5V9X


Conserved Protein Domain Family
WH_Lhr
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pfam19306: WH_Lhr (This model is not part of the current CDD release)
Large helicase-related protein, winged helix domain
This domain is found in Large helicase-related protein from Escherichia coli (Lhr), DEAD/DEAH box helicase from Mycolicibacterium smegmatis and similar prokaryotic sequences. Lhr is a DNA damage-inducible superfamily 2 helicase that uses adenosine triphosphate (ATP) hydrolyzis to drive unidirectional 3' to 5' translocation along single -stranded DNA (ssDNA). These proteins have an N-terminal helicase domain (Lhr-Core) and a C-terminal domain (Lhr-CTD). This entry represents the third domain in the Lhr-Core, which has a winged helix (WH) domain fold. It is found associated to pfam00270 and pfam00271.
Links
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Statistics
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PSSM-Id: 523617
Aligned: 98 rows
Threshold Bit Score: 156.452
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5V9X_A        444 QRMQTGDIETLRVPANPLDVLAQHTVAVAALEPVDADAWFDAVRRSAPFATLPRSAFEATLDLLS-GKYPSTEFAELRPr 522  Mycolicibacte...
WP_125486437  417 RKMRSGELDQLEIPPQPTDVLMQQIVAACGAEPWEEDTLFNTLRRAHPYRDLTREHFDELLELLSnGIESSR--GRYGSy 494  Edaphobacter ...
6_pfamImport    1 DAIRRGEHDTLHVPPMPLDVLAQQVGAETACRDWDEDALYALMRRAWPYAALPRERFDAVLRMLAdGYTTRQ-----GPr 75  
WP_083712818  417 RAMLAGDIEPLHVPRNCLDVLAQQVVACVAMDAWDAPALFDLIRRAYPFSDLSADAFERVLLLVS-GRYPTGSLRDLRAr 495  Paludisphaera...
WP_015244962  425 RAMVDGAVESLRVPNGCLDVLAQQVVACVAMDRWDVPALFDLVRCAYPYTSLTPAAFDSVLRMVA-GRFPTETFRDLRAr 503  Singulisphaer...
Q67R22        388 REMRRGNLEETRVPTGALDVLAQQIVAMAAMDEWRVDDLLALVRRAWGYRDLTERQLHGVLEMLA-GRYPAAEFRELRPr 466  Symbiobacteri...
WP_013019413  419 ERMLDGGIEELRPPSNPIDILSQHLVSMVAMDDWRVDDLARVVRGAAPFASLSDEALRSVLDMVS-GKYPSTGFSGLKPk 497  Stackebrandti...
WP_077025513  432 GAMLDGWVEETKYPRNPLDVLAQQIVAMTCREAIHVDEVFATLRSAAPFFELPHSSFVSILDLLS-GRYPSDEFSELRPr 510  Fuerstiella m...
WP_152097666  463 ERMIRGEVESTRYPRNPLDVLAQQIVAMVAMDPLSVDELYAAVRGAAPFHDLPRSSFEGVLDMLS-GRYPSDEFSELRPr 541  Lacipirellula...
Q1IUR1        424 RAMQDGEVESIRYPRNPLDVLAQQIVAAVAVDPWNVDDLYAFVRGSAPFATLSRPLFDGVLDMLS-GRYPSDEFAELRPr 502  Candidatus Ko...

5V9X_A        523 LVY---DRD-TgtlT--ARPGAQRLAVTSGGAIPDRGMFTVYLAse-teKPSRVGELDEEMVYESRPGDVISLGATSWRI 595  Mycolicibacte...
WP_125486437  495 LLR---DRIhH---QlhPRRGARMIAISNGGAIPDTNLFAVILQp----EGVQIATLDEHFAVDSSPGDVILLGNASWRI 564  Edaphobacter ...
6_pfamImport   76 GAYlhrDAVhH---QlrERRGARMTALTSGGTIPETGDYTVMLEp----QSDRIGTVNEDFAVESLAGDIFQLGNTSYRI 148 
WP_083712818  496 IVW---DRVhN---RlaSLPGSARLALVGGGTIPDLGHYPVYLGe----GGPRLGELDEEFVFERRVGESFMLGNSTWRI 565  Paludisphaera...
WP_015244962  504 VSW---DRVhN---RlhALPGSARLAVTSGGTIPDTGQYPVYLGn----EGPRLGELDEEFVLERRVGETFVLGTATWRI 573  Singulisphaer...
Q67R22        467 IVW---DREvG---VirGREGARALAVLSGGTIPDRGYYTVYLEgs----dvKLGELDEEFVYESRVGDVFLLGSATWQI 536  Symbiobacteri...
WP_013019413  498 LVW---NRAtG---RltARPGAQRLAVLNAGTIPDRGLYGVYLAeg--gTGSRVGELDEEMIYESRVGDVFLLGATSWRI 569  Stackebrandti...
WP_077025513  511 INW---DRItG---MisPRKGAQRLAILNGGTIPDRGLYGVFLVgndgeSGGRVGELDEEMVFECRPGDVFLLGASSWRV 584  Fuerstiella m...
WP_152097666  542 ITW---DRLsG---QltPRKSSQRLAVLNGGTIPDRGLYGVYLAgdagsGGTRVGELDEEMVFETHAGDIFLLGASSWRV 615  Lacipirellula...
Q1IUR1        503 INW---DRVqN---TltPRQGSKSMAIANGGTIPDRGLYGVFLSga-ekKGGRLGELDEEMVFESRPGETIILGATTWRI 575  Candidatus Ko...

5V9X_A        596 TEITH-DRVLVIPAPGQPARL 615  Mycolicibacterium smegmatis
WP_125486437  565 QRIEAiGRVLVEDAHGAPPSL 585  Edaphobacter aggregans
6_pfamImport  149 LRIEP-GRVRVEDAKGAPPNI 168 
WP_083712818  566 DSIDV-HRMIVSPAQGQQAVM 585  Paludisphaera borealis
WP_015244962  574 EAIEA-HRVVVARASGQAAMM 593  Singulisphaera acidiphila
Q67R22        537 RAIEH-DRVVAAPAPGRMPRM 556  Symbiobacterium thermophilum
WP_013019413  570 ESITP-DRVLVSPAPGQAARM 589  Stackebrandtia nassauensis
WP_077025513  585 MDITR-DRVMVVPAPGEPGRM 604  Fuerstiella marisgermanici
WP_152097666  616 LEITR-DRVLVAPAPGEPGKM 635  Lacipirellula parvula
Q1IUR1        576 DDITH-DRVLVSPAPGEPGKM 595  Candidatus Koribacter versatilis Ellin345
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