Conserved Protein Domain Family
Exportin-T

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pfam19282: Exportin-T (This model is not part of the current CDD release)
Exportin-T
Exportin-T mediates the nuclear export of aminoacylated tRNAs. Its budding yeast homologue, known as Los1, is involved in nuclear export of pre-tRNA and in re-export of mature tRNAs. It binds to RanGTP and mature tRNAs cooperatively to form a nuclear export complex.
Statistics
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PSSM-Id: 523603
Aligned: 50 rows
Threshold Bit Score: 858.818
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCU80366      340 TEVRAQAEQLVQSFLPLLLRFFSDEYDEICSTVIPSLTELISFLRKS-H---P-LSSSYSSMLTPILNSVIQKMRYDETC 414 
XP_007875399  325 KEAYLRVDSLLFNTVPFLLRFLSDEYDETSSAVFPALTELLALFRKQkKi-gQ-IESSRKNLLESILNALIMKTKYDESL 402 
XP_018230084  325 KEIYIKADSLLFNTVPFILQFLSNEYDDTSSAVFPALNDLLALIRKQkKr-gQ-MDSSRNDLLKSILNALIIKTKYDKSS 402 
EXX75369      301 TATKAAAYGQIELLLPFLLKFLANEYDDVSCAVFSFVSALQAIFKKQkKqagS-LAGSQREFIDSLLKVIVIKMKYDDET 379 
XP_016608664  313 qniRESSFQLLQQIFPYLIQFLANEYDDTSSVLFPYLQAYTDVLKQYiKlggQgSAKPLEENLIALLRTVILKMKYDEEE 392 
ORY05766      327 PDARASSYTHIEKLLPYMLKFLGDEYDETSSAVFPFVSELLLMFKRQkKitnG-LTATQRELLASLIQVVVFKMKYDPDT 405 
CDH51865      319 DDAKVTAYGLIEQVLPFLLKFLADEYDDTSTAVFAFVNDILTILKKQkRtmqP-YTQSQQEFLGSLLSVVIMKMKYDDES 397 
XP_018292700  321 PEGKAATYALIEQILPYLLKFLADEYDDTSTALFAFVNDMLSIYKKQkKamqP-FTQSQQEFLRSLLSVVIMKMKYDEDT 399 
ORZ22296      320 SDAKATSWALIEQLSPYLLKFLANEYDETTTATFPFVNDLLSIFKKQkKamqP-FTQTQRELLGSLLSVFIRKMKYDEDT 398 
EPB90575      320 NEGKQAAWTMLEQATPYLLKFLANEYDDTSAGVFPFVNDMLYIYKRQkKqmqA-FSQGQHEFLASLLNVVIVKLRYDEDT 398 
CCU80366      415 SWG-NEDDQTDEAEFQELRKRLKNLQKGVAAVDESLYVEVLSNVVGNTFQRL-DQTDGLiDWRDLDLALHEMYLFGELTl 492 
XP_007875399  403 DWL-NDKKTDEYIEFLEMRKKLRTFQDMISSIDYNLYCNCILHLVTNGLEKA----FSEaNWRHLELILYEVFSFGEGLk 477 
XP_018230084  403 DWL-NEAQADENAKFLEIRKKLRTFQDMVGSIDYDLYCNCILNLVTNGLNKG----FSEvSWRHLELILYEILSFGENLk 477 
EXX75369      380 DWGgTEEDEVEEAEFLEMRKNLKTFFDAIYNIDEQLFTSYVHTAVINTLDKYq-RVGNSiDWRELELALHVLLLYGEAF- 457 
XP_016608664  393 EHEfGQQAGELDALFMELRQNLKKHFNAIATIDEALFVNYILSVVTDTFGKIaSSPGSv-SWSEAELSLHLIYLLGESV- 470 
ORY05766      406 EWn-DEEEDDEEILFSELRKNLKLFFDSIAAIDQELFSSYVQSCIVSTFETV--QNGATtHWTDVELSLHLAYLYGEAI- 481 
CDH51865      398 DWGnDEDEPEEEALFMELRKNLRIFADHIAAINEELYINYVHSVVMDTLNKY--KAGNElDWRTVELCLYVLFTYGEAL- 474 
XP_018292700  400 EWGnEEDEPEEEALFAELRKNLRIFADHIAAISNELYIGYVHSVVMETLSKY--KSGAElDWREVELCLYVLYTYGEAL- 476 
ORZ22296      399 EWGaDEDEPEEEALFAELRKNLRVFTDHAASIDDELYVSFVHSTIMETINKF--KSGADlDWREVELCLYVLYTYGEVL- 475 
EPB90575      399 EWSdDQDEPEEEALFFEMRKNLRIFAEHIAMINEELYVGYIHSFVMETINKY--KAGTElNWRDVELCLYVLYCYGEAL- 475 
CCU80366      493 VNGSIYFKGQPSGP--AADRLIAMMTKMVNSgkhwascdymirslstqGITSFNHPAIQLQYMEICVRYCSFFEYHTMYI 570 
XP_007875399  478 -VLA-YIDNN-DND--SPTVLGQLLGIIINS-----------------EVSSYPHPSIQLHYLEITVRYASFFEYQPSLI 535 
XP_018230084  478 -VTT-YVNNN-NNN--SFTILGQLLGMIINS-----------------EISSYPHPSIQLHYLEIAVRYVSFFEFQPSLI 535 
EXX75369      458 KGQLIFVLKH-NNEiiAFTPLGEMVSKMIQC-----------------NISTYPHPSMPLIFFENVARYYQFFEVQPDCI 519 
XP_016608664  471 -KVQ-FAVGEPPAA--VVTPLGQMLTKMITS-----------------NVSAYPHVSIPLIFFENVTRYSQFFDLFPQYI 529 
ORY05766      482 RGPMTFVTTQ-GNTs-VLTPLGEIVAKMVKS-----------------NVSAYPHPSIPLPFFENIVRYAQFFETRSDLL 542 
CDH51865      475 PKGAMHFVNP-NDPs-VLTPLGEMLVGVVTS-----------------NISAYPHPSAALQFFEDIARYYQFFDYRPEHL 535 
XP_018292700  477 PKAAMQFVNG-NDSa-SLTPLGELVSEMVMS-----------------NISAYPHPSAPLQFFENITRYYQFFEHRADHL 537 
ORZ22296      476 PKAAMVFVNA-NDPn-VLTPLGELVQEMVTS-----------------NISSYSHPSVPLQYFENLVRYYQFFELRPDYL 536 
EPB90575      476 SKAAMIFVTP-NDA---LSPLGELVSEMINS-----------------NISAYPHPSCAMQYFENVTRYYQFFEHRPDHL 534 
CCU80366      571 PYVLEHFV--RFVHHKHVRVRTRSWYLFQRFVKHLRIHIGSIAETVIESVRDLLTISAEIKNE-H-TDGDVSSDENDQIE 646 
XP_007875399  536 PKVLETMLdhRGLRHHNTHIKKRAPYLFLKYLRLLSNRIENFSETTLEAIRDLLTIKLEPIPEtN-INNGINT-DITPIK 613 
XP_018230084  536 PKVLEAMVdqRGLYHHNTHVKKRACYLFSRYIRLLSNKIGNYAETTLKAIQDLLVVKIKHISNtN-TDNNVNT-DITTVK 613 
EXX75369      520 PTVLGAFVdlRGLHNAILQIRTRSWYLFHRFVKLLKSRMGPYVETVLTNIQDLLVVQANLSSI-DvSDGTITK-----DQ 593 
XP_016608664  530 PNVMEAFVdqRGMHHDAPFVRSRTYYLFRQYVQSLKSKLSPLVNNVLASIEDLMVVQLPEPQK-----P-VRDGEEEVTA 603 
ORY05766      543 PEVLGPFLdnRGLHNSRKVTRSRSWYLFYRFVKLLKAHMGPYVDGMLNSLMDLLVIQVDVSDS-VsGASN---------S 612 
CDH51865      536 PQALAAFVdaQGLHHPSKPIRSRCWYLFHRFVKNLKSRMSQYVDTILNSMGDLLTVQAEPPVQ-AnTADGTPM-----PA 609 
XP_018292700  538 PQALAAFVdtRGLHHPLNQIRSRCWYLFQRFVKMLKPKMGPYVETLLSSIGDLLTIQAETPVE-SnTMDGMPI-----PA 611 
ORZ22296      537 PQALESFVdaRGIHHSLKQVRCRCWYLFHRFVKSLKPKMGPYVETVLSSLGNLLSIQAELPVL-TnNADGMPL-----PA 610 
EPB90575      535 PQALAAFVdtRGLHHPVKQIRTRCWYLFQRFVKNLKPKMTPYVENVLSSLGDLLSIQAEPVVE-TnTMDGMPI-----PA 608 
CCU80366      647 D--ATFTAQLYLYEAVGCICSIPAIPIEKQAFYAHTIFDPLFSEIEKNLAQAKS-----GNLQAVQQIHHVIMALGTFSH 719 
XP_007875399  614 G---LFESTFYLFEAAGLLISTNTISKEKKISLTYSILEPLFSDFQKYLSSDRD------NDINVLYIYHIIMAIGNFSK 684 
XP_018230084  614 D---LIDSTLYLFEAAGLLISLDTIDKTKKICLTESILKPLFSDLQICLSQDIN------DNNNILHIRNIIMAVGNFAK 684 
EXX75369      594 AmeGGFDDQIYLFETVGILITVDTIPTERQTEFAKIVINPLLADIERNLSKVMSe---pEDLLHVLQLHHLIIAIGSIGK 670 
XP_016608664  604 T---SFDSQLYLYEAVGILISLDGMTTEKQAQLLTVVLTPLMRQIEEIMRNELYrrdtpDNIVFTLQLDHLIRAIGNISK 680 
ORY05766      613 G--SSFDSQLYLFETVWV-------------EYLQFVFNPIVTTIQECTNKARQa---pDDPLIPIHLHHLVMAIGSISK 674 
CDH51865      610 A--SLFDSQLYLFETVGMLISLEGMDVMKQTEYLKIVLGPLVDGIQKYMERGYNp----DDELYLLQLHHYVMAIGSVAK 683 
XP_018292700  612 A--STFDSQLYLFETVGTLISLDSVDVMKQMEYLQIVLEPLVEGIRNSMSQGYNp----EDELFMLQLHHYIMAIGSVAK 685 
ORZ22296      611 A--SIFDSQLYLFETVGMLISFEQLESSKQTEYLQIALQPLVDGIQSTMGQGYNg----EDELYMIQLHHYIMAIGSVAK 684 
EPB90575      609 A--STFDSQLYLFETVGLLISLEGIDPMKQTEYLKIVLEPLVEGIQKAMAQAVS-----DDELFLLQLHHYIMAIGSVAK 681 
CCU80366      720 GFSEFLPKnTVIanHVPDRSVSEQFGRAAEAILIALEALKSSFEVRTAARASLSRLMGVLGADMLPFLPRWIDGLLYANS 799 
XP_007875399  685 GFPDISREf--P--A--IDSISKTFLQASEVILVALETLKHKEIIREAARFSFARLTNILDLEVLPKFPRLINGLLSE-S 757 
XP_018230084  685 GFPDISRKs--S--I--INPISETFLQASEFILIALETLKHEEIIREAARLSFVRLTNILDLEILSKFPRLINGLLSE-S 757 
EXX75369      671 GFPDALKTe--V----PTAEWVVLLKQSVEVILVAFKALSRFEIVRESARFAFARFVNVLGVEILPYLPELITGLLNE-S 743 
XP_016608664  681 GFPDVDQA-SKV--VQTVPAWALVFQQALGAIVAVLERLHESELIRNAARFAFQRMVGCMGHDILNHIGPLITAGLLSNS 757 
ORY05766      675 GFPEAKEGv--S-------PIAQVFKQATECILVLLENMNKYEVVRESARFAFARLLNCLGSEILPYLLPLINNMIAE-C 744 
CDH51865      684 GFPNAPKEs--E----CTQPWAAVFKQATEIILNVLQAYNRFEQIRDAARFSFARLVNCLGSAVLPYLPTLINGLLVE-C 756 
XP_018292700  686 GFPDVPKAs--A----ATAPWVVVFNQATEIILNVLQTFNQFLLIRDAARFSFARFITCLGSEVLPYLPTLINGLLTE-C 758 
ORZ22296      685 GFPTLPKGa--T----CNQAWAGVFVQATEIIMNVLQTYNQVELIRDAARFSFARFITCLGSEILPYLPTLITGLLTE-C 757 
EPB90575      682 GFPTLANPa--E--S-AQQPWTVVFIQATEIILSALQSYNQMAVIRDAVRYTFARLITCLGTQVLPYLPSLINGLLTE-C 755 
CCU80366      800 SKEEIALFLRSLDQVVFGFKKKVYVVLDSLLTPLLHHVFASLAEPITGTDDEIQLSELRREYLTFIQIILNNDLSNVLIS 879 
XP_007875399  758 KTPELIDFLPFIGLLVHKFKSNIYDILNSLFMPLLNRIFQSLNESTEGTDDIIIHNDLRKKYLEFVLALMNNDLDTVCVS 837 
XP_018230084  758 KTSEIIDFLPFLGLLAHRFKSNIYDILNTLFTPLLNRIFQSLNQPAEGTDDIINQNDLKKKYLEFVLGLLNNDLDSVFIS 837 
EXX75369      744 QVSELVDFLPFIGLLSHKFNPSIYDILNELICPLVTKIFYVLNQTPSGTDEAMLLLNLRKAYLGFILSLLNVGMDAVFIS 823 
XP_016608664  758 TRQELVDFVPFIGHITHKFKPAVFPIMNELIGPLMDRIFSSLNQPVDGTDDAFSLLELRKAYLNLLATIFNADMEGTLVT 837 
ORY05766      745 QVTELVDFLPFMGLVIHKFKPSIMSALNDLLLPLLNKVFTFLNQTATGTDEAVLLLDLRKSYLNFIISILNSEMDDVFLT 824 
CDH51865      757 QLTELVDFLPFIGLITFKFKPMIQSIMDELLLPLVKRVFDFLNVAPSGTDEAVLLIDLRKAYLNFITGLFNADVSAVLFS 836 
XP_018292700  759 EITELNDFLPFIGLVAHKFKPMIHNIMDELLLPLVKRVFDFLNTSPSGTDEAMLLFELRKAYINFIISLFNAELESVLVS 838 
ORZ22296      758 QITELVDFLPFIGLIAHKYKPMIRNVMDELLLPLVKRVFDFLNTTPSGTDEAILLLELRKAYLNFIVSVFNAELDGVLVS 837 
EPB90575      756 QVTELVDFLPFIGLIAHKYKPMIEPIIDELLLPLVRRVFDFLNTTPSGTDEAFLLLDLRKSYLNFVLSLFNANLEKVFVS 835 
CCU80366      880 DLNLAYFESLILSVTSLAAIsssnGtGNIAPIRMAFVNMTLMTQLWGGLDHANt------Ng---qPATKs------sSP 944 
XP_007875399  838 DINQPNFETFLRSIIHFAAD----I-SDPSTEKIAFSILNKMVNAWASDQS-Hi------S-----DIKT---------- 890 
XP_018230084  838 DVNQPNFEAFLQSIIHFAAN----I-SDPSIEKIAFSILNKMITLWASDQS-Qi------S-----DIKI---------- 890 
EXX75369      824 DLNQPRLESILQSVVHYASDp-----ADVPSARTAFNILSKTLVLWGGPIQ---------Ss----TNNTs------tNS 879 
XP_016608664  838 EANMPRLTTVVQSVLHFVKEs-----GDRTSQKLAFSVLTKMVLSWGASEDSQingidpkTykkgiPGAKsdkakhttPP 912 
ORY05766      825 EKNAPHLNTLLQSILYYALDs-----EDISTQKVAIGILHKFVNIWGGSNAn-------------------------gAN 874 
CDH51865      837 ERNIGYFDTILQTILHFAKDn-----NDPATQKMAFGVFLKMVTAWGASGA----------------------------- 882 
XP_018292700  839 ERNLSHLNTILHTILHFAKDn-----SDPTIQKMAFGVFLRMVNAWATSPQ----------------------------Q 885 
ORZ22296      838 ERNIGHLNTILQTILHFSKDn-----TDPTTQKMAFGVFLKFVTAFSSTAQ----------------------------Q 884 
EPB90575      836 ERNIESLETILQTFLHFAKDn-----SDPTTQKMSFGVFLKTVNSWASNTA---------------------------AP 883 
CCU80366      945 QfAFPGFERVLVERFHPICWDVMRNSTFKPdTDANSKQILHEIAGLEHAIYKKTGHLFLQHLQQeFFPSIGVDGS---EF 1021
XP_007875399  891 RkIVPGFDQFIFHSLSSLCFEVPSKQSFNP-RDTQAIIVLSEISNLQFTIFKKKEIEFERYLYNiYFPSVNIPQEiakEY 969 
XP_018230084  891 KkTVSGFDQFIFQSLSSLCFEVPSKQSFNP-QDTQTITVLSEISNLQFTIFQKKQAEFERYLCNiYFPSVNIPKEianEY 969 
EXX75369      880 GrPLPGFEQFMYDHILRICFEVPMKPEFCI-TDGQSNLILNEISSILKTMYSLRGHELLDYLRRvWLP-----LDsadEF 953 
XP_016608664  913 KpPLPGFEQFIYENIVPILFEVPMNASFNP-SDGQCYLVMSEISSLQKTLVSAQGAKYLEYLVNvYLPSIGCPPNaaqEF 991 
ORY05766      875 TkSIPGFEQFIYEHIVRVCFEVPTKRSFDF-ADGQAVLVFGELSSLQKSILLKQGPDFLNFMRGvYLPSVNCPPPmieEY 953 
CDH51865      883 ---TPGFNQFVYNEIVPATFTVPMQATFNL-SDGQSTLVFGELTSIQKMLYEKQGNEFLEYISNvFLPSIQCPPEtasNY 958 
XP_018292700  886 QgSIAGFDQFVYNELIPTTFAVPMHVAFNV-ADGQSLLVFGEITGIQKAMYTKQSNEFTEYMTNvFFPSIQCPREgaeRY 964 
ORZ22296      885 PtVAPGFDQFVYNELIPMTFSVPMNNSFNV-ADGQSMLVFGEITGIQKMLYTKQGNDYVEYMLNvFFPSIQCPREtaeRY 963 
EPB90575      884 GpTVAGFDRFVYNELLPITFSVPMSAAFNL-ADGQSILVFGEMTSIQKAMCVKQGADFIEYMKGvFLPSIQCPPDtaeRY 962 
CCU80366     1022 IQVLSngsDRKDLVKFLQGLVKqiR 1046
XP_007875399  970 VEALKq-lNAKQFKTFFQNFINklK 993 
XP_018230084  970 IEALKh-lNAKQFKFFFQNFINnlR 993 
EXX75369      954 LQALQq-lELKEFRKYFQTYVQrsK 977 
XP_016608664  992 VAALQr-tDVKELRIFLQEFFMrmK 1015
ORY05766      954 CQAIQq-lELKQFKKYFQNFIRnsT 977 
CDH51865      959 CQALQq-cDARAFKKYFQTFIQeaK 982 
XP_018292700  965 CQAIQq-yDNKEFKKYFQTFISeaK 988 
ORZ22296      964 CQAIQq-yDAKQFKKYYQSFISeaK 987 
EPB90575      963 CQAVQq-yEGRQFKKYFQSFISeaK 986 
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