP and activin membrane-bound inhibitor homolog (BAMBI) which contains the transmembrane domain and a short intracellular domain that, unlike all other known TGF-beta type I or type II receptors, does not encode a serine/threonine-kinase domain. However, it shares sequence homology with the E6 and catalytic loops of receptor serine/threonine kinases. BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.
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Statistics
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PSSM-Id: 437169
Aligned: 3 rows
Threshold Bit Score: 249.857
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KPP78838 102 HNGRFQPESNRHLITRVQDLASTKEVWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLRDQRQQMLSRLHYSFHGHh 181
KPP75560 114 VGSRHQSDSSHNLVTKVQELASAKEVWFRAAVIAVPVAGGLILALLVMLALRMLRSENRRLRVHRQHAVAHLHHSFHST- 192
KGL79223  96 QGSRYQHDNNRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHh 175

KPP78838 182 aKKGHVTKLDLECMVPVMGHENCCLTCDKLRQSDSGNDRILSLVHWGMYSGHGKLEFV 239
KPP75560 193 -RKGAPLTKLKPIGTPVGTQDSVCLACDGTRPPDLSRDGILSLVQWGVYNHQGKVELV 249
KGL79223 176 sKKGQVAKLDLECMVPVTGHENCCMTCDKMRHSDLSNDKILSLVHWGMYSGHGKLEFV 233
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