8JBE,7Q3D


Conserved Protein Domain Family
Intu_longin_1
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pfam19031: Intu_longin_1 (This model is not part of the current CDD release)
First Longin domain of INTU, CCZ1 and HPS4
This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.
Links
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Statistics
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PSSM-Id: 523522
Aligned: 38 rows
Threshold Bit Score: 78.4323
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8JBE_B        12 LRSFYIFNSTFGQVE-GEEHKKVLFYHPNDIELNTKIKDVGLSEAIIRFTGTF--Tse-dDCQALHTQKTTQLFYQPEPG 87  Drosophila
XP_018331064 248 ELVGVLFLKTEGLKEdSPEFEEVLYNFPMPYNKNILCTSRGAFLTLNHLINEMvsSkphvSSINYKNQLAHVIYVSCGSK 327
XP_001688618 245 LIFSMIFISKE-YTQ--NDELDVKFCYP-TRENNYLFNSRGSFVTLHSIFNQSfnQqsimTNLKIKNVLYYTTYTVLEDG 320
Q9VPH0       272 MPFAMLLLPPECYQH--EQQQDSLYYFP-EIPDNFLFKARGSFLTLHAVLSEl-hTqplsSRLLVDQVQYHVNYRQLNGF 347 fruit fly
XP_001957259 273 QPFAMLLLPPECYQH--EQQQDSLYYYP-ESPDNFLFKARGSFLTLHAVLSEl-hTqplsSRLLVEQIPYHVNYRRLNGF 348
XP_006007267   5 CNYFFLYDNSKVKEEgDPTRAGICYFYPIQTVLDQQELLCGQIAGVVRCVADIssA----PPSLIKLRRLKFAIKVDGDY 80 
Q9NQG7        15 WNYFFLYDGSKVKEEgDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDIsdS----PPTLVRLRKLKFAIKVDGDY 90  human
Q99KG7        15 WNYFFLYDGSKVKGEgDPTRAGICYFYPPQTLLDQQELLCGQLAGVVRCLWDLsgT----PPMLIRMRNLKFAIRADGDY 90  house mouse
3_pfamImport   1 WNYFFLYDGSKVKEEgDPTRAGICYFYPSQTVLDQQELLCGQIAGVVHCITEIssA----PPSLIQLRKLKFAVRVDGEY 76 
1_pfamImport   1 MMIVFVYDTQCCTAEeDDPINAVLYFHPGWVSDTQRHALAGQVVGAAHCVKTLl-----sPPVSITLQSGKFIIREYGRY 75 

8JBE_B        88 YWLVLVLNVPkevrlkegvevadyrgaeISDRIYRAILRQCYQMFRFQNG 137 Drosophila
XP_018331064 328 LLLFMFPDKC------------------LSVEGSQLVAEEIFRTIEFMYQ 359
XP_001688618 321 ILLLGFSSKY------------------SSVFAVKQKSEQICRFLNALYR 352
Q9VPH0       348 LVLFAYAGGL------------------CCAAECSLRSDELIGYIRFSLP 379 fruit fly
XP_001957259 349 LVLFAYAGGL------------------CSAAECSLRSDELIDYIRFSLP 380
XP_006007267  81 LWALGCAVE-------------------IPDVSCMQFLGQLIQLFKFYNG 111
Q9NQG7        91 LWVLGCAVE-------------------LPDVSCKRFLDQLVGFFNFYNG 121 human
Q99KG7        91 LWALGCGVE-------------------ISDASCRQFLDQLIGFFHFYMG 121 house mouse
3_pfamImport  77 LWALGCTIE-------------------LPDISCQQFLELLIGLFRFYNG 107
1_pfamImport  76 VLAIGSDRN-------------------IPDWVLKNRANLLTSMIKVYHG 106
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