pfam19307: SrpI-like (This model is not part of the current CDD release)
Type 2A encapsulin shell protein SrpI-like
This entry includes type 2A encapsulin shell protein SrpI from Synechococcus elongatus and its homologues from Mycobacteria, from Mycobacterium leprae, which forms a large 950 kDa complex with itself. It has been described as the most antigenic protein in human leprosy patients, being useful for serodiagnosis of leprosy. Some members of this family contain an N-terminal cyclic nucleotide binding domain pfam00027. This family includes proteins annotated as phage capsid proteins, suggesting that in bacteria this protein is a co-opted phage protein. There is a clear evolutionary relationship between the bacterial encapsulins and Caudovirales bacteriophages as they share the HK97 fold of the capsid proteins.
Jiyao W et al.(2023). "The conserved domain database in 2023.",