3A6P


Conserved Protein Domain Family
Exportin-5

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pfam19273: Exportin-5 (This model is not part of the current CDD release)
Exportin-5 family
Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 yeast homologue, also known as Msn5, is involved in nuclear import of replication protein A and export of Far1 and transcription factors Swi5, Swi6, Msn2, and Pho4. Its Arabidopsis homologue, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs).
Statistics
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PSSM-Id: 523599
Aligned: 9 rows
Threshold Bit Score: 837.869
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3A6P_A        313 EKHYVFLKRLCQVLCALGNQLC------ALLGADSDVetpsnFGKYLESFLAFTTHPSQFLRSSTQMTWGALFRHEILsr 386  human
Q54PQ8        308 EDDYSFHKRITQALTILGTVHL------NAYDDKHKIpn--nYNIYLQLMLQMVSHPSILLSSFVLPFWHTFIKVESLel 379  Dictyostelium...
KMZ72157      314 ENEMEFMDVFCESMVSLATSNM------QCILRESTT-----LSLYIQQMLGYFQHFKFAIHFHSLPFWLLLLKGISPrg 382 
XP_024534315  303 SAPLEFAECLCEALVALGSQNL------QVISSNNQK-----LATYYRQMLKFLQHSEFSLHVQALPLWLGLLRDSLSve 371 
XP_024381270  319 EDVDQFGECLCEAMVAFGLQNL------HCVARNSPK-----VTDYLNQMLCFLQHPKLALHSLALPLWTTLLRESSLam 387 
O14116        330 TPEYILLKKLSETIVALGQYNYldsnrrKCIKLTS-------LDTYSLLVLEIMKHPSLLISAISQHFWVLALRDPIIsk 402  Schizosacchar...
P52918        332 ETKYPIIKKFVDMISCLY----------VCVPKIKETng--qIQKYFKLVLKTTYNPSLIVSGLTLDLWCTCLRNDEYlp 399  Saccharomyces...
Q9HAV4        313 EKHYVFLKRLCQVLCALGNQLC------ALLGADSDVetpsnFGKYLESFLAFTTHPSQFLRSSTQMTWGALFRHEILsr 386  human
XP_002272927  313 ESEFEFAEYICESMVSLGSSNL------QCITGDSTI-----LSHYLQQMLGYFQHVKLTLHYQSLPFWLALMRDLVSkp 381 
3A6P_A        387 dp-------------------------------lllaIIPKYLRASMTNLVKMGFPSKTDSPSC---EYSRFDFDSDEDF 432  human
Q54PQ8        380 sy--------------------------------leeVIKQIMETMLVKFVRIGDPEKSDSEQS---KYSEIDFGTSKEW 424  Dictyostelium...
KMZ72157      383 hnsvqssidnstasisgsasvqadndkkalillinddICAAILDLSFQRFPKRI-TSTGEPFAAgslELWSDDFDGMVEF 461 
XP_024534315  372 rnkviia---------------------rptvvvpieTASVLLDVAFQKLLKDGQ---------------EEEFTSAVDY 415 
XP_024381270  388 sttdqqglteke------------kekrshavhispdFCAVLLDVAFQRLLIKDGGDTSAEDESg-----iQEFSSANDF 450 
O14116        403 he-------------------------------kfqiVYPELLSIASERLLRFEDAVVELIPESataKYLQEDVEGVSAV 451  Schizosacchar...
P52918        400 kl--------------------------------ekyVIPDLLQFAADALVYYEQIDGHISk-----KFAEIDFQSKSEF 442  Saccharomyces...
Q9HAV4        387 dp-------------------------------lllaIIPKYLRASMTNLVKMGFPSKTDSPSC---EYSRFDFDSDEDF 432  human
XP_002272927  382 kivapaagdgsvdnnpgsgsgqvdnekrklqsfvnddICGTMLDVCFQRLLKREKVLPGTSFSLgplELWSDDFEGKGEF 461 
3A6P_A        433 NAFfnssRAQQGEVMRLACRLDPKtsfqMA----GEWLKYQLSTFLDAGSVNSCSavgtgegslcsvfSPSFVQWEAMTL 508  human
Q54PQ8        425 SNFfggvRTRYLDIIKLITIQRRE----MAyifiATKVADVLDALKANLNVASLS-------------HEQTLVLESHSH 487  Dictyostelium...
KMZ72157      462 GLY----RSKLLEIIKLVVFHKPL----LA----VTNISNRINSSINGGPNTS-P-------------INAMSLLECWQP 515 
XP_024534315  416 SQY----RGRLIELIRLVAHHHHD----LG----ITKVVQRLDVFLTK---EKIS-------------SQEYFILESTHT 467 
XP_024381270  451 RQF----RSRLVELVRHVAAQQPR----LA----TSKAAERLQMTISSSNYESVS-------------SKEITALETTQT 505 
O14116        452 HSFcgnfRRFMFDIVRLTVSITPI----ES----LNWIQNRFQSTVLGNMEDIQSqtef-----fsktSPLYLTMDVGFS 518  Schizosacchar...
P52918        443 QTFcstyRKRIRDIIRLISCVELD----LT----YDWLNNRLNNYFSSPFGQQVLsstf-----ldhkLEPYLGALSQYM 509  Saccharomyces...
Q9HAV4        433 NAFfnssRAQQGEVMRLACRLDPK----TSfqmaGEWLKYQLSTFLDAGSVNSCSavgtgegslcsvfSPSFVQWEAMTL 508  human
XP_002272927  462 SQY----RSRLLELARFVASDKPL----IA----AIKVSERIATIIKSLLLSPMS-------------AQDIAVMESMPM 516 
3A6P_A        509 FLESVITQMFRTLnREEIPVNDGIE-----------LLQMVLNFDTKDPLILSCVLTNVSALFPFV-TYRPEFLPQVFSK 576  human
Q54PQ8        488 ILDSILLNIKDFTpESSLFFNKEQQqqpniiqltdrVLNLLFEINSTEPNITSFQIDCLQAYILYY-QTNPESIKFLLNK 566  Dictyostelium...
KMZ72157      516 GLETIINSTFD---ETKVCINSEIKleihr--ilegLLQQFMHSKTNDPAHAIILGRYLNTFGPFL-KCFPDSVGGVVNK 589 
XP_024534315  468 MLDAVVTGCFARGgtse---------------llggLLQRLLTVHWSEPELVEIHAKCFDALVPYI-KNVPTAVPTVIQK 531 
XP_024381270  506 YLENILNGIQEKTlAAALATTASSNelrt---iledILQLLLSVKWNGPALVELHTRHFDAMSPYF-KHASAAIPLVVGK 581 
O14116        519 TIEAFLHGVTRWNeN----TSDDPAtyeiilqnlflWCKQLVEINFKDPMLITRLISVLVLFTSILaRENTTLLGVVLEK 594  Schizosacchar...
P52918        510 IVECFINGCIRWKiWYPTGDDYDEKldsil-qkleiLSNQLIALNLREPLLLKKQIQNFALFLTML---KDNVLFTLLEK 585  Saccharomyces...
Q9HAV4        509 FLESVITQMFRTLnREEIPVNDGIE-----------LLQMVLNFDTKDPLILSCVLTNVSALFPFV-TYRPEFLPQVFSK 576  human
XP_002272927  517 ALENIASVVFDGS-NEYLGGSSETQlalcr--ifegLLQQLLSLKWTEPALVEVLGHYLDALGLFL-KYFPEGVGSVINK 592 
3A6P_A        577 LFSSVT----FETVEESKAPRtRAVRNVRRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQ-LlSNELLLTQMEKCALMEA 651  human
Q54PQ8        567 IVPLIP----FPGLDNPNRSFqNSVLHTRRRAISSLIGISTNISHLMKPYFDILYKSVVE-L-FQKNVVTETEKVMLFHL 640  Dictyostelium...
KMZ72157      590 LFELLT----SLPLVLSDPST-NNVRLARLQICTSFIRIAKAADKSLLPHMKGIADTMAY-L-ETEGRLLRSEHNLLAEA 662 
XP_024534315  532 LFQLLV----TVPVVSKEASStNS--KARFQVCTSFLRIAKLAGPALFPHMQIVAETMTR-L-QQERHLLRGEYILLGES 603 
XP_024381270  582 FFDLLT----SLPVYREYGDTvKDTMRARLQVCTSFLRLARAGDAAMLPYMQGIAETMTT-L-HREGRMVRSELNLLGES 655 
O14116        595 IISAVTydntSASYGFSDV---QKINEMRSRCCFELVRLGELMPNPLMNIFDQLQSIIDQ-L-DNATTLTGSEIVMLKTF 669  Schizosacchar...
P52918        586 IITSATmdypEINLEERGAES-DAVRDLRYACGIELNRMALLMPESLKKIYPDLESVIARiM-PN---LSYHEKISFKSF 660  Saccharomyces...
Q9HAV4        577 LFSSVT----FETVEESKAPRtRAVRNVRRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQlL-SNELLLTQMEKCALMEA 651  human
XP_002272927  593 LFELLT----SLPFVVKDPKT-SSARYARLQICTSFVRLAKSAEKSLLPHMKGIADTMDY-L-QREGCLLRAEHNILGEA 665 
3A6P_A        652 LVLISN-QfKNYERQKVFLEELMAPVASIWlsqdmhrvlSDVDAFIAyvgtdqkscdpgLEDPCGLNR------------ 718  human
Q54PQ8        641 LIVFSN-NlPSYQQTLDFYKGILTPIIEQW---------VSLEMSTA------------LSSPDAFIQylglsiads--- 695  Dictyostelium...
KMZ72157      663 FLVMSS-S-SGQLQKQEILAWLLEPLNKQW---------TQLEWQISf-----------LSDPLGLTRl----------- 709 
XP_024534315  604 LLVAGS-T-AGQEQQNQVLEWLLGPFRDYW---------CHSDWQQKy-----------LCDPAGFVRl----------- 650 
XP_024381270  656 LLIVGS-A-AGGEQQLQVLGWLFGPMQQQW---------IQPAWQDQy-----------LANPASLVRl----------- 702 
O14116        670 LFVITQfSdVNIEVKNEYFEKLVGPVVKTW---------LDVQPP--------------VNSPMEFLNhigfpqmaeyls 726  Schizosacchar...
P52918        661 LLIIVL-K-SSLDMKEERFAAIVDPELLAWsdkttvvglSDLHW---------------FMERLGIVQiaeyfqrrdide 723  Saccharomyces...
Q9HAV4        652 LVLISN-QfKNYERQKVFLEELMAPVASIWlsqdmhrvlSDVDAFIAyvgtdqkscdpgLEDPCGLNR------------ 718  human
XP_002272927  666 FLVMAS-V-AGVQQQQEVLAWLLEPLSKQW---------IQVEWQQTy-----------LSDPTGLIRl----------- 712 
3A6P_A        719 --------------------------ARMSFc-------VYSILGVVkrTCWPTDLEEAkaggfvvgytssgNPI----- 760  human
Q54PQ8        696 ------------------qnldatlvSRRKN--------IQYVASTL--QIFWKKSQIP-------------TNSsdelf 734  Dictyostelium...
KMZ72157      710 -------------------------cSDAQF--------MWSIFHTV--AFFERALKRSgirkg---hgslqACTsavd- 750 
XP_024534315  651 -------------------------lGTTTTenlsgdegMWYIFHSI--HFFEKALRRC---------------Aagve- 687 
XP_024381270  703 -------------------------fTENSSndda-haeMWSIYHTV--NFFERALRRCanps-----gktySGSsatvh 749 
O14116        727 akypynadytqfeldadaasyqsnleTGRKW--------LWPIKCLG--RFCEATCSNK--------------------- 775  Schizosacchar...
P52918        724 nsdll-----sipiddegkelkseltKRWQS--------LFPVRATR--MFIHYSMQSIktdeefkmlqdlwRPR----- 783  Saccharomyces...
Q9HAV4        719 --------------------------ARMSFc-------VYSILGVVkrTCWPTDLEEAkaggfvvgytssgNPI----- 760  human
XP_002272927  713 -------------------------cSETSF--------MWSIFHTV--TFFERALKRSgirkg---slnsqNSStas-- 752 
3A6P_A        761 -----------FRNPCTEQ---------ILKLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGlpq-- 818  human
Q54PQ8        735 apfisngisynGKWPISSF---------VKQVLPGVLSLTRTLHQLWMPEHRAKIHPSLSTIFNLDDSITAPLLG----- 800  Dictyostelium...
KMZ72157      751 --------gsvSQNPMLSH---------LSWILPPLIKLLRCIHSLWSHQVANSLPLEMRAAMSISYTEKAGLLGevvsk 813 
XP_024534315  688 --------gnpSSHPMAVH---------MSWILPPLIQLLRCLHSLWIPSILSTLPPPVRQAIHLSASEQASILGe---- 746 
XP_024381270  750 nvdmdgavtpaSSHAMIQH---------LTWMVSPLLKLLRCIHALWSPSVASSLPPQVQGALTMAEAEQASLLGelatt 820 
O14116        776 -----------HIHPSEFEgqknlwqviLPNVVPNLLKLVEQLHCCYEPSFISGLGMHNSSILQKSIVERFWLHGvsqis 844  Schizosacchar...
P52918        784 ----------------------------IVPILPYITRLLYQLQSYHDPDNWKGLPTVVQSFVKYSTIERFWEAGasnks 835  Saccharomyces...
Q9HAV4        761 -----------FRNPCTEQ---------ILKLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGlpq-- 818  human
XP_002272927  753 ---------ftPLHPMSSH---------LSWMLPPLLKLLRAIHSLWSPPVSQSLPGEIKAAMIMSEVERTSLLGevnpk 814 
3A6P_A        819 -----------------plLELN--DsPVfKTVLERMQRFFSTLYENCFHILGKAGPsMQQDFYTVEDLATQLLSs-AF- 877  human
Q54PQ8        801 -------------------FEYHk-EqKSeSSNVTFLRNILDCLRDACYEIVGYGFN-HSDELFSLPDLPLVLLDs-VF- 857  Dictyostelium...
KMZ72157      814 qtkg------llassdghqMEGNa-DgHA-ESGENSLRNWLKAIRDSGYNILGMSAS-IGEYFFQCLDSSSVTLA--LM- 881 
XP_024534315  747 --------------------------sKTvDHKEDELRNWLKSVRDSGYNVLRYASSrLGNQFFVNMSGLSGPLAtgLM- 799 
XP_024381270  821 rgpagassmtdkgvdagssIEHNk---------VKEIRTWIKGIRDAGYNILGLAAIrLGEGFFVDTDGRPAAMAtaLL- 890 
O14116        845 ---------------knqfLEESykMdVSaNKLIHSFGHFLRRLREYCYYAIA-SFMrLGQAFFCVPGLSKQFLTa-FF- 906  Schizosacchar...
P52918        836 ---------------kdefIDEHmkAmQTlRDFADSVGHIIRYTREYTLLVLSAISS-LGSVFYLLDESPDLLLNsiAIf 899  Saccharomyces...
Q9HAV4        819 -----------------plLELN--DsPVfKTVLERMQRFFSTLYENCFHILGKAGPsMQQDFYTVEDLATQLLSs-AF- 877  human
XP_002272927  815 lsks------vagfidgsqIDTNk-E-YA-ESHETDIRNWLKGIRDSGYNVLGLSTT-IGDSFFKCLDISSLAIA--LM- 881 
3A6P_A        878 -----VNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEaad---- 948  human
Q54PQ8        858 -----SYLESIENRHLKLLVKHILNYLIKNCPTKLEHTIFEPILPLLFSVLFNRIKAGWELIKLRSQKGEKEN------- 925  Dictyostelium...
KMZ72157      882 -----ENVQSMEFRHIQKLVHLAIIPIVRYCPPDLRKLWLHNLLLPLFLHCQQALSCSWSGILHEGRAKVPDRfgdl--- 953 
XP_024534315  800 -----ESLSSMEFRHLRSLVHSVIQSFVRFCPHSLREVWLGQLLPPLLVHCHATLPLAWENLVREGAVKTGTLfavd--- 871 
XP_024381270  891 -----ENIEHMELHHIRQLLHLVVIPVVKVCPANLWDPWLRLLLPPILIHCHRVLSISWTSLIKEGALNIPSNwslntdv 965 
O14116        907 -----SHAAGLSLHQWTSMVNVVIKPYCVNCPAELRDECLLPLLPALLSELDHKLVSEWRRINDRGLLVEEDAeetg--- 978  Schizosacchar...
P52918        900 kpgsnEISPGVSTHGWKHIMNIAIRPILKGCPKDCLGKFMPAFLPKLFEILDLLLCQKWS-----SHMNDMDMnpvpt-- 972  Saccharomyces...
Q9HAV4        878 -----VNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSllcgede------- 945  human
XP_002272927  882 -----ENIQSMEFRHIRQLIHSVLIPLVKFCPSDLWEEWLEKLLHPLFIHSQQALSCSWSCLLREGRARVPDVhail--- 953 
3A6P_A        949 -----enpESQEMLEEQLVRMLTREVMDLITVcC-----VSKKGAdhssappadgddeemmatevtpsamaeltdlgkCL 1018 human
Q54PQ8        926 --------EKNEIVEDKILRDVSMEFLMCCSN-I-----ITQSPN---------------------------------YI 958  Dictyostelium...
KMZ72157      954 ----sgldLKVEVMEEKLLRALTREICQLLSF-V-----ASPSLNngippieqfgntqsvaisslkdldtftsnslvcFL 1023
XP_024534315  872 ----gssgINTELVEERMLRELTREVCTLLAI-M-----ASSELNpeqqp------------------------gmlcYV 917 
XP_024381270  966 snqssmqqIQSEVMKEKLLRDLTRETCQLLST-A-----ASPTHNratqqdasegdggsme--vvgtqqlnkmnnlvwFL 1037
O14116        979 ----edddLSEEMIEESLLRHLTYATAKLITE-Tfl--qITPTQSrsnvsssligk-----------etvegpvklseYV 1040 Schizosacchar...
P52918        973 ----dddqMTEEILEENLLRQLTTVVVRIVID-CvgqgnANPNSAksrlnnh--------------------qmemrkII 1027 Saccharomyces...
Q9HAV4        946 --aadenpESQEMLEEQLVRMLTREVMDLITV-Cc----VSKKGAdhssappadgddeemmatevtpsamaeltdlgkCL 1018 human
XP_002272927  954 ----agsdLKVEVMEEKLLRDLTREICALLSV-L-----ASPGLNtglpsleqsghvsrgdmsslkdldafastsmvgFL 1023
3A6P_A       1019 MKHEDVCTALLITAFNSLAWKDTLSCQRTTSqLCWPL-----L-KQVLSGTLLADAVTW-LFTSVLKGLQMHgQHDGCMA 1091 human
Q54PQ8        959 FSSIDVMTPMVYGISSCLMAMDTPILKKSLI-VSTQLl---vD-HEKVNDPKFFKLIGSeMFGCCIKILIVN-KFAEFSN 1032 Dictyostelium...
KMZ72157     1024 LVNKDLALPVLQIIIKAFSWTDGEAVSKVAS-FCSTMi---lL-TISTKNIELNQFVVKdLFSAIIGSLTLE-SNALYGS 1097
XP_024534315  918 IQHSAAAFATVHLGIQSLQWPDSDAVHRGAV-FCGAVi---dV-AGPLNDTNLREIVGKdMFTAIIQSLTLE-SNSAAHA 991 
XP_024381270 1038 LQLREAATAALHVGIDALEWPDSESVHKAFV-FCAAVt---nV-ATLSGDSQLQEVVAKdMFSSAIRALMLE-SNASAQS 1111
O14116       1041 LDNAIICEPLLCTLCHLLVIHDSRTVGLVVNaFLAITp---lL-VSEQAHSLVREFICQqVFQSVILAIHDP-YFESMQS 1115 Schizosacchar...
P52918       1028 FNDLNTLAPFLKLLNHLISFKDTKCS------FNSILvmkccLtSVLNQNNTVDEYFTFeVMKNLLLNVLCNsAFKDSFH 1101 Saccharomyces...
Q9HAV4       1019 MKHEDVCTALLITAFNSLAWKDTLSCQRTTSqLCWPL-----L-KQVLSGTLLADAVTW-LFTSVLKGLQMHgQHDGCMA 1091 human
XP_002272927 1024 LKHKGLALPLSQISLEAFTWTDGEAVTKVSS-FCGVVv---lL-AISSSNVELREFVAKdLFYAIIQGLALE-SNAFVSA 1097
3A6P_A       1092 SLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDS--LDQFDCKLLNPSlqkvADKRRKDQFKRLI-------------AG 1156 human
Q54PQ8       1033 DIQSIIRLIYMKYYQICNYPQEILLSLPNITPPI--LQAFNKDLISTR----SEKSQKVLFKKLL-------------QD 1093 Dictyostelium...
KMZ72157     1098 DLVELCRLVFVYLSDRDPTPKQILLSVPGIKMED--IVALKESLEKIN----SPKEQKLQMKSLL-------------LL 1158
XP_024534315  992 ELLGLLREILVKLSPHTSTPKQVLMSLPSISQQE--FANFETAFNKTT----SVKEQRQHIKNLL-------------LA 1052
XP_024381270 1112 ELVGLLRDIYLQIGSRLSTPRQVLLALPSISPDS--LSTFETALHKTA----SAKEQRQLIKSFL-------------LS 1172
O14116       1116 DFIRLACIILSYSQGITDSAFQLLASIPALANQEnlVPAFFNKFREAS----TLKIQKALLTRLL--------------- 1176 Schizosacchar...
P52918       1102 EALYAFTVIFLTLCKEYPSARAFLFEISNGYN----IDELYRNLRSVD----EYKTQRALMIDFIdwvkstsgkedgnVD 1173 Saccharomyces...
Q9HAV4       1092 SLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDS--LDQFDCKLLNPSlqkvADKRRKDQFKRLI-------------AG 1156 human
XP_002272927 1098 DLVGLCREIFVYLSDRDPSPRQVLLSLPCITPYD--LLAFEEALAKTS----SPKEQKQHMKSLL-------------LL 1158
3A6P_A       1157 CIG---KPLGEQF 1166 human
Q54PQ8       1094 VIGiplNKLKKES 1106 Dictyostelium discoideum
KMZ72157     1159 ATEnkfRALVSQR 1171
XP_024534315 1053 AGGdklKALKPQK 1065
XP_024381270 1173 AGGdqlKAFIPQK 1185
O14116       1177 -NSgriVPRTDRR 1188 Schizosaccharomyces pombe 972h-
P52918       1174 HAGderKRQEKRE 1186 Saccharomyces cerevisiae S288C
Q9HAV4       1157 CIG---KPLGEQF 1166 human
XP_002272927 1159 ATGnklKALAAQK 1171
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