Conserved Protein Domain Family
HEF_HK
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pfam19191: HEF_HK 
HEF_HK domain
This is a dimerization and histidine phosphotransfer (DHp) domain found in Histidine Kinases (HK). This domain is belongs to the His_Kinase_A (CL0025) clan. HK domain architectures typically contain DHp domains adjacent to GHKL domains, such as HATPase_c (pfam02518) and HATPase_c_3 (pfam13589) which comprise the ATP-binding regions.
Links
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Statistics
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PSSM-Id: 497838
Aligned: 28 rows
Threshold Bit Score: 84.5694
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_021760692 766 QLGMAIEVINHEFDANIRAIRANVRRLKSWADVNPDLQDLYAGIRNSFEHLDGYLTLFTPLHRRLYR 832  Megalodesulfovibrio gigas
WP_166404823 757 QLGLSVEIIDHELNRLYQGIKAGLQRLKQMVRRAPNARKTVEDIGVNFQHLEQKYQLMSPLYRGTYR 823  Desulfonema ishimotonii
WP_073222037 749 QLGIAVEIIDHEFNQLYAKINNQLGVLGNNEVVNSIKEFRF--LEKNFKQLEDKYALLSPLYRISGA 813  Aequorivita viscosa
WP_091867906 752 QLGVAVEIIDHEFNQLYAKINGSLEKLTNGNLFADEEQFQF--LTQNFKQLENKYELLSPLYRVAGV 816  Pricia antarctica
Q26DQ0       753 QLGVAVEIIDHEFNQLYAKINSSIDKLSEVNLFTDVEQFNF--LKQNFKQLEDKYDLLSPLYRISGV 817  Flavobacteria bacterium BBFL7
WP_006843705 760 QMGIAVEIIDHQFNALYSQVAYAITQINDHLPTDEKAQRNYLSLKTAFEHLEDKYKLMSPLYRTTGK 826  Dysgonomonas mossii
1_pfamImport   1 QLGISVEIIDHEFNVLYAKMAQSVNFLRDYAGEHPEIQDICSQLQISFQHMEANYKMLKPLYRTTRR 67  
ROS87497     171 QLGISAEIIDHELYSLHAQMANSLNYFKEYSRIHTETASQYKQLSVAFEHMEANYKMLQPLYRTAKK 237 
WP_055279199 743 QLGISVEINDHEFHVLYSQMANSINFLKEYAYNHTEIKDQFLQFQTAFQHMETNYKMLQPLYRTTRR 809  Bacteroides
WP_066725522 776 QMGMGVGILQHEFEKSARNMRLAVRDLKPWADGTPELKKVYTRLRNSFDHLDGYLKMLDPLGRRIRR 842  Desulfuromonas sp. DDH964
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