Conserved Protein Domain Family
Response_reg_2

?
pfam19192: Response_reg_2 
Response receiver domain
This is a receiver domain (REC) commonly found in the same gene-neighbourhood of its cognate HK. Together they comprise a Two-Component System (TCS). There is a high degree of specificity among REC and DHp domains in a cognate pair. This domain is related to the Response_reg (pfam00072) domain. We found that pfam19191 and this domain show high degree of linkage in the same gene-neighbourhoods across several bacterial lineages. This implies that they comprise a TCS.
Statistics
?
PSSM-Id: 497839
Aligned: 37 rows
Threshold Bit Score: 95.1887
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WP_124327096  22 YIRSVLFVDDDWPEDNPqkkvSDSTREFSESLQSddsvsaydsETItdesdliddeasedidaasseqdkfpdmPSAAAN 101 Desulfonema ish...
WP_127733945  17 PIRSVLIVDDDYPTFEEm---LSDGESLGKDWRN----------------------------------------QTDRVR 53  Methylobacteriu...
WP_046553438  15 PLRSVLIVDDQYPTWEEi---LNSHLDDDAKDADdytrshkklWRT----------------------------KAQGPF 63  Arsukibacterium...
WP_105864015  21 AIRTAVLIDDQFPDYLQi---GTEDVGAFK--------------------------------------------ETARAK 53  Labrys okinawensis
1_pfamImport   1 AIRSVVMIDDDFLTYSEsiraLNNEVDLDYNKID----------------------------------------SSKRAA 40 
WP_099705496  18 AIRSVVMIDDDFITYSDsikaLNREIELDPAKID----------------------------------------SSKRAA 57  unclassified Er...
WP_100211192  14 SIKSAIFIDEKALEPYKa---KPKDPYP----------------------------------------------EVDLSI 44  Tenacibaculum m...
WP_006843704  17 SIKSAIFIDDMIPGLFSs---EED--------------------------------------------------KEAICQ 43  Dysgonomonas mo...
WP_123614591  14 SISNAICIDDEFCAPYDt---EGR--------------------------------------------------NLDAPK 40  Bacteroides aci...
WP_055279200  14 SIKSAVCIDDQYAEPYQk---APK--------------------------------------------------NGKDAE 40  Bacteroides fin...
WP_124327096 102 SQLLGFKESVTGEGI-IFQGiayrKSHHEK-I--IVDLASRADIVVFDWELvWKDK----GRETLSILQELVNKgGLRFI 173 Desulfonema ish...
WP_127733945  54 KIIRGFRARNLLVDIhd-----grNVGLDD-EirEAEHLHQSDLLVLDYQL-DKTRag-dGSIAINIIRKLMANtHFNLV 125 Methylobacteriu...
WP_046553438  64 QVIKKFRERKPGFVIdIHDAvvnaSPEGET-PsqLANHLHQSDLLVLDYNL-EGADsglrGKKAREILYSVLSNqHFNLI 141 Arsukibacterium...
WP_105864015  54 SIYQFIHRRGLICDVln-----wrEVGEARl--eLIDKVRKSDLIVLDYKL-DGDN----PEPALQILRRLANTdHFNMV 121 Labrys okinawensis
1_pfamImport  41 TLESFFQSKNMICDV-----------DNGS-VnfDVDRIRKSDLIIVDYHL-DNNA----PDKTLKLLQDLKDSdHLNMI 103
WP_099705496  58 TLEGYFQSKNMICDI-----------DNGS-VnfDVDRIRKSDLVIMDYHL-DNNA----PDKTISILKELKSSdHLNMI 120 unclassified Er...
WP_100211192  45 NLLKKFKEKGISLAVhk-----ftPNDLQN-EerLKYFFKRRDLVLLDWRL-EGNDg---EEHSLNLLSKIVKEkHIHFC 114 Tenacibaculum m...
WP_006843704  44 PMYESFQANQ--CSLdFFKFtkdwATKSKL-------IFERKDLVVLDWEL-ENEVp--kYRSTLEIIDGAVRTdNLHFV 111 Dysgonomonas mo...
WP_123614591  41 SMRDSFRNQH-QCNLei-----yrYTNFGDiKtlLPVLFKNRDLLILDWEL-NPSEqi-kYQDTLKIIEAGVDSkTLRYI 112 Bacteroides aci...
WP_055279200  41 ILYHSFRQQG-KCDLdi-----ynYNNLEDfIkaREYLFCNKELLILDWEL-SPSAqn-vYEDSLKILEDAINNsYIQFI 112 Bacteroides fin...
WP_124327096 174 CIFTNKQRVHE-IKERIKERLSDek-pdSSEDVDKANSDGEIKPGPSEAVGKADTEKGE 230 Desulfonema ishimotonii
WP_127733945 126 VVHTSE-NLDA-VFQNVILALLP-----YELYELTQDDLFLVDEALEELRSRIGDLDSR 177 Methylobacterium oryzihabitans
WP_046553438 142 IVHTGEDDLEE-VAQECVISLMTsctskFAVQEVQNIASLDEAITDLEDDESFNRATLR 199 Arsukibacterium sp. MJ3
WP_105864015 122 VLYTADVTAP--VAVAVAAAMRG-------VSPPDQRAMLKPAEEEAAHDFLEDPVNAE 171 Labrys okinawensis
1_pfamImport 104 VIYTRE-NLET-VWMQISSTLKGal-diNSLIIDYDNEDVQSYWEDVVLPNLNDNGNKA 159
WP_099705496 121 VIYTRE-ELET-VWMQIASSLKGtv-kiNDRIVDTNNDDLIDYWENTILPDLAQIGDRS 176 unclassified Erwinia
WP_100211192 115 SIFTSELNMNE-IIDNVSTYFSGyn-lgYYQNIIDELDIYRDDNLATFNQISFNDEKAN 171 Tenacibaculum maritimum
WP_006843704 112 CIYSLTPNATQeIHYKILAYYCGnektkAIADITSFKEYVENELGENTDDILPRLKDLL 170 Dysgonomonas mossii
WP_123614591 113 VIYTQNTDTEN-ICKVILRAFSKyr-qdFSDIEKNILENLDEFCAENELDFDGDKVWSL 169 Bacteroides acidifaciens
WP_055279200 113 TIYTQAPSFNE-IVYRIFSYFYFns-meNNSLRKEKYKNLTEEIEDALSEINSDLSSDD 169 Bacteroides finegoldii
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap