Conserved Protein Domain Family
Wheel

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pfam18972: Wheel 
Cns1/TTC4 Wheel domain
The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.
Statistics
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PSSM-Id: 497684
Aligned: 24 rows
Threshold Bit Score: 143.142
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021870425 231 DPEALppapplhvsgssassgsheiwlpppiDTTLIYPVFLLYPSHSQSDFITHFSEETSLSDHLNVMFPsvsptsnspa 310
XP_007872559 251 SPLDI--------------------------TSTLLFPVTFLYPLVLQSDFITQVAETSTIQEQLDLVLA---------- 294
XP_002840004 274 DPLDP--------------------------TSELYFPAIFLYPLQGQSDFVKAFPVSSKVGMQLGIVLA---------- 317
EPS40598     253 DPLDP--------------------------ESTLYFPLLILYPLHLESDFVKSISEDETVHSQLQEILSpfd------- 299
O13754       236 TFDDP--------------------------KSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVFQ---------- 279 Schizosaccharom...
XP_002173149 241 VPEDA--------------------------SSELFFPTILLYPLESQSDFVPALSEHSTAQDLLNTVFE---------- 284
Q6C275       283 DPLDP--------------------------TSTLLVPVLLLYPCDLQSDFLAEVDIGSTPGQALNTVFE---------- 326 Yarrowia lipoly...
ODQ63948     252 NETDP--------------------------SSTIYFPAVFLYPVDYQSDFIQEFALEHSVQDHLEAVFE---------- 295
XP_020046585 274 DFKDI--------------------------QSQLIFPVIVIHPIENKFDFVQAFGELSNASDLLKLLYN---------- 317
XP_002491377 258 AETDV--------------------------ESQMIFPGMVLYPTLDEWDFVEQISELNTPKEIIGMLMD---------- 301
XP_021870425 311 SP-EW----DTKREYVT--ENLVVYVETAQKR------LLKAGKDLTLREVIKKavkesadgsgkpdGMVMRDGLLSFVV 377
XP_007872559 295 SKpQW----DKNNEYSP--SNVEVCIETKIGE------IIKVKKNAQLLDVLAN-------------KVEVLDGIVRLLI 349
XP_002840004 318 KFpEW----DHEKAYSPp-GKVEVFVETRTGG------LVRVGKKAALGSVLGNg-----------gKVEVVDGLVKFLV 375
EPS40598     300 -lpNW----DHEKEYAY--KNVDVLVEKGKYGihenptLSKVGRNIPLKKILQGg------------KMELIDGILRVFV 360
O13754       280 SPaPW----DVHQLYNP--DSLDVFATTDTLG------LIKVGKNVPILKALTHp------------KVTLIDGLVQLHV 335 Schizosaccharom...
XP_002173149 285 TPaEW----DTSAEYRP--NVVDAFIQTSTGG------LVKVGKRVPILKVLQHp------------KVVVMDGIIQLIV 340
Q6C275       327 HPpMWfs-gDHVAQYDV--KNLEVFVQTESGG------LVKIGKKVSFESVLSApk----------pKVPLIDNVITLHC 387 Yarrowia lipoly...
ODQ63948     296 ETpEWfgniDNPTDYNI--KNLEAYLQTESGG------LIKAGKKLPISSVLSNek----------lKVPVVDNVIRVYI 357
XP_020046585 318 ---------DDNERYFNniKRKQIFLETDKGG------LIKLGKNVEISQVLQQqe----------pKIPLFDKCLRVYI 372
XP_002491377 302 RPpEYfa-qPGHGNFQP--KNLQAYMQTQGGG------LVKVGKNLSFKEILSSkq----------pIIPLMDNSLRIYV 362
XP_021870425 378 LVKGDQeKQWIDQF 391
XP_007872559 350 LPKNKI-DLWINEW 362
XP_002840004 376 VPKGEV-GAFLEDW 388
EPS40598     361 IPKGRL-TEFLDDW 373
O13754       336 VPHHLA-SDWISSW 348 Schizosaccharomyces pombe 972h-
XP_002173149 341 VPKNKT-AEWLATR 353
Q6C275       388 VPKEKR-EQWLKTW 400 Yarrowia lipolytica
ODQ63948     358 LPKNKS-AEWIKSW 370
XP_020046585 373 VDKSDI-SSWIKQW 385
XP_002491377 363 VPKQDG--DFLSQW 374
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