4FGV


Conserved Protein Domain Family
CRM1_repeat_2

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pfam18784: CRM1_repeat_2 (This model is not part of the current CDD release)
CRM1 / Exportin repeat 2
Chromosome region maintenance 1 / Exportin 1 mediates the nuclear transport of proteins bearing a leucin-rich nuclear export signal (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-, C-terminal and central repeats show slightly different structural arrangements, with N- and C- terminal repeats interacting with each other. This Pfam entry includes some CRM1 repeats that fail to be detected with the pfam18777 model.
Statistics
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PSSM-Id: 523446
Aligned: 68 rows
Threshold Bit Score: 59.0371
Created: 20-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FGV_A        411 RKHKYKEVLSNLRVVMIEKMVRPEEVLIVENDEGEIVREFVKDTDSVQLYKTIRECLVYLTHLDVVDM 478  Thermochaetoides thermoph...
XP_004039825  396 EKNVYPLILTQVRTIIVSRMAKPQEVLIVIDENGNPCKEELQDTENNSLYELLKELLINLAKLDWQDM 463 
Q22RP0        478 QKTIYPKIMTQVRTIIISRMAKPQEVLIVI-EEGVPVKEELVDTENNSLYDLLKEILINLSKLDWSDM 544  Tetrahymena thermophila S...
XP_001645797  405 KLNEYSRLYSDLRLTIVDRMVRPEEVLILKNDEGEISKQYVQDTENEQLFKIERDVLIYLSRFDIVET 472 
XP_028882449  384 LHKKLTTTLSNVRFVLIKRMAKPEEVIIVE-EEGELRRERMTDVEELQLYNLMREALVFLTNLDPHDT 450 
Q382A3        384 LHRKLALVLSNVRFTLIKKMARPEEVIIVV-EDGEVRRVHMKDVEELQLYKLMRETLVFLTYLDPQDM 450  Trypanosoma brucei
XP_001329729  364 FKQIYNEVLPHVSRLLMQKMPRPPEVLIVVDSMGGITRDTQKETLEASLFQVVRQNLVIISHIDIEDT 431 
EPR79648      379 FRQNFSDILKTLAKILTEKMVRPQEVFIVENEFGEIVKEKMVETEQIEFYKKMKKTIFYVAFLQPDFI 446 
Q8SU86        429 RRSNYIGVLNQLMGTLVDKMPRPEEVFIVVDEYNEVIRKKMTDTDQIEFYRKMRGCLYHLAFLIEDDM 496  Encephalitozoon cuniculi
XP_024331448  394 RRFEYKGVLVQLLNCLVEKMPRPEEVFIIVNEYGEIIKNKLIETDQIDFYKKMKSCLYHLAFLIEDDL 461 
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