Conserved Protein Domain Family
RNF180_C

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pfam19332: RNF180_C 
E3 ubiquitin-protein ligase RNF180 C-terminus
This family represents the C-terminal region of the E3 ubiquitin-protein ligase RNF180 (Also known as Rines: RING finger protein in neural stem cells) which comprises its transmembrane domain. This is an integral membrane protein located mainly on the cytoplasmic side of the endoplasmic reticulum and functions as an E3 ubiquitin ligase. It is thought that it is involved in modulation of neuronal function, such as regulation of synaptic structure and synaptic plasticity due to its high expression in mature brain.
Statistics
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PSSM-Id: 437164
Aligned: 9 rows
Threshold Bit Score: 118.335
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014352106 482 KTFFPKEYQSRKQSFQKTSCAKWPLPSCRKLFRVFG---G-FSRHRDP-ITRRNFPH-GAYRLDTMDFEDDSRGWRFDMD 555
1_pfamImport   1 KTFFPKEYLSRKQNFQRAPCSKWPLPSCRKLFRIFRgkqG-FQRQTTP-SGRRQFPHgGGFPLDTIDFEDNSRGWRFDMD 78 
XP_027835857 479 KTFFTKEYLKRKQSFQKSSSAKWPLPNCRKAFHLFG---G-FHRRAAP-VTRRQFPH-GAHRMDYLHFEDDSRGWWFDMD 552
KQK76020     221 ESFFPTEYLKLKENFQKSNSAKWPLPSCKKAFRVFE---G-FQRRSDT-VTRRHFPH-AAHRMDYMDFEDDSRVWRFDMD 294
NP_001103874 359 KTCFPKVYRSRHETFQKINYSKWPLPNCPKRFRIFW---G-FQRHGGP-ANRWQFPH-RAFGLDALDW-GDMWGWPFDID 431
XP_013990209 421 KTFFPKVYHSRKHNFQKANCAKWPLPNCRKRFRIFW---G-YQGQVAP-GRWWHFAP-AGFALDALDL-ADMRGWFFDID 493
2_pfamImport   1 AAFFPKVYCARKRNFQNASCAKWSLPSCRKRFRSFW---G-EQRQAA--GRRWHLFH-GGFA----DF-TDVRGWLFYIG 68 
XP_013883802 354 KSLFPRLYSSRKQSFQSASCSRWPLPNAKKPFGWFQ---E--HRRGGArWRRWHLVH-GGFTPGAVYLNDQGS----LTG 423
XP_013858129 391 KTFFPKEYLSRKQNFQRAPCAKWPLPSCRKLFRIFG---AgFQRQASP-GVRRQFPHaGAYPLDDLDFEDDSRGWRFDMD 466
XP_014352106 556 MVIIYIYSVNWVIGFIIFCFLCYFFFS 582
1_pfamImport  79 MVIIYIYSVNWVIGFFIFCFLCYLFFP 105
XP_027835857 553 MVIIYIYSVNWVIGFIVFCFLCYFFFP 579
KQK76020     295 MVIIYIYSVNWVIGFIVFCFLCYFFFP 321
NP_001103874 432 FVIISVYSLHWVMAFIIFCGLCYFLLL 458
XP_013990209 494 LVIIYIHSLNWILALLVLCFLAYFFLS 520
2_pfamImport  69 LVIVHIHSVNWILALLFLFCLLYYYLF 95 
XP_013883802 424 LVLIHPSSDYWILGLKILCVLLILLFS 450
XP_013858129 467 MVIIYIYSINWLIGFFIFCFLCYVFFP 493
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