Conserved Protein Domain Family
PGDH_inter
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pfam19304: PGDH_inter 
D-3-phosphoglycerate dehydrogenase intervening domain
This domain is found in the D-3-phosphoglycerate dehydrogenase enzyme. In the structure of the Mycobacterium tuberculosis enzyme this domain was described as the intervening domain, also known as the allosteric substrate binding domain (ASB). The intervening domain between the substrate-binding and regulatory domains is not present in E. coli PGDH. This domain is closely related to pfam03315. It serves as an anion-binding site and may function as an allosteric site for the control of enzyme activity.
Links
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Statistics
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PSSM-Id: 497914
Aligned: 171 rows
Threshold Bit Score: 115.185
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q67TJ9       322 VVTDHLPLAETLGSFLAQAFPGHADRITVAYSGELAKHPTALLTNTVLKGYLATQLgEHVNYINAPALARRRGIAVNESK 401 Symbiobacterium...
WP_021232846 325 KLKPYMKLAEMLGSMVGQLTRDSVPRISIHVEGAAAELNQKPITAAVLAGFMRVQS-DTVNMVNAPFLAKERGLEVREVK 403 Novosphingobium...
WP_056531985 323 KLKPYMALAEKLGSLVGQLTTGSIGRISIHAEGAAAELNQKPLVQAVLAGFLRTQT-DTANMVNAPVLARERGIEVREVR 401 Sphingomonas sp...
WP_066710936 323 KLRPYMGLAEKLGSLVGQLSHGAIDRISIHREGAAADLNPKPITSAVLTGFLGTQT-ATVNMVNAPVLARDRGVEVREIR 401 Sphingomonas
WP_093665229 323 KLKPYMALAEKLGGLVGQLATGAITAISVEAEGAAAMLNQKPITSAVLAGFLQTQT-ATVNMVNAPLLAKDRGIAVREVR 401 Sphingomonas ge...
WP_039093593 325 RLKPYMALAQQLGSLVGQLAHGDLPSVSVETEGAAAQLNQKPIVGAVLAGLMQRFS-QSVNMVNAPFLARERGIEVREIR 403 Croceibacterium...
WP_047820047 325 KLKPYMALAEKLGSLVGQLAHGNLTRIGIEVEGHAATLNIKPITGAVLSGLMRRYS-DTVNMVNAPFLAKERGMEVREIR 403 Croceicoccus na...
EDL48232     335 KLRPYMKLAENLGSLVGQLAHGNLTKINIEREGAAAELSGKPIEGAVLSGLMRQYS-DTVNMVNAPFLAKERGLDIRSIR 413
5_pfamImport   1 KLKPYMKLAEQLGSFAGQLAETGLRGVTVEYSGQVATLNTRPITAALLTGLLRPLL-DSVNMVNAPIVAKERNISVTEVR 79 
WP_094407447 323 RLTPYIRLAEQLGSLAGQLLTSGVTAVTVEFHGEASALNTRPITAAALTGLLKPAL-DRVNIVSAPVVAKERNIQIAELT 401 Elstera cyanoba...

Q67TJ9       402 SLTHaplgenGtlsPASSLITVRSEGPQGAHEVTGMLRRDGGMRFVAVD 450 Symbiobacterium thermophilum
WP_021232846 404 TERE------G---DYHTLVRVSVKTEAGERSVAGTLFNNVEPRLVELF 443 Novosphingobium lindaniclasticum
WP_056531985 402 TERE------G---EYHTLLRVSVKTEAGERSVAGTLFGDAAPRIVELF 441 Sphingomonas sp. Leaf339
WP_066710936 402 TERE------G---DYHTLLRVAVRTADGERSAVGTLFGDSAPRLVELF 441 Sphingomonas
WP_093665229 402 TERE------G---DYHTLLRVSVTTQDGERSVAGTLFSDQAPRLVELF 441 Sphingomonas gellani
WP_039093593 404 NERE------G---TYSTLVRVTVATSQGDRSVAGTLFGHGGPRLVEIF 443 Croceibacterium mercuriale
WP_047820047 404 NERD------G---AYNTLIRIKVDTEQGEKSVAGTLFGKSQPRLVDIF 443 Croceicoccus naphthovorans
EDL48232     414 HEKE------G---AYNTLLRVTVGTDSGDRSVAGTLFGADAPRLVEIF 453
5_pfamImport  80 SDKA------T---DFQTQIKLTVSDERGGRSVAGTLIAGNRPRLVSVE 119
WP_094407447 402 RDTA------S---DYHTLLSLTVETETGPLVLQGTLVGATLPRIVKLG 441 Elstera cyanobacteriorum
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