1VL4,6J6A


Conserved Protein Domain Family
PmbA_TldD_2nd
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pfam19290: PmbA_TldD_2nd (This model is not part of the current CDD release)
PmbA/TldA metallopeptidase central domain
This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation.
Links
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Statistics
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PSSM-Id: 523609
Aligned: 430 rows
Threshold Bit Score: 30.2752
Created: 20-Feb-2025
Updated: 25-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1VL4_A        122 RFEKLSVKEKMdmak---------kahESa-AKDE---------R-VV------MVPtvmyKDMvIKKIITNTLGLDVES 175 Thermotoga mar...
WP_013336485   98 GEKPRQLIGKYdgrvegeidrlidglnEAiqASLNegsqrnagvM----------------TFGvEERYYIDSTGLELED 161 Vulcanisaeta d...
WP_014126230   87 KGEALPTPREEreedfea---ladvalEAarAAegaer--nagaA----------------VLTyVSFQYEDTYGRRGRY 145 Thermoproteus ...
WP_012186599   96 HQGSVSTWDSYdssiedaeekvidmvkEAidASLSegsvrnagaF----------------TYGvSESMYSDHTGLNLNW 159 Caldivirga maq...
14_pfamImport   2 GLAPPAPVASSrwda---------ataQA--GPHDraal--vraFvDate--glETAgycrTAF-RSVAFANSAGQAVQG 65 
WP_015794614  108 RAPLPIPSADPdla-----------tgGA--GPEAraeq--vkaYvDEvtaaglTAAgfyrNRL-VVTAYANSEGQAVHG 171 Catenulispora ...
WP_014739183  102 GPAPLVSAGNPdea-----------taQA--TPAEraaa--vaaFvEaag--glSTAgyvqTSA-STAVLADTAGQHVRG 163 Modestobacter ...
WP_015625442  101 LTPPAGLHPDAgfde---------ataAA--GPQEraar--vrdFvDaae--glETAgfcrTNY-TSGGFANTAGHSAQG 164 Actinoplanes s...
WP_015620815  110 GLAAASSPDSSvwye---------eteAF--DAGArasl--aasAmrq----naGAAgmfgRAV-TQMAVVNSAGVARHT 171 Actinoplanes s...
WP_015102664  104 RPAAPVSDDHLlwhd---------dtaAF--DAPAriai--aaeAmTRarragcTAAgmvgRAV-TQLAVASSTGALRHV 169 Saccharothrix ...

1VL4_A        176 QMDGGFLFAMAIArdanprsGSWYELa-----RT---PEDlnpeeIGKRAAEEAISLI 225 Thermotoga maritima MSB8
WP_013336485  162 KASFVTLTIRAFIdd----lTATSVSis--ntLDgfrPRD-----AGAEAGRLVRLSK 208 Vulcanisaeta distributa
WP_014126230  146 SLNRAYLTIRSLRgd----lAATSAT-------AgrsLADlrpreVGEANSLLLRLAA 192 Thermoproteus tenax
WP_012186599  160 KGTFFNLAIRAFHnd----pELSSMDa-----LTgrrLSDidakgLGSRVGFMLSLAS 208 Caldivirga maquilingensis
14_pfamImport  66 HTAEAAMDGIARAg-----gVDGTARdca-erLAdldAAA-----LGRRAAAKARAAT 112
WP_015794614  172 TVVEAAIDGIAKTa-----tSDGASRqas-rrMSdlnGAA-----LGARAAAKALASQ 218 Catenulispora acidiphila
WP_014739183  164 AATSAACDGIARLg-----gADGVARsas-rrFAdldPAA-----LGARAAAKARAGV 210 Modestobacter italicus
WP_015625442  165 RTAEAAMDGIARLa-----gADGVARyas-grLAdvhGAP-----MGARAAAKARAGT 211 Actinoplanes sp. N902-109
WP_015620815  172 LATEASGSLTATVd-----eGTSHWIdlh-rsASalgVEQ-----AIERTVREATAGR 218 Actinoplanes sp. N902-109
WP_015102664  170 VATEATGSLTVGDg-----dGSAHWAnlhrsrDAlglDAG-----TVADTVARAVRSR 217 Saccharothrix espanaensis
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